SBIR Phase II: A suite of flexible printed MRI coils for newborn to adult patients

SBIR II 期：一套适用于新生儿到成人患者的柔性印刷 MRI 线圈

• 批准号: 1831253
• 负责人: Joseph Corea
• 金额: $ 75万
• 依托单位: InkSpace Imaging, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831253&HistoricalAwards=false
• 关键词: SBIR; Phase; II; suite; flexible

This Small Business Innovation Research (SBIR) Phase II project aims to develop a suite of screen-printed receive coils for Magnetic Resonance Imaging (MRI), that are flexible, lightweight, low-cost and adapted to the entire population from infants to adults. MRI is widely used to establish a broad variety of clinical diagnosis, but suffers from long examination times and a high rate of failure, resulting in a yearly loss of more than $4 billion in the United States alone. Printed receive coils are extremely flexible, lightweight, and conform well to the human body. With this technology, coils can be designed and manufactured inexpensively to fit all patient sizes, thus improving image quality and enabling robust acceleration of the method. These benefits can contribute to increase the success rate of MRI exams, speed up procedure time, enhance the clinical workflow, and reduce equipment costs. Printed coils will improve the quality of care offered by MRI suites and increase the availability and use of MRI to a wider patient population. Overall, this project will develop a clinical-ready system capable of delivering the full economic and clinical benefits of printed coils, which will contribute to a reduction of the healthcare costs associated with MRI.This project aims to fully realize a clinical-ready system consisting of a collection of printed, flexible lightweight MRI coil arrays, and connecting to a single universal cable to interface with the MRI scanner. A first part of the project will focus on the design of the cable and the associated connection scheme allowing interchange of multiple printed coil arrays of different sizes. Different strategies will be examined with the intent of maintaining high performance and safety while maximizing the advantages brought by printing. A second project goal will focus on the development of a collection of printed coil arrays for patient sizes ranging from newborn to adult, that are compatible with the universal cable and for both 3T and 1.5T scanners. The arrays will be designed for body imaging and will consist of 32-channel devices divided into 16-channel posterior and anterior portions. Their performance will be compared to a commercial 32-channel product. The final system will meet all the safety requirements for medical use and will be ready to be manufactured at scale.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业创新研究(SBIR)第二阶段项目旨在开发一套用于磁共振成像(MRI)的丝网印刷接收线圈，该线圈灵活、轻便、低成本，适合从婴儿到成年人的所有人群。核磁共振被广泛用于建立各种各样的临床诊断，但检查时间长，失败率高，仅在美国每年就造成超过40亿美元的损失。印刷接收线圈非常灵活，重量轻，与人体很好地吻合。有了这项技术，线圈可以低成本地设计和制造，以适应所有患者的大小，从而提高图像质量并实现方法的强劲加速。这些好处有助于提高MRI检查的成功率，加快程序时间，增强临床工作流程，并降低设备成本。打印线圈将提高MRI套件提供的护理质量，并使更多的患者能够获得和使用MRI。总体而言，该项目将开发一个能够提供印刷线圈的全部经济和临床好处的临床就绪系统，这将有助于降低与MRI相关的医疗成本。该项目旨在完全实现一个临床就绪系统，该系统由一组印刷的、灵活的轻型MRI线圈阵列组成，并连接到一根通用电缆以与MRI扫描仪接口。该项目的第一部分将侧重于电缆和相关连接方案的设计，该方案允许互换不同尺寸的多个印刷线圈阵列。将审查不同的战略，目的是保持高性能和安全，同时最大限度地发挥印刷带来的优势。第二个项目目标将侧重于开发一系列印刷线圈阵列，适用于从新生儿到成人的患者大小，与通用电缆兼容，并可用于3T和1.5T扫描仪。这些阵列将为人体成像而设计，并将由32个通道设备组成，分为16个通道的后部和前部。他们的性能将与商业32声道产品进行比较。最终的系统将满足所有医疗使用的安全要求，并将准备好大规模生产。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。