MRI: Acquisition of a Laser-Based Biomolecular Imager

MRI：获取基于激光的生物分子成像仪

• 批准号: 1828193
• 负责人: Karen Buchmueller
• 金额: $ 15.69万
• 依托单位: Furman University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828193&HistoricalAwards=false
• 关键词: MRI; Acquisition; Laser; Based; Biomolecular

An award is made to Furman University to support the acquisition of a biomolecular imager for shared use amongst faculty, staff and students in the Biology and Chemistry departments. Faculty in the Biology and Chemistry departments at Furman University are committed to maintaining strong undergraduate research programs that positively impact the long-term training and development of the next generations of scientists. To provide these experiences, faculty are actively engaged in novel research programs and in the mentorship of undergraduate students in the lab. The new imager system will positively impact at least 35 undergraduate researchers each year and support programs funded through NSF-Research Experiences for Undergraduates. It will enable research experiences for high school teachers and students. In addition, faculty and undergraduates from historically black colleges and universities in the region, two-year colleges, and other regional undergraduate institutions will have access to the bioimager for their research needs. Furman faculty have wide-ranging research projects that include the biophysical characterization of AT-hook containing proteins; the elucidation of the role for desmosomes in the coordination of cell migration; investigating compounds of sulfur and selenium for their ability to protect DNA from reactive oxygen species damage; characterizing the DNA adduct and DNA photocleavage properties of novel Cr (III)-diimine complexes; studying the stress response of a fungal pathogen; elucidating the roles of chromatin condensation and decondensation in T-cell activity; and conducting genetic fingerprinting of sea anemones exposed to environmental stressors. The new imager system will aid all of these efforts by improving data acquisition speed, sensitivity, quality, and flexibility. Faculty research will result in presentations at meetings within their respective fields and publications in nationally-disseminated, peer-reviewed journals.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

福曼大学获得了一个奖项，以支持获得生物分子成像仪，供生物和化学系的教职员工和学生共享使用。弗曼大学生物学和化学系的教师致力于保持强大的本科研究项目，这些项目对下一代科学家的长期培训和发展产生积极影响。为了提供这些经验，教师积极参与新颖的研究项目，并在实验室本科生的导师。新的成像系统每年将对至少35名本科生研究人员产生积极影响，并支持通过NSF本科生研究经验资助的项目。它将使高中教师和学生的研究经验。 此外，来自该地区历史悠久的黑人学院和大学、两年制学院和其他地区本科院校的教师和本科生将有机会使用生物成像仪进行研究。弗曼学院有广泛的研究项目，包括AT-钩含蛋白质的生物物理特性;阐明桥粒在细胞迁移协调中的作用;调查硫和硒的化合物保护DNA免受活性氧损伤的能力;表征新型Cr（III）-二亚胺络合物的DNA加合物和DNA光裂解特性;研究真菌病原体的应激反应;阐明染色质浓缩和去浓缩在T细胞活动中的作用;以及对暴露于环境应激物的海葵进行遗传指纹分析。新的成像仪系统将通过提高数据采集速度、灵敏度、质量和灵活性来帮助所有这些努力。 教师的研究成果将在各自领域的会议上发表，并在全国范围内传播的同行评审期刊上发表。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。