A Novel Approach to Characterize the Speciation and Toxicity of Metals in Atmospheric Particulate Matter
表征大气颗粒物中金属形态和毒性的新方法
基本信息
- 批准号:1802474
- 负责人:
- 金额:$ 33.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Airborne particles, or particulate matter (PM), impart numerous detrimental effects on human health. Metals are present at trace levels in PM, but these metals are hypothesized to have enhanced toxicity to humans compared to other constituents that are present in particles at much greater levels. Metals in PM take different chemical forms, and metal toxicity through other routes of exposure is affected by these different chemical forms. The aims of this work are (i) to develop a new method to determine the chemical forms of important metals in PM, and (ii) to link the different metal species to PM toxicity. This work will contribute to the training and education of undergraduate and graduate students in chemical and environmental engineering. If successful, this project will provide new insights on how to identify and quantify toxic metal exposure from PM matter in different environments. PM is a ubiquitous component of the atmosphere and influences climate and human health. PM is comprised of a diverse array of chemical species that reflect the numerous sources and processes that contribute to PM levels. Although metals typically constitute a small fraction of PM mass, epidemiological and toxicological studies have associated metals with a number of human health effects. This suggests that some metals have an enhanced toxicity compared to other chemical species found in PM. Previous studies linked metals with the generation of reactive oxygen species (ROS), providing a likely explanation for their role in adversely affecting health. Despite the evidence from epidemiological and toxicological studies, a clear understanding of the toxicity of specific PM metals is currently lacking. This limitation is due in part to a lack current measurement methods that can simultaneously characterize the oxidation state and speciation of the full suite of metals present in PM. These metals can exist in multiple oxidation states and chemical forms, and the toxicity of metals in PM is likely related to these characteristics. The aim of this proposal is to develop a new approach to simultaneously determine the oxidation state and chemical speciation for a suite of PM metals that are linked with enhanced toxicity: V, Ni, Zn, Cu, Fe, Cr, and Mn. This approach will use a combination of direct measurements and thermodynamic equilibrium modeling to determine the speciation of metals in PM. The metal speciation will be combined with ROS activity measurements to provide unprecedented insight into the chemical species in PM most likely to induce oxidative stress. Once this approach is validated in the laboratory, it will be applied to characterize the toxicity of PM metals in an urban environment. Metal speciation is strongly affected by both the pH and oxidation-reduction potential (ORP). This study will significantly advance understanding of metal speciation in PM because it will directly account for the pH and ORP in atmospheric particles. This represents the first study to link metal speciation in PM with these two controlling variables. The new approach will ultimately be developed for widespread application to future studies, including potential applications to archived PM data sets. This also represents the first study to link ROS activity with simultaneous determinations of metal oxidation state and speciation in PM. This research will provide significant insight into the sources and processes that influence PM toxicity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
空气中的颗粒物或颗粒物质(PM)对人类健康造成许多不利影响。 金属在PM中以痕量水平存在,但与颗粒中以更高水平存在的其他成分相比,这些金属被假设对人类具有增强的毒性。 PM中的金属有不同的化学形式,通过其他接触途径的金属毒性受到这些不同化学形式的影响。这项工作的目的是(i)开发一种新的方法来确定PM中重要金属的化学形式,以及(ii)将不同的金属物种与PM毒性联系起来。 这项工作将有助于培养和教育本科生和研究生在化学和环境工程。如果成功,该项目将为如何识别和量化不同环境中PM物质的有毒金属暴露提供新的见解。PM是大气中普遍存在的成分,影响着气候和人类健康。PM由多种化学物质组成,反映了导致PM水平的众多来源和过程。虽然金属通常只占PM质量的一小部分,但流行病学和毒理学研究已将金属与许多人类健康影响联系起来。这表明,与PM中发现的其他化学物质相比,某些金属具有增强的毒性。以前的研究将金属与活性氧(ROS)的产生联系起来,为它们对健康的不利影响提供了可能的解释。尽管有流行病学和毒理学研究的证据,但目前对特定PM金属的毒性缺乏明确的认识。这种限制部分是由于缺乏当前的测量方法,可以同时表征氧化态和形态的全套金属中存在的PM。这些金属可以以多种氧化态和化学形式存在,PM中金属的毒性可能与这些特性有关。该提案的目的是开发一种新的方法来同时确定与增强毒性相关的一组PM金属的氧化态和化学形态:V,Ni,Zn,Cu,Fe,Cr和Mn。这种方法将使用直接测量和热力学平衡模型相结合,以确定PM中金属的形态。金属形态将与ROS活性测量相结合,以提供对PM中最有可能诱导氧化应激的化学物质的前所未有的洞察。 一旦这种方法在实验室中得到验证,它将被应用于表征城市环境中PM金属的毒性。 金属形态受pH和氧化还原电位(ORP)的强烈影响。这项研究将大大推进对PM中金属形态的理解,因为它将直接解释大气颗粒物中的pH值和ORP。这是第一个研究链接PM中的金属形态与这两个控制变量。新方法最终将被开发用于未来研究的广泛应用,包括存档PM数据集的潜在应用。这也代表了第一个研究链接ROS活性与同时测定金属氧化态和形态的PM。这项研究将为影响PM毒性的来源和过程提供重要的见解。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Precipitation of aqueous transition metals in particulate matter during the dithiothreitol (DTT) oxidative potential assay
二硫苏糖醇 (DTT) 氧化电位测定过程中颗粒物中水性过渡金属的沉淀
- DOI:10.1039/d2em00005a
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Yalamanchili, Jayashree;Hennigan, Christopher J.;Reed, Brian E.
- 通讯作者:Reed, Brian E.
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Christopher Hennigan其他文献
Christopher Hennigan的其他文献
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{{ truncateString('Christopher Hennigan', 18)}}的其他基金
Collaborative Research: Ionic Solutions and the Partitioning of Oxygenated Organic Compounds in the Troposphere
合作研究:离子溶液和含氧有机化合物在对流层中的分配
- 批准号:
2024178 - 财政年份:2020
- 资助金额:
$ 33.66万 - 项目类别:
Standard Grant
Collaborative Research: Effects of Ammonia on the Chemical and Physical Properties of Atmospheric Secondary Organic Aerosol
合作研究:氨对大气二次有机气溶胶化学和物理性质的影响
- 批准号:
1719252 - 财政年份:2017
- 资助金额:
$ 33.66万 - 项目类别:
Standard Grant
CAREER: Characterizing Acid-Catalyzed Secondary Organic Aerosol Formation in the Atmosphere
职业:表征大气中酸催化的二次有机气溶胶的形成
- 批准号:
1454763 - 财政年份:2015
- 资助金额:
$ 33.66万 - 项目类别:
Standard Grant
EAGER: Quantifying Reversible and Irreversible Aqueous Secondary Organic Aerosol (SOA) Formation in the Atmosphere
EAGER:量化大气中可逆和不可逆水性二次有机气溶胶 (SOA) 的形成
- 批准号:
1464458 - 财政年份:2014
- 资助金额:
$ 33.66万 - 项目类别:
Standard Grant
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