SBIR Phase I: Development of a textile-based retrievable stent for stroke that can be personalized to a patient's clot burden and retrieve long clots using torsion.

这个小型企业创新研究(SBIR)项目的更广泛的影响/商业潜力是重要的，因为它提供了一种颠覆性的新机械方法来治疗中风。美国每年有79.5万例中风，欧洲有170万例中风，全球有近2050万例中风。这种公私伙伴关系预计将通过拯救生命，特别是老年人的生命和减轻纳税人中风的经济负担，对社区产生重要的积极社会影响。这种救生设备具有独特的价值，适用于医疗系统，从单一尺寸的设备中获得较低的库存成本，并适用于血管重新开通率更高的患者，从而节省脑细胞。这种以纺织品为基础的编织可回收支架，也被称为取栓器或血栓切除辅助装置，是一项创新，将加强对个性化药物如何改变美国和世界范围内中风患者护理的科学技术理解。这个SBIR第一阶段项目计划将行业推向市场？S最长的血栓取回器，用于取出短血栓和长血栓，操作者可以根据每个患者定制？S血栓负担。此外，它还是第一款基于纺织品的编织可回收支架，可与美国开发的用于血栓治疗的标准导管抽吸系统很好地配合使用，该系统可针对所有血栓长度进行个性化处理。中风是导致全球550万人死亡的主要问题，目前还没有经济有效的治疗方法。每个中风患者的平均终身医疗成本为140,048美元。基于织物的血栓取回器(又名血栓摘除辅助装置)是一种性价比高的医疗设备，可以帮助挽救中风患者S的生命。该项目的方法和途径是通过临床前测试，与现有批准的治疗方法相比，比较基于纺织品的医疗设备重新打开被血栓堵塞的血管的能力。研究的目标和范围将集中在快速重新开放被血栓堵塞的血管的能力上。这为使用可定制的中风治疗设备的个性化医疗铺平了道路，该设备可以针对患者-S血栓负担。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research(SBIR) project is significant as it offers a disruptive new mechanical approach to stroketreatment. Each year, 795,000 strokes occur in the U.S., 1.7 million strokes in Europe, andnearly 20.5 million strokes worldwide. This public-private partnership is expected to have animportant positive societal impact on the community by saving lives especially the elderly anddecreasing the economic burden of stroke on the taxpayer. This life-saving device has a uniquevalue proposition for health-systems with lower inventory costs from a single size device, andfor patients with better vessel re-opening rates, thereby saving brain cells. This textile-basedbraided retrievable stent, also known as an embolus retriever or thrombectomy-assist device isan innovation that will enhance scientific and technological understanding of how personalizedmedicine can transform the care of stroke patients in the U.S. and worldwide.This SBIR Phase I project proposes to bring to market the industry?s longest blood clotor embolus retriever for removal of short and long clots that can be customized by the operatorbased on each patient?s clot burden. In addition, it is the first textile-based braided retrievablestent which works well in conjunction with standard catheter-based aspiration systems for stroketreatment developed in the U.S. that can be personalized to all clot lengths. Stroke is a majorproblem causing 5.5 million deaths worldwide and currently there is no cost-effective andefficacious treatments. The mean lifetime healthcare cost per stroke patient is $140,048. Thistextile-based clot retrieval device (aka thrombectomy-assist device) is a cost-effective medicaldevice that can help save a stroke patient?s life. The methods and approaches of this project isto compare via pre-clinical tests the ability of a textile-based medical device to re-open vesselsblocked with clots compared with existing approved treatments. The goals and scope of theresearch will focus on the ability to rapidly re-open vessels that are blocked by clots. This pavesthe way for personalized medicine with a customizable stroke treatment device that can betailored to a patient?s clot burden.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.