A conserved pathway of cell death in response to invading DNA

响应 DNA 入侵的保守细胞死亡途径

• 批准号: DP160101721
• 负责人: A/Prof Katryn Stacey
• 金额: $ 24.95万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101721
• 关键词: conserved; pathway; cell; death; response

This project aims to characterise molecular details of a new pathway of foreign DNA recognition and rapid cell death. Recognition of foreign DNA is a key means by which both bacteria and eukaryotic cells can detect infections, as well as guard their own genome. Eukaryotic cell DNA is sequestered in the nucleus and organelles, and any DNA found in the cytosol is a danger signal. The project proposes that cytosolic DNA-induced cell death is a fundamental eukaryotic defensive response, but surprisingly, the known pathway is restricted to macrophages of some mammals. Project outcomes may be applied to protein expression yield in biotechnology or advances in gene therapy.

该项目旨在研究外源DNA识别和快速细胞死亡的新途径的分子细节。识别外源DNA是细菌和真核细胞检测感染以及保护自身基因组的关键手段。真核细胞DNA被隔离在细胞核和细胞器中，任何在细胞质中发现的DNA都是危险信号。该项目提出，胞质DNA诱导的细胞死亡是一种基本的真核防御反应，但令人惊讶的是，已知的途径仅限于一些哺乳动物的巨噬细胞。项目成果可应用于生物技术中的蛋白质表达产量或基因治疗的进展。