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Excellence in Research (EiR): Radical Scavenging Interactions of Carbon Nanodots and Smart Polymer-Carbon Nanodots Systems

卓越研究（EiR）：碳纳米点和智能聚合物-碳纳米点系统的自由基清除相互作用

基本信息

批准号：
1832134
负责人：
John Bang
金额：
$ 99.95万
依托单位：
North Carolina Central University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1832134&HistoricalAwards=false
关键词：
Excellence Research EiR Radical Scavenging

项目摘要

Carbon nanodots are a type of newly engineered non-toxic nanomaterials. They have scavenging potential of free radicals, which are highly unstable and reactive molecules, in biological systems and other environments. Because free radicals are associated with inflammation, which can lead to potentially serious pathological conditions, a better understanding of the interfacial reaction mechanisms between carbon nanodots and biological systems is a critical step toward using these nanomaterials in applications. This project will enhance the understanding of the surface chemistry of carbon nanodots and the roles of the surrounding conditions on carbon nanodots interfacial reactions in biological systems. Additionally, the data on free radical life cycle from this study will help guide experiments and computational modeling in other investigations of nanomaterials for biomedical engineering applications. Broader impacts of the findings from the proposed study include: 1) Development of customized nanoscale materials for biomedical and, potentially, environmental applications, 2) Hands-on training of under-represented STEM students throughout the projects and curriculum revision that can be scaled up in other STEM oriented institutions, and 3) Impact on the K-12 science and engineering education in under-represented educational communities through the PIs network.The goal of this study is to better understand how carbon nanodot's free radical scavenging potential is influenced by surrounding biological systems and biochemical conditions. The scope of the proposed work will be mainly limited to delineating the mechanisms involved in interfacial interactions. This will be done by investigating reactions between functional groups on carbon nanodots and biological/biochemical molecules. This study will be carried out by using carbon nanodots with various functional groups, polymer-protein conjugates and hybrids, and spin-trap protein radicals with three thrusts: 1) Synthesis and preparation of carbon nanodots, conjugates and hybrids, and spin-trap protein radicals, 2) Evaluation of anti-oxidative activities of the prepared molecules in biological system, and 3) Computational modeling of calorimetric techniques with empirical data. The intellectual merit of this study is to advance our understanding in the following areas: 1) Interfacial and intermolecular reaction chemistry and fundamentals of free radical reactions between nanomaterials, especially carbon nanodots and biological systems, 2) Free radical life cycle mechanisms by building computational models, which can also be applied to other similar engineered nanomaterial studies, and 3) Reaction mechanisms associated with molecules and protein radicals from immune-spin trap methods that overcome technical challenges currently present in many free radical studies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

碳纳米点是一种新型的无毒纳米材料。它们具有清除自由基的潜力，自由基是生物系统和其他环境中高度不稳定和反应性的分子。由于自由基与炎症有关，这可能导致潜在的严重病理状况，因此更好地了解碳纳米点和生物系统之间的界面反应机制是将这些纳米材料用于应用的关键一步。本项目将提高对碳纳米点表面化学的理解，以及周围条件对生物系统中碳纳米点界面反应的作用。此外，本研究中有关自由基生命周期的数据将有助于指导生物医学工程应用纳米材料的其他研究中的实验和计算建模。拟议研究结果的更广泛影响包括：1）开发用于生物医学和潜在环境应用的定制纳米材料，2）在整个项目和课程修订过程中对代表性不足的STEM学生进行实践培训，这些项目和课程修订可以在其他STEM导向机构中扩大，和3）对K-12科学和工程教育的影响，本研究的目的是更好地了解碳纳米点如何清除自由基，电位受周围生物系统和生化条件的影响。拟议的工作范围将主要限于划定界面相互作用所涉及的机制。这将通过研究碳纳米点上的官能团与生物/生物化学分子之间的反应来完成。这项研究将通过使用具有各种官能团的碳纳米点，聚合物-蛋白质缀合物和杂交物以及具有三个推力的自旋捕获蛋白质自由基来进行：1）碳纳米点、缀合物和杂化物以及自旋捕获蛋白质自由基的合成和制备，2）评价所制备的分子在生物系统中的抗氧化活性，和3）用经验数据对量热技术进行计算建模。这项研究的学术价值是促进我们在以下领域的理解：1）纳米材料，特别是碳纳米点与生物系统之间的界面和分子间反应化学和自由基反应的基本原理，2）通过建立计算模型的自由基生命周期机制，这也可以应用于其他类似的工程纳米材料研究，和3）免疫自旋捕捉方法中分子和蛋白质自由基的反应机制，克服了目前许多自由基研究中存在的技术挑战。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。