Meeting: SICB Symposium on Integrative Biology of Sensory Hair Cells San Francisco, CA, January 6, 2018

会议：SICB 感觉毛细胞综合生物学研讨会，加利福尼亚州旧金山，2018 年 1 月 6 日

• 批准号: 1809860
• 负责人: Duane McPherson
• 金额: $ 1.35万
• 依托单位: SUNY College at Geneseo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1809860&HistoricalAwards=false
• 关键词: Meeting; SICB; Symposium; Integrative; Biology

The "Society for Integrative and Comparative Biology (SICB) Symposium on Integrative Biology of Sensory Hair Cells" will take place January 6, 2018 at the San Francisco Marriott Marquis Hotel in San Francisco, California. This meeting will focus on hair cells, which are found in invertebrate aquatic animals, in the grooves in the skin (called the lateral line system) of fish and larval amphibians, and in the inner ear of adult amphibians, reptiles, birds and mammals. These small cells respond to water vibration and sound, and are also vital for orientation relative to gravity, acceleration, and fluid motion detection. In humans, they are necessary for hearing and for vestibular function, and developmental defects or later loss of function in these cells are the major cause of deafness, impairments of postural stability, and of the ability to stand or walk. Despite much recent research progress on hair cell biology in invertebrate animals and in the auditory, vestibular, and lateral line systems of vertebrate animals, hair cell researchers working in those different systems tend not interact with each other, and therefore overlook major new research developments. This meeting is both timely and important, and two expected outcomes are (1) the broad dissemination of new information to biology teaching faculty and their graduate and undergraduate students, all of whom are the main attendees of the SICB conference, and (2) the formation of new scientific collaborations that will lead to novel approaches to the fundamental questions of hair cell evolution, development, physiology, and regeneration.Hair cells are responsible for mechano-transduction, hearing and vestibular function in a variety of invertebrate and vertebrate animals. This symposium brings together researchers who study hair cells in a variety of organ systems (invertebrate outer body, cochlear, vestibular, and lateral line systems) and who utilize a variety of experimental approaches (including molecular developmental analysis, perturbation of gene expression, and electrophysiology, to name a few), with the goal of initiating a major interdisciplinary conversation and exchange of ideas about hair cell function, development and evolution. For example, the discovery of sensory hair cells in ascidian tunicates, a non-vertebrate chordate, has fostered important evolutionary-developmental studies that have illuminated common features with the development hair cells in cranial placodes in vertebrates. In vertebrate animals, cochlear and vestibular hair cells are derived from the otic placode, while hair cells of the lateral line system are derived from lateral line placodes. Molecular analysis of the genes required for hair cell development and differentiation in these different contexts is ongoing, as are efforts to identify the ion channel or channels responsible for mechano-electrical transduction by hair cells in the inner ear. It is thus a highly opportune time to bring researchers from these different communities together with the joint purposes of broadly disseminating new information about hair cells to biology teaching faculty and their graduate and undergraduate students, all of whom are the main attendees of the SICB conference, and fostering new scientific collaborations that will lead to novel approaches to the fundamental questions of hair cell evolution, development, physiology, and regeneration.

“综合与比较生物学学会(SICB)感觉毛细胞综合生物学研讨会”将于2018年1月6日在加利福尼亚州旧金山的旧金山万豪酒店举行。本次会议将关注毛细胞，毛细胞存在于无脊椎动物的水生动物、鱼类和幼体两栖动物皮肤的沟槽(称为侧线系统)以及成年两栖动物、爬行动物、鸟类和哺乳动物的内耳中。这些小细胞对水的振动和声音做出反应，对于相对于重力、加速度和流体运动检测的方向也是至关重要的。在人类中，它们是听力和前庭功能所必需的，这些细胞的发育缺陷或后来功能丧失是耳聋、姿势稳定性和站立或行走能力受损的主要原因。尽管最近在无脊椎动物和脊椎动物的听觉、前庭和侧线系统中的毛细胞生物学研究取得了很大进展，但在这些不同系统中工作的毛细胞研究人员往往不会相互作用，因此忽视了重大的新研究进展。这次会议既及时又重要，预期的两个结果是：(1)向生物学教师及其研究生和本科生广泛传播新信息，他们都是SICB会议的主要与会者；(2)形成新的科学合作，将导致对毛细胞进化、发育、生理和再生等基本问题的新方法。毛细胞负责各种无脊椎动物和脊椎动物的机械传导、听力和前庭功能。本次研讨会汇集了研究各种器官系统(无脊椎动物的外体、耳蜗、前庭和侧线系统)中的毛细胞并利用各种实验方法(包括分子发育分析、基因表达扰动和电生理学等)的研究人员，目的是启动关于毛细胞功能、发育和进化的重要跨学科对话和思想交流。例如，在囊状海鞘(一种非脊椎动物脊索动物)中发现感觉毛细胞，促进了重要的进化发育研究，揭示了脊椎动物头盖骨中毛细胞发育的共同特征。在脊椎动物中，耳蜗毛细胞和前庭毛细胞来自耳道胎盘，而侧线系统的毛细胞来自侧线胎盘。在这些不同的环境中，毛细胞发育和分化所需的基因的分子分析正在进行中，同时也在努力确定负责内耳毛细胞机械-电子转导的一个或多个离子通道。因此，现在是将来自这些不同社区的研究人员聚集在一起的一个非常好的时机，共同的目的是向生物学教师及其研究生和本科生广泛传播关于毛细胞的新信息，他们都是SICB会议的主要参与者，并促进新的科学合作，这将导致对毛细胞进化、发育、生理和再生的基本问题采取新的方法。