Photoredox Polymerization of O-Carboxyanhydrides for Functionalized Polyesters

O-羧酸酐光氧化还原聚合制备功能化聚酯

• 批准号: 1807911
• 负责人: Rong Tong
• 金额: $ 43万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1807911&HistoricalAwards=false
• 关键词: Photoredox; Polymerization; Carboxyanhydrides; Functionalized; Polyesters

Polyesters are important biocompatible polymers that can degrade in human bodies. They are widely used in everyday applications ranging from clothing and packaging to agriculture and biomedicine. However, the small number of structurally-different polyesters limit the range of materials properties and utility in applications that demand mechanical strength. To address this challenge, the research group of Professor Rong Tong at the Virginia Polytechnic Institute and State University explores new synthetic strategies to produce polyesters from natural amino acids, that have a wider range of chemical structures and properties. This research develops new reactions for preparing environmentally-friendly and biodegradable polyesters that can serve as alternatives to petroleum-based plastics in commercial applications. The multidisciplinary research project is integrated with educational and outreach activities for undergraduates and students of underrepresented groups. An outreach program that emphasizes hands-on demonstrations of biodegradable polyesters is developed for middle and high school students in Montgomery County, Virginia.With the support from the Macromolecular, Supramolecular and Nanochemistry Program of the Division of Chemistry, Professor Tong's group develops novel controlled polymerization chemistry to synthesize functionalized biodegradable polyesters from O-carboxyanhydries - an alternative class of highly active monomers with a rich variety of side-chain functionalities. Specifically, this research identifies photoredox catalytic systems that enable efficient synthesis of functionalized polyesters at room-temperature using light. Such polymers cannot be achieved using conventional methods. Using newly developed catalysts, stereoregular polyesters that possess improved thermal and mechanical properties compared with atactic homopolymers are synthesized. Additional research activities include the study of the photoredox ring-opening polymerization mechanisms and the exploration of one-pot, sequence-controlled, photoredox copolymerization of two monomers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

聚酯是重要的生物相容性聚合物，可在人体内降解。它们广泛应用于日常应用，从服装和包装到农业和生物医学。 然而，少量结构不同的聚酯限制了材料性质的范围和在需要机械强度的应用中的实用性。 为了应对这一挑战，弗吉尼亚理工学院和州立大学的Rong Tong教授的研究小组探索了新的合成策略，从天然氨基酸中生产具有更广泛化学结构和性质的聚酯。 这项研究开发了用于制备环境友好和可生物降解聚酯的新反应，这些聚酯可以在商业应用中作为石油基塑料的替代品。多学科研究项目与针对本科生和代表性不足群体的学生的教育和外联活动相结合。在弗吉尼亚州蒙哥马利县为中学生开发了一个推广计划，强调可生物降解聚酯的动手示范。在化学系大分子，超分子和纳米化学计划的支持下，Tong教授的研究小组开发了新型可控聚合化学，从O-羧基氰基化合物合成功能化的可生物降解聚酯，具有丰富的侧链官能团的高活性单体的替代类别。具体来说，这项研究确定了光氧化还原催化系统，使功能化聚酯在室温下使用光的有效合成。 这样的聚合物不能使用常规方法获得。使用新开发的催化剂，具有改善的热性能和机械性能相比，无规立构均聚物的有规立构聚酯的合成。其他研究活动包括光氧化还原开环聚合机理的研究和探索一锅法、顺序控制、两种单体的光氧化还原共聚。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Recent Advances in Sequence‐Controlled Ring‐Opening Copolymerizations of Monomer Mixtures

单体混合物的序列控制环开共聚的最新进展

• DOI: 10.1002/asia.202201147
• 发表时间: 2023
• 期刊: Chemistry – An Asian Journal
• 作者: Wang, Xiaoqian;Huo, Ziyu;Xie, Xiaoyu;Shanaiah, Narasimhamurthy;Tong, Rong
• 通讯作者: Tong, Rong

Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement.

• DOI: 10.1038/s41467-021-25391-z
• 发表时间: 2021-08-26
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Chin AL;Jiang S;Jang E;Niu L;Li L;Jia X;Tong R
• 通讯作者: Tong R

Living Ring-Opening Polymerization of O-Carboxyanhydrides: The Search for Catalysts

• DOI: 10.3389/fchem.2018.00641
• 发表时间: 2018-12
• 期刊: Frontiers in Chemistry
• 影响因子: 5.5
• 作者: Yongliang Zhong;R. Tong

Functionalized Polyesters via Stereoselective Electrochemical Ring-Opening Polymerization of O -Carboxyanhydrides

通过 O-羧酸酐的立体选择性电化学开环聚合制备功能化聚酯

• DOI: 10.1021/acsmacrolett.0c00364
• 发表时间: 2020
• 期刊: ACS Macro Letters
• 影响因子: 7.015
• 作者: Zhong, Yongliang;Feng, Quanyou;Wang, Xiaoqian;Chen, Jia;Cai, Wenjun;Tong, Rong
• 通讯作者: Tong, Rong