Shaping of Nanotubules Formed by Amino Acid Amphiphiles

氨基酸两亲物形成的纳米管的成形

• 批准号: 233624625
• 负责人: Professor Dr. Michael Gradzielski
• 金额: --
• 依托单位: Arbeitsgruppe Physikalische Chemie/ Molekulare Materialwissenschaften
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/233624625?language=en
• 关键词: Shaping; Nanotubules; Formed; Amino; Acid

Self-assembled nanotubes are highly interesting colloidal systems due to their well-defined structural characteristics and typically simple formation by a bottom-up process. Yet, so-far, these structures have been studied only scarcely and their detailed aggregation properties are still poorly understood. Our project aims for an in-depth investigation of the formation of self-assembled nanotubes made of peptide-mimetic amphiphiles (amino acid amphiphiles, AAAs), and involves molecular design and analysis in two principal directions. For this comprehensive approach we will bring together the complementary expertise of the Technion (D. Danino) and TUB (M. Gradzielski) group in the fields of self-assembly and its characterisation. In the first direction we will establish relations between the tendency to form nanotubes, and the molecular architecture and chemical motifs of the designed AAAs. This will involve systematic variations of the amphiphile structure, where the synthetic work required will be shared between the labs. Subsequently a detailed characterization of the aggregate structure by direct imaging (microscopy), scattering, calorimetry and spectroscopy methods will be done to access features at the nm- and µm-scale. Here in particular the complementarity of direct imaging (TEM, Technion) and scattering techniques (TUB) is important for obtaining a detailed structural picture. From these results correlations between the mesoscopic structure and the molecular build-up of the AAAs will be derived. For that, as throughout the whole research project, an intense and frequent exchange of research results will be done, in order to optimise the joint research progress.In addition, state-of-the-art time-resolved cryo-TEM, SANS and SAXS experiments will be done in a complementary fashion to allow following the kinetics of the structural transitions and to determine intermediate structures. This is of key importance for the understanding of the driving forces of self-assembly and the pathways involved in nanotube formation. Such knowledge then is the essential for optimising nanotube formation in a rational way. In the second direction we will study to what extent the assembly process of our tailor-made AAAs can be controlled by the solution properties (solvent quality) or the addition of polymer surfactants as structure directing agents. This shall allow for a simple way to access tailor-made tubules with tuneable, well-controlled radii and wall thickness, but employing a given type of AAA.Based on this work we will investigate the potential of these nanotubes as templates for forming novel materials. This will be done in an exploratory way for forming Ag and titania/silica rods or tubules as interesting colloids. Thus, this project will yield a fundamental and comprehensive understanding of the molecular bottom-up approach for forming self-assembled nanotubes, and bringing them closer to applications as novel colloidal systems.

自组装纳米管是一种非常有趣的胶体体系，因为它们具有明确的结构特征，通常通过自下而上的过程简单地形成。然而，到目前为止，对这些结构的研究还很少，对它们的详细聚集性质仍然知之甚少。我们的项目旨在深入研究由模拟多肽的两亲分子(氨基酸两亲分子，AAA)组成的自组装纳米管的形成，并从两个主要方向进行分子设计和分析。对于这一全面的方法，我们将汇集Technion(D.Danino)和Tub(M.Gradzielski)在自组装及其表征领域的互补专业知识。在第一个方向中，我们将建立形成纳米管的趋势与所设计的AAA的分子结构和化学基序之间的关系。这将涉及两亲性结构的系统变化，其中所需的合成工作将在实验室之间分担。随后，将通过直接成像(显微镜)、散射、量热和光谱方法对聚集体结构进行详细表征，以获取纳米和微米尺度的特征。这里，尤其是直接成像(TEM，Technion)和散射技术(TUB)的互补性对于获得详细的结构图像是重要的。根据这些结果，将得出介观结构和AAA的分子构筑之间的关联。为此，在整个研究项目中，将进行密集和频繁的研究结果交流，以优化联合研究进展。此外，最先进的时间分辨低温电子显微镜、SANS和SAXS实验将以互补的方式进行，以便能够跟踪结构转变的动力学并确定中间结构。这对于理解自组装的驱动力和形成纳米管的途径至关重要。因此，这些知识是以合理的方式优化纳米管形成的关键。在第二个方向，我们将研究我们量身定做的AAA的组装过程在多大程度上可以通过溶液性质(溶剂质量)或添加聚合物表面活性剂作为结构导向剂来控制。这将允许一种简单的方法来获得定制的具有可调的、良好控制的半径和壁厚的管子，但使用给定类型的AAA。在此工作的基础上，我们将研究这些纳米管作为模板形成新材料的潜力。这将以一种探索性的方式完成，以形成银和二氧化钛/二氧化硅棒或管作为有趣的胶体。因此，该项目将对分子自下而上形成自组装纳米管的方法有一个基本和全面的了解，并使它们更接近于作为新型胶体系统的应用。