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Phase II IUCRC at University of Kentucky: Center for Arthropod Management Technologies (CAMTech)

肯塔基大学 IUCCRC 第二阶段：节肢动物管理技术中心 (CAMTech)

基本信息

批准号：
1821936
负责人：
Subba Palli
金额：
$ 60万
依托单位：
University of Kentucky Research Foundation
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1821936&HistoricalAwards=false
关键词：
Phase II IUCRC University Kentucky

项目摘要

The development of new pest management approaches is critical for the production of sufficient food for the increasing human population, and for prevention of arthropod-transmitted disease to plants and humans. The more widespread pest distribution associated with changing climatic conditions exacerbates the need for new pest management tools. The economic losses associated with the activities of arthropods and nematodes are a significant burden to society through both agricultural losses and human health costs. The Center for Arthropod Management Technologies (CAMTech) addresses issues that limit effective management of the major insect and nematode pests that impact agriculture and human health. The center addresses the need for specific knowledge and research tools to expedite delivery of pest management solutions by industry partners to the marketplace, and to investigate both new approaches, and expansion of existing approaches for pest suppression. The major limitations in the field are common to the agricultural biotechnology and urban pest management industries and restrict widespread adoption of strategies shown to be effective in some systems. The center contributes key advances through state of the art, industrially relevant research and by training of graduate students and postdoctoral researchers including underrepresented groups, toward continued advancement of the field. CAMTech serves as a platform for innovative, interdisciplinary research activities at the interface of academia, government, and industry. Expertise in entomology and other departments at the University of Kentucky include insect physiology, genomics, population genetics, vector biology, and symbiosis. The research needs of industries in the agricultural biotechnology and human health domains align well with the expertise of university participants providing for the expedited development of pest management solutions to the benefit of agricultural sustainability and public wellbeing. Advanced methods including next-generation sequencing and -omics, confocal microscopy, RNA interference and genome editing are employed to conduct non-competitive research of crucial importance to the industrial sector. The research products are transferred to member companies through quarterly reports and presentations at bi-annual IAB meetings and to the public in the form of publications and presentations at conferences. Fundamental knowledge gained from center research on mechanisms of RNA interference, insecticide resistance, toxicological effects of insecticides, physiological processes of pests and disease vectors facilitate R&D efforts of industry and expedite the development of new products for pest and disease vector control.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

开发新的害虫管理方法对于为不断增加的人口生产足够的食物以及预防节肢动物传播的植物和人类疾病至关重要。随着气候条件的变化，害虫分布更加广泛，这加剧了对新的害虫管理工具的需求。与节肢动物和线虫活动相关的经济损失是社会的重大负担，既包括农业损失，也包括人类健康成本。节肢动物管理技术中心（CAMTech）致力于解决限制对影响农业和人类健康的主要昆虫和线虫害虫进行有效管理的问题。该中心解决了对特定知识和研究工具的需求，以加快行业合作伙伴向市场提供害虫管理解决方案，并调查新方法和现有害虫抑制方法的扩展。农业生物技术和城市害虫管理行业在这一领域的主要局限性是共同的，并限制了在某些系统中证明有效的战略的广泛采用。该中心通过最先进的技术，工业相关的研究和培养研究生和博士后研究人员，包括代表性不足的群体，促进该领域的持续发展。CAMTech是学术界，政府和工业界之间创新，跨学科研究活动的平台。肯塔基州大学的昆虫学和其他部门的专业知识包括昆虫生理学，基因组学，种群遗传学，载体生物学和共生。农业生物技术和人类健康领域的行业研究需求与大学参与者的专业知识保持一致，从而加快制定有害生物管理解决方案，以促进农业可持续性和公共福祉。先进的方法，包括下一代测序和组学，共聚焦显微镜，RNA干扰和基因组编辑被用来进行对工业部门至关重要的非竞争性研究。研究成果通过季度报告和在一年两次的IAB会议上的演示文稿传递给成员公司，并以出版物和会议演示文稿的形式传递给公众。从RNA干扰机制、杀虫剂抗性、杀虫剂的毒理学效应、害虫和病媒的生理过程等中心研究中获得的基础知识促进&了工业界的研发工作，并加快了害虫和病媒控制新产品的开发。该奖项反映了NSF的法定使命，并通过利用基金会的智力价值和更广泛的评估，被认为值得支持。影响审查标准。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects.

DOI：
10.1073/pnas.1809381115
发表时间：
2018-08-14
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Yoon JS;Mogilicherla K;Gurusamy D;Chen X;Chereddy SCRR;Palli SR
通讯作者：
Palli SR

Midgut-specific expression of CYP321A8 P450 gene increases deltamethrin tolerance in the fall armyworm Spodoptera frugiperda