Antimicrobial biomaterials from bio-based feedstocks with novel feedstock supplementation strategies

采用新型原料补充策略的生物基原料制成的抗菌生物材料

• 批准号: 10063453
• 金额: $ 6.97万
• 依托单位: EVOLUTOR LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10063453
• 关键词: Antimicrobial; biomaterials; bio; based; feedstocks

Both the climate crisis and public health crises such as the COVID-19 pandemic are presenting substantial challenges to our communities and economies.To address the climate collapse, we need to rapidly reduce our manufacturing industries' reliance on fossil fuels and build new decarbonised supply chains that are robust and resilient in an ever-changing world.In 2016/2017 healthcare associated infections cost the NHS £2.1B, and were responsible for approximately 22,800 inpatient deaths. To protect public health and reduce the burden on health care providers, we need new technologies and products that can reduce the spread of microbial pathogens carrying healthcare associated infections such as scarlet fever, strep A and bacterial co-infections that accompany conditions like COVID-19\. As well as fulfilling these functions, new products must also be manufacturable without any reliance on fossil fuels.In this project, Evolutor is addressing these challenges by developing production processes for the manufacture of advanced and highly-functionalized biomaterials with antimicrobial properties. We will use our specialist Accelerated Evolution Platform to develop microbial production hosts that, through precision fermentation, can turn waste products into biomaterials that are fully biodegradable and biocompatible. Additionally, we will test new strategies and manufacturing processes to impart natural antimicrobial properties to these materials by supplementing fermentation feedstocks with a range of natural compounds.Through these project outputs, we will produce and analyse the performance of several small batches of novel biomaterial that:* is 100% natural;* has customizable antimicrobial functionality;* is produced from waste;* requires no direct fossil fuel input;* is completely biodegradable and non-toxic;* produces significantly less chemical pollution than conventional materials; and* can be tailored to a wide range of applications.Overall, the success of this project will drive the expansion of the UK's bioeconomy, bring us closer to a Net Zero world, and help to reduce the spread of microbial pathogens and the burden of associated healthcare costs. It will also accelerate Evolutor's ambition to build its world-leading bio-foundry Galapagos Towers in the North of England.Beyond the completion of this project, the innovations achieved will allow Evolutor to explore scaled-up manufacture of its antimicrobial biomaterials as well as conduct onward R&D of feedstock supplementation to customise material properties beyond antimicrobial functionality. Example properties include colour (for advanced clothing and construction materials), fragrance (for cosmetics and detergents), tensile strength (for industrial and construction use) and permeability (for wastewater treatment and pollution control).

气候危机和COVID-19大流行等公共卫生危机都给我们的社区和经济带来了重大挑战。为了应对气候崩溃，我们需要迅速减少制造业对化石燃料的依赖，建立新的脱碳供应链，在不断变化的世界中保持强劲和弹性。2016/2017年，医疗相关感染使NHS损失了21亿英镑，导致约22800名住院患者死亡。为了保护公众健康并减轻卫生保健提供者的负担，我们需要新的技术和产品，以减少携带猩红热、甲型链球菌和伴随COVID-19等疾病的细菌合并感染等卫生保健相关感染的微生物病原体的传播。在实现这些功能的同时，新产品还必须在不依赖化石燃料的情况下生产。在这个项目中，evoltor正在通过开发具有抗菌性能的先进和高功能化生物材料的生产工艺来解决这些挑战。我们将使用我们专业的加速进化平台来开发微生物生产宿主，通过精确发酵，可以将废物转化为完全可生物降解和生物相容性的生物材料。此外，我们将测试新的策略和制造工艺，通过在发酵原料中添加一系列天然化合物来赋予这些材料天然的抗菌性能。通过这些项目产出，我们将生产和分析几小批新型生物材料的性能，这些材料：* 100%天然；*可定制抗菌功能；*由废物产生；*不需要直接的化石燃料输入；*完全可生物降解，无毒；*比传统材料产生的化学污染少得多；并且*可以根据广泛的应用进行定制。总体而言，该项目的成功将推动英国生物经济的扩张，使我们更接近净零世界，并有助于减少微生物病原体的传播和相关医疗费用的负担。它还将加速进化公司在英格兰北部建造世界领先的生物铸造厂加拉帕戈斯塔的雄心。在完成该项目之后，所取得的创新将使evoltor能够探索其抗菌生物材料的规模化生产，并进行原料补充的进一步研发，以定制抗菌功能以外的材料特性。例如，颜色（用于高级服装和建筑材料）、香味（用于化妆品和洗涤剂）、抗拉强度（用于工业和建筑用途）和渗透性（用于废水处理和污染控制）。