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MRI: Acquisition of Enhanced Mass Spectroscopy Capabilities at Portland State University

MRI：波特兰州立大学增强质谱能力

基本信息

批准号：
1828573
负责人：
Dirk Iwata-Reuyl
金额：
$ 35万
依托单位：
Portland State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828573&HistoricalAwards=false
关键词：
MRI Acquisition Enhanced Mass Spectroscopy

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Dirk Iwata-Reuyl from Portland State University and colleagues Robert Strongin, Daniel Ballhorn, David Stuart and Theresa McCormick have acquired a high-performance benchtop quadrupole orbitrap mass spectrometer with a front-end ion trap that is capable of tandem mass spectrometry, and equipped with a direct analysis in real time (DART) source. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex matrices. In a typical experiment, the components flow into a mass spectrometer where they are ionized and the ion masses are measured. This highly sensitive technique allows detection and determination of the structure of molecules in a complex mixture. The DART source is used for rapid analysis of a wide variety of samples at atmospheric pressure and in the open laboratory environment. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse students in research and research training using this modern analytical technique. This is a multi-user, multi-departmental (and multi-institutional) facility that enhances active interdisciplinary activities. Students enrolled in an advanced instrumentation course at PSU are trained on the instrument and use. Among the programs designed to broaden participation by women and underrepresented groups in STEM education and research are the programs Ronald E. McNair Scholars, Enhancing cross-disciplinary infrastructure training at Oregon, and the Louis Stokes Alliance for Minority Participation. In addition to the training that this facility provides to undergraduate and graduate students at PSU, faculty and students from nearby 4-year institutions also have access to the instrument as do high school science teachers involved in summer internships.The proposal is aimed at enhancing research and education at all levels. It especially impacts studies on the formation and function of chemically modified nucleosides in transfer RNA and investigations on redox and chromophore materials and mechanisms in molecular sensors and probes. The mass spectrometer is used for studies of interactions between organisms of different trophic levels and for developing catalysts for solar fuel generation using hetero-ligated nickel-pyridinethiolate catalysts. The instrument also aids researchers developing reactions with hipervalent diaryliodonium reagents, and those developing screening tests and evaluating new compounds having medical potential.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。波特兰州立大学的Dirk Iwata-Reuyl教授及其同事Robert Strongin， Daniel Ballhorn， David Stuart和Theresa McCormick已经获得了一台高性能台式四极轨道阱质谱仪，该质谱仪具有前端离子阱，能够进行串联质谱分析，并配备了直接实时分析（DART）源。一般来说，质谱（MS）是用于鉴定和表征复杂基质中少量化学物质的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被电离，离子质量被测量。这种高度灵敏的技术可以检测和确定复杂混合物中的分子结构。DART源用于在大气压和开放实验室环境下对各种样品进行快速分析。此次收购加强了大学和地区的研究基础设施。该仪器通过让不同的学生参与使用这种现代分析技术的研究和研究训练，扩大了参与范围。这是一个多用户、多部门（和多机构）的设施，可以促进积极的跨学科活动。参加PSU高级仪器课程的学生将接受仪器和使用方面的培训。旨在扩大女性和代表性不足群体参与STEM教育和研究的项目包括罗纳德·e·麦克奈尔学者项目、俄勒冈州加强跨学科基础设施培训项目和路易斯·斯托克斯少数民族参与联盟项目。除了该设施为PSU的本科生和研究生提供培训外，附近四年制院校的教师和学生以及参加暑期实习的高中科学教师也可以使用该仪器。该建议旨在加强各级的研究和教育。它特别影响了转移RNA中化学修饰核苷的形成和功能的研究，以及分子传感器和探针中氧化还原和发色团材料和机制的研究。质谱计用于研究不同营养水平的生物之间的相互作用，并用于开发使用杂连接镍吡啶硫代催化剂的太阳能燃料生成催化剂。该仪器还帮助研究人员开发与低价二芳碘鎓试剂的反应，以及开发筛选测试和评估具有医疗潜力的新化合物的研究人员。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。