Collaborative Research: Understanding and manipulating the solvent microenvironment for selective, catalytic amination of renewable oxygenates

合作研究：了解和操纵溶剂微环境，用于可再生含氧化合物的选择性催化胺化

• 批准号: 1805307
• 负责人: Andreas Heyden
• 金额: $ 22.5万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1805307&HistoricalAwards=false
• 关键词: Collaborative; Research; Understanding; manipulating; solvent

The initial steps of biomass refining involve breakdown of the raw material to a biocrude oil containing a mixture of building block chemicals. The building block chemicals can be further refined to higher value products, often in the liquid phase, with the aid of a solvent and a solid catalyst. This project will investigate the transformation of one of those building block chemicals, 3-hydroxybutryolactone (3HBA), to several higher-value chemicals. Theoretical analysis and experimental methods will be combined to understand how the solvent influences the performance of the catalyst in promoting conversion of 3HBA to the desired products. Results of the study can be applied more generally to other bio-based chemicals to support a growing bio-refining industry relevant for the transition to renewable chemical production. The project will contribute to a highly trained workforce of experts in biomass processing, while also adding to U.S. technical prominence in biomanufacturing of chemicals. A major goal of heterogeneous catalysis research is to identify active sites and to understand how they interact with reactants, products, and the bulk environment to facilitate chemical transformations. While most catalyst studies focus on catalyst discovery, it is often the bulk reaction environment that benefits most from redesign. The focus on solvation effects in heterogeneous catalysis has recently expanded with the trend toward liquid-phase, catalytic processing of biomass. Motivated by this shift, the project focuses on developing the scientific foundations needed for the rational design of solvent systems for catalytically processing renewable oxygenates. Specifically, the proposed research aims at understanding how the nature of the solvent microenvironment impacts activity and selectivity of ruthenium (Ru) catalysts during reductive amination of 3-HBA to form 2-amino-3-hydroxytetrahydrofuran and 3-aminotetrahydrofuran. The proposed combination of computational and experimental research is structured around (1) state-of-the-art density functional theory calculations, (2) machine learning tools for accelerating complex reaction network investigation, (3) microkinetic reactor modeling under various experimental reaction conditions, (4) vapor phase catalyst evaluation and kinetic isotope effect studies, (5) catalyst evaluations in condensed phases of water, ethanol, 1,4-dioxane, and cyclohexane, and (6) systematic correlation of experimental data with computational models through Bayesian statistical analysis. An iterative research loop is proposed, with experimental observations leading to hypotheses that motivate new computations, while computational models will rationalize experimental findings and guide new investigations. The research program includes undergraduate outreach, and research results will be integrated into undergraduate and graduate electives and the core chemical engineering curriculum at both Syracuse University and the University of South Carolina.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物质精炼的初始步骤包括将原材料分解为含有化学成分混合物的生物原油。 借助溶剂和固体催化剂，结构单元化学品可以进一步精炼成更高价值的产品，通常是在液相中。 该项目将研究将其中一种基础化学品 3-羟基丁内酯 (3HBA) 转化为几种更高价值的化学品。 将理论分析和实验方法相结合，以了解溶剂如何影响催化剂促进3HBA转化为所需产物的性能。 该研究的结果可以更广泛地应用于其他生物基化学品，以支持与向可再生化学品生产过渡相关的不断增长的生物精炼行业。 该项目将有助于培养训练有素的生物质加工专家队伍，同时也增强美国在化学品生物制造方面的技术优势。 多相催化研究的一个主要目标是识别活性位点并了解它们如何与反应物、产物和整体环境相互作用以促进化学转化。 虽然大多数催化剂研究都集中在催化剂发现上，但从重新设计中受益最多的往往是本体反应环境。近年来，随着生物质液相催化加工的趋势，对多相催化中溶剂化效应的关注不断扩大。受这一转变的推动，该项目重点开发合理设计催化加工可再生含氧化合物的溶剂系统所需的科学基础。具体来说，该研究旨在了解溶剂微环境的性质如何影响 3-HBA 还原胺化形成 2-氨基-3-羟基四氢呋喃和 3-氨基四氢呋喃过程中钌 (Ru) 催化剂的活性和选择性。拟议的计算和实验研究组合围绕（1）最先进的密度泛函理论计算，（2）用于加速复杂反应网络研究的机器学习工具，（3）各种实验反应条件下的微动力学反应器建模，（4）气相催化剂评估和动力学同位素效应研究，（5）水、乙醇的凝聚相催化剂评估， 1,4-二恶烷和环己烷，以及（6）通过贝叶斯统计分析将实验数据与计算模型系统相关。提出了一个迭代研究循环，通过实验观察得出激发新计算的假设，而计算模型将使实验结果合理化并指导新的研究。该研究计划包括本科生推广，研究成果将纳入雪城大学和南卡罗来纳大学的本科生和研究生选修课以及核心化学工程课程中。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Analysis of thermodynamics, kinetics, and reaction pathways in the amination of secondary alcohols over Ru/SiO2

• DOI: 10.1016/j.jcat.2023.05.003
• 发表时间: 2023-05
• 期刊: Journal of Catalysis
• 影响因子: 7.3
• 作者: Xin Gao;Dia Sahsah;Andreas Heyden;Jesse Q. Bond

Dilute Limit Alloy Pd–Cu Bimetallic Catalysts Prepared by Simultaneous Strong Electrostatic Adsorption: A Combined Infrared Spectroscopic and Density Functional Theory Investigation

• DOI: 10.1021/acs.jpcc.2c00234
• 发表时间: 2022-07
• 期刊: The Journal of Physical Chemistry C
• 作者: Leandro T. De Castro;Dia Sahsah;Andreas Heyden;J. Regalbuto;C. Williams

Leveraging De Donder relations for a thermodynamically rigorous analysis of reaction kinetics in liquid media

利用 De Donder 关系对液体介质中的反应动力学进行热力学严格分析

• DOI: 10.1016/j.jcat.2021.09.026
• 发表时间: 2021
• 期刊: Journal of Catalysis
• 影响因子: 7.3
• 作者: Schwartz, Thomas J.;Bond, Jesse Q.
• 通讯作者: Bond, Jesse Q.