SBIR Phase I: Development of a textile-based retrievable stent for stroke that can be personalized to a patient's clot burden and retrieve long clots using torsion.

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The broader impact/commercial potential of this Small Business Innovation Research(SBIR) project is significant as it offers a disruptive new mechanical approach to stroketreatment. Each year, 795,000 strokes occur in the U.S., 1.7 million strokes in Europe, andnearly 20.5 million strokes worldwide. This public-private partnership is expected to have animportant positive societal impact on the community by saving lives especially the elderly anddecreasing the economic burden of stroke on the taxpayer. This life-saving device has a uniquevalue proposition for health-systems with lower inventory costs from a single size device, andfor patients with better vessel re-opening rates, thereby saving brain cells. This textile-basedbraided retrievable stent, also known as an embolus retriever or thrombectomy-assist device isan innovation that will enhance scientific and technological understanding of how personalizedmedicine can transform the care of stroke patients in the U.S. and worldwide.This SBIR Phase I project proposes to bring to market the industry?s longest blood clotor embolus retriever for removal of short and long clots that can be customized by the operatorbased on each patient?s clot burden. In addition, it is the first textile-based braided retrievablestent which works well in conjunction with standard catheter-based aspiration systems for stroketreatment developed in the U.S. that can be personalized to all clot lengths. Stroke is a majorproblem causing 5.5 million deaths worldwide and currently there is no cost-effective andefficacious treatments. The mean lifetime healthcare cost per stroke patient is $140,048. Thistextile-based clot retrieval device (aka thrombectomy-assist device) is a cost-effective medicaldevice that can help save a stroke patient?s life. The methods and approaches of this project isto compare via pre-clinical tests the ability of a textile-based medical device to re-open vesselsblocked with clots compared with existing approved treatments. The goals and scope of theresearch will focus on the ability to rapidly re-open vessels that are blocked by clots. This pavesthe way for personalized medicine with a customizable stroke treatment device that can betailored to a patient?s clot burden.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.