Enzyme Responsive Materials for Biology and Medicine
用于生物学和医学的酶响应材料
基本信息
- 批准号:EP/D07410X/2
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Fellowship
- 财政年份:2008
- 资助国家:英国
- 起止时间:2008 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.
本研究的目的是开发新的途径,以合理设计的酶响应材料(ERMs)的生物医学应用。这些材料可以改变性质,例如它们可以响应于生化反应而膨胀/塌陷或从溶液变为凝胶。这些材料可应用于响应疾病特异性酶的药物的控制释放。它们也可以用于触发组装用于细胞生长的基质,并应用于组织工程。该项目的成果将是(i)新的交互式生物材料的开发和全面表征,(ii)增加对分子水凝胶中结构/功能关系的基本理解,(iii)3D细胞培养支架的酶触发组装中的概念验证应用,以及(iv)酶触发药物递送。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)
- DOI:10.1039/c0py00291g
- 发表时间:2011-01-01
- 期刊:
- 影响因子:4.6
- 作者:Caponi, Pier-Francesco;Qiu, Xing-Ping;Ulijn, Rein V.
- 通讯作者:Ulijn, Rein V.
Mechanistic insights into phosphatase triggered self-assembly including enhancement of biocatalytic conversion rate
- DOI:10.1039/c3sm51177d
- 发表时间:2013-09
- 期刊:
- 影响因子:3.4
- 作者:Kate Thornton;Yousef M. Abul-Haija;N. Hodson;R. Ulijn
- 通讯作者:Kate Thornton;Yousef M. Abul-Haija;N. Hodson;R. Ulijn
Enzyme-Activated Surfactants for Dispersion of Carbon Nanotubes
- DOI:10.1002/smll.200801184
- 发表时间:2009-03-06
- 期刊:
- 影响因子:13.3
- 作者:Cousins, Brian G.;Das, Apurba K.;Ulijn, Rein V.
- 通讯作者:Ulijn, Rein V.
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Rein Ulijn其他文献
Rein Ulijn的其他文献
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{{ truncateString('Rein Ulijn', 18)}}的其他基金
I-Corps: Using Peptides for Biomolecules Encapsulation, Storage, and Preservation
I-Corps:使用肽进行生物分子封装、储存和保存
- 批准号:
2414552 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Nanoscience Connected to Life: An Interdisciplinary Traineeship Program in Bioinspired Nanotechnology
纳米科学与生命相连:仿生纳米技术的跨学科培训计划
- 批准号:
2151945 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Standard Grant
Planning IUCRC at City University of New York: Center for Biological Applications of Solid-State Systems (CBASS)
纽约城市大学规划 IUCRC:固态系统生物应用中心 (CBASS)
- 批准号:
1822149 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Standard Grant
Active Assembly of Conducting Peptide Gels
导电肽凝胶的主动组装
- 批准号:
1808143 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: REU Site: Nano-NY
合作研究:REU 地点:Nano-NY
- 批准号:
1659629 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Standard Grant
Protein Stabilising Molecular Gels: Interfacing biological machinery with electronics for biosensing and bioenergy devices
蛋白质稳定分子凝胶:将生物机械与生物传感和生物能源设备的电子设备连接起来
- 批准号:
BB/J021113/1 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Research Grant
Dynamic surfaces to mimic mesenchymal stem cell niche functions
模拟间充质干细胞生态位功能的动态表面
- 批准号:
BB/K007513/1 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Research Grant
A New Tool for Biochemical Analysis: Combining Enzyme-Responsive Gels with LCD Detection
生化分析新工具:酶响应凝胶与 LCD 检测相结合
- 批准号:
BB/G014515/1 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Research Grant
Designed Peptide Gels for 3D Cell Culture
设计用于 3D 细胞培养的肽凝胶
- 批准号:
EP/G005877/1 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Research Grant
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