Azide-based Strategies for the Diversity-Oriented Synthesis of Macrocyclic Scaffolds

基于叠氮化物的大环支架多样性合成策略

• 批准号: 235232490
• 负责人: Dr. David Wilcke
• 金额: --
• 依托单位: Yusuf Hamied Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/235232490?language=en
• 关键词: Azide; based; Strategies; Diversity; Oriented

This research project represents a contribution to chemical genetics which comprises the study of biological systems using synthetic substances. For this purpose a huge collection of organic, macrocyclic molecules will be synthesized via diversity-oriented synthesis based on the pluripotent reactivity of the azide functionality. Subsequently, the synthesized compounds will be tested on their biological activity (e.g. antibacterial activity against multiresistent pathogens) and further optimised.

该研究项目代表了对化学遗传学的贡献，其中包括使用合成物质研究生物系统。为了这个目的，大量的有机大环分子将通过基于叠氮化物官能团的多能反应性的多样性定向合成来合成。随后，将测试合成的化合物的生物活性（例如对多重耐药病原体的抗菌活性）并进一步优化。