Azide-based Strategies for the Diversity-Oriented Synthesis of Macrocyclic Scaffolds

这一研究项目是对化学遗传学的贡献，化学遗传学包括利用合成物质研究生物系统。为此目的，将通过基于叠氮官能团的多能反应性的面向多样性的合成来合成大量的有机大环分子。随后，将对合成的化合物进行生物活性测试(例如，对多重耐药病原体的抗菌活性)并进行进一步优化。

This research project represents a contribution to chemical genetics which comprises the study of biological systems using synthetic substances. For this purpose a huge collection of organic, macrocyclic molecules will be synthesized via diversity-oriented synthesis based on the pluripotent reactivity of the azide functionality. Subsequently, the synthesized compounds will be tested on their biological activity (e.g. antibacterial activity against multiresistent pathogens) and further optimised.