权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Active Assembly of Conducting Peptide Gels

导电肽凝胶的主动组装

基本信息

批准号：
1808143
负责人：
Rein Ulijn
金额：
$ 48.83万
依托单位：
Research Foundation CUNY - Advanced Science Research Center
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2022-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1808143&HistoricalAwards=false
关键词：
Active Assembly Conducting Peptide Gels

项目摘要

In living organisms, some structural components are assembled only when they are demanded for specific functions and then dissembled when they are no longer needed. In this project, the research teams of Prof. Rein Ulijn at the City University of New York, and Prof. Allon Hochbaum at the University of California, Irvine, aim to understand how to control dynamic assembly processes and explore the feasibility of incorporating design concepts from the biological world into synthetic, non-living materials. An important goal of this project is to develop new approaches to preparing electrically conducting assemblies that can change shape and make new connections in response to the environment or external stimuli, mimicking the dynamic behavior of biological materials. The assemblies are potentially useful as materials for interfacing electronic devices with biological systems in biomedical applications. This project provides interdisciplinary research training to graduate and undergraduate students. The team inspires high school students, including underrepresented minority students, from the local area (Harlem, NY and Irvine, CA) with hands-on education and discovery programs.With the support from the Macromolecular, Supramolecular and Nanochemistry Program of the NSF Division of Chemistry, the research team designs transient assemblies of peptide nanostructures, based on biocatalytic reactions that utilize chemical fuels to dynamically sustain the self-assembled state. Activated amino acid methyl esters, with the energy stored in the ester bond, serve as fuels to provide the chemical energy required to drive assembly processes. The amino acid part encodes the self-assembly of nanofibers that entangle to form a gel-phase material. Modification of the peptide sequence enables modulation of the assembly dynamics and fiber stability. Electronic functionality is introduced by incorporating semi-conducting organic molecules into the peptide building blocks. Another aim of the project is to integrate the resulting materials with neuronal cells to investigate whether the behavior of neuronal cell can be influenced by electronic stimulation through these materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在活的有机体中，一些结构组件只有在特定功能需要时才组装，然后在不再需要时拆卸。在这个项目中，纽约城市大学的Rein Ulijn教授和加州大学欧文分校的Allon Hochbaum教授的研究团队旨在了解如何控制动态组装过程，并探索将生物世界的设计概念融入合成非生命材料的可行性。该项目的一个重要目标是开发新的方法来制备导电组件，这些组件可以根据环境或外部刺激改变形状并建立新的连接，模仿生物材料的动态行为。该组装体在生物医学应用中作为电子器件与生物系统的接口材料是潜在有用的。该项目为研究生和本科生提供跨学科的研究培训。该团队激励高中生，包括来自当地的少数民族学生（哈莱姆，纽约和欧文，加利福尼亚州）与动手教育和发现计划。在NSF化学部的大分子，超分子和纳米化学计划的支持下，研究小组设计了肽纳米结构的瞬时组装，基于利用化学燃料动态维持自组装状态的生物催化反应。活化的氨基酸甲酯，与储存在酯键中的能量，作为燃料提供所需的化学能驱动组装过程。氨基酸部分编码纳米纤维的自组装，纳米纤维缠结形成凝胶相材料。肽序列的修饰使得能够调节组装动力学和纤维稳定性。通过将半导体有机分子并入肽构建块中来引入电子功能性。该项目的另一个目的是将所得材料与神经细胞结合，以研究通过这些材料的电子刺激是否会影响神经细胞的行为。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。