Infection Biology and Epidemiology of Staphylococci and Staphylococcal Diseases in sub-Saharan Africa
撒哈拉以南非洲葡萄球菌和葡萄球菌疾病的感染生物学和流行病学
基本信息
- 批准号:234518095
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2013
- 资助国家:德国
- 起止时间:2012-12-31 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Staphylococcus aureus causes severe infections in healthy and compromised persons. In developed countries, S. aureus is a community or hospital acquired pathogen, and clones with broad antimicrobial resistance are nowadays widespread and limiting therapeutic options. Investigations on the distribution of the pathogen as well as on its genetic and biologic characteristics, however, are relatively limited to developed regions while in tropical areas with sparse resources such as in sub-Sahara Africa only limited data on the pathogen and its associated disease are available.First indications on the toxin equipment of isolates from Africa demonstrate that in these regions phylogenetic different lineages appear to be prominent. Accordingly, as its goal the African-German StaphNet intents by application of comparative analyses of African and German isolates both of clinical and commensal origin as well as by determination of host response to contribute to an enhanced understanding of mechanisms and course of disease. To this end, during the first funding period three African and five German research institutes and their affiliated hospitals have collected clinically well-defined S. aureus isolates from Western, Eastern, and Southern Africa as well as from Germany, and have analyzed these isolates with extended molecular methods. Apart from the demonstrated prevalence of the Panton-Valentine-Leukocidin also in isolates from remote indigenous African populations, the presence of isolates with resistance profiles typically for human colonizers even in non-human primates from sanctuaries has been a novel, unexpected result with potential wide-ranging implications. For the applied new funding period, additional detailed investigations of the now available >1000 staphylcoccal isolates and additional clinical material is planned. By application of modern genomic analyses in conjunction with gene expression and function assays, and supported by modern bioinformatic analysis, these investigations shall now reveal the importance of staphylococcal gene products and the mechanisms of humoral and innate immune defence which may be associated with onset and course of staphylococcal disease in Africa.The project heavily relies on a concept of bidirectional technology exchange and capacity building enabling both African and German partners to address (basic) research topics in staphylococcal biology and associated infectious disease under specific consideration of the conditions of such research in tropical countries with limited resources.
金黄色葡萄球菌会对健康人和受感染的人造成严重感染。在发达国家,金黄色葡萄球菌是一种社区或医院获得性病原体,具有广泛的抗菌素耐药性的克隆体目前普遍存在,限制了治疗选择。然而,对病原体的分布及其遗传和生物学特征的调查相对局限于发达地区,而在资源稀少的热带地区,如撒哈拉以南非洲,只有有限的关于病原体及其相关疾病的数据。关于非洲分离株毒力设备的首次迹象表明,在这些地区,系统发育不同的谱系似乎很突出。因此,非洲-德国STAPHNET的目标是通过应用对非洲和德国临床和共生来源的分离株的比较分析以及通过确定宿主反应来促进对疾病机制和病程的更好了解。为此,在第一个资助期间,三个非洲研究机构和五个德国研究机构及其附属医院从西非、东部和南部非洲以及德国收集了临床明确的金黄色葡萄球菌分离物,并用扩展的分子方法对这些分离物进行了分析。除了证明潘顿-瓦伦丁-白血球蛋白在非洲偏远土著人口的分离物中也有流行之外,即使在保护区的非人类灵长类动物中,也存在典型的人类殖民者抗性特征的分离物的存在是一个新的、意想不到的结果,具有潜在的广泛影响。在申请新的资金期间,计划对目前可用的>;1000葡萄球菌分离株和额外的临床材料进行更多详细的调查。通过结合基因表达和功能分析应用现代基因组分析,并在现代生物信息学分析的支持下,这些调查现在将揭示葡萄球菌基因产品的重要性以及可能与非洲葡萄球菌疾病的发病和病程有关的体液和先天免疫防御机制。该项目严重依赖双向技术交流和能力建设的概念,使非洲和德国伙伴能够在具体考虑到热带国家资源有限的情况下解决葡萄球菌生物学和相关传染病的(基础)研究课题。
项目成果
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Professor Dr. Markus Bischoff, since 6/2016其他文献
Professor Dr. Markus Bischoff, since 6/2016的其他文献
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