RoL: FELS: RAISE: A Phylogenomically-Based Bioinspired Robotic Model Approach to Addressing the Evolution of Terrestrial Locomotion
RoL:FELS:RAISE:一种基于系统发育学的仿生机器人模型方法来解决陆地运动的进化问题
基本信息
- 批准号:1839915
- 负责人:
- 金额:$ 99.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
One clear example of a Rule of Life is evolutionary convergence, the occurrence of the same or extremely similar adaptations in independent lineages of species on the Tree of Life. The recent discovery of a blind cavefish that walks and climbs waterfalls with a salamander-like gait and has evolved a robust pelvic girdle (a kind of hip) offers an extraordinary opportunity to study, in living fishes, a pivotal event in evolutionary history. That event, the vertebrate invasion of land, hinged on the evolution of fins to limbs that enabled the first vertebrates to walk on land. The fossil record of this transition is scarce, and extant fishes were thought to lack the morphological features necessary for studying the origin of quadrupedal walking. This research will provide a unique opportunity to understand, through phylogenetic analysis and mathematical and robotic modeling, the mechanism underlying a major event in the history of life: how fishes were able to transition to a terrestrial lifestyle and evolve into the tetrapods. The broader impacts of this project will promote teaching, training, and learning for high school students in diverse and underprivileged communities. The project will also provide opportunities for graduate and undergraduate research training and make important contributions to public science education. This project was co-funded by the Biology Directorate and the Physics of Living Systems Program in the Physics Division. The proposed work will identify the genomic, morphological, and mechanical qualities that enable a fish to walk on land. Advancing previous work on the functional morphology and kinematics of terrestrial walking in the blind cave fish Cryptotora thamicola, the proposed research will examine the phylogenomic relationships, morphology, biomechanics, and walking performance from an evolutionary perspective among balitorid loaches. Genomic sequencing will determine convergent genetic markers known to be involved in pelvic girdle formation in other walking vertebrates. Morphological examinations will reveal how functional phenotypic adaptations can be formed by major genomic changes. A biorobotic model organism, validated through comparison with our experimental biomechanical data, will be used to take a modular approach to examining convergence and answering questions on the effect of pelvic morphology on walking performance in extinct fin-to-limb transitional forms and modern forms. The work proposed will discriminate the fundamental physical properties which are inherent to the transition to terrestrial walking from an aquatic form. The evolution of the terrestrial pelvic girdle was critical to the diversification of amphibians, reptiles, birds and mammals; the proposed work uses a convergent fish model to study the evolution of anatomical structures that support the vertebrate body against gravity and show how modulation of muscular control can produce a tetrapodal gait within a given range of skeletal morphologies. This research will inform scientific understanding of the mechanisms underlying the convergent evolution of morphological innovation, allowing development of a unifying principle for mass support in tetrapods based on the genomics, basic physics, and mechanics that define the pelvic girdle contribution to quadrupedal walking.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
生命法则的一个明显例子是进化趋同,即在生命树上的物种的独立谱系中发生相同或极其相似的适应。最近发现了一种盲穴居鱼,它以火蜥蜴般的步态行走和攀登瀑布,并进化出了健壮的骨盆腰带(一种臀部),这为在活着的鱼类中研究进化史上的关键事件提供了一个非同寻常的机会。那次事件,脊椎动物入侵陆地,取决于鳍到肢体的进化,使第一批脊椎动物能够在陆地上行走。关于这种转变的化石记录很少,现存的鱼类被认为缺乏研究四足行走起源所必需的形态特征。这项研究将提供一个独特的机会,通过系统发育分析以及数学和机器人建模,了解生命历史上一项重大事件背后的机制:鱼类如何能够过渡到陆地生活方式并进化为四足动物。该项目的更广泛影响将促进不同贫困社区的高中生的教学、培训和学习。该项目还将为研究生和本科生提供研究培训机会,并为公共科学教育做出重要贡献。该项目由生物局和物理部的生命系统物理学项目共同资助。这项拟议的工作将确定使鱼能够在陆地上行走的基因组、形态和机械特性。在前人对盲穴鱼隐形洞鱼陆栖行走功能形态和运动学研究的基础上,这项研究将从进化的角度研究拟步甲鱼之间的系统发育关系、形态、生物力学和行走能力。基因组测序将确定已知参与其他行走脊椎动物骨盆带形成的趋同遗传标记。形态检查将揭示主要基因组变化是如何形成功能表型适应的。通过与我们的实验生物力学数据的比较,一个生物机器人模型生物将被用来采用模块化的方法来检查收敛和回答关于骨盆形态对灭绝的鳍到肢体过渡形式和现代形式的行走能力的影响的问题。拟议的工作将区分从水生形式向陆地行走过渡所固有的基本物理特性。陆地骨盆带的进化对两栖动物、爬行动物、鸟类和哺乳动物的多样性至关重要;拟议的工作使用汇聚的鱼类模型来研究支持脊椎动物身体免受重力影响的解剖结构的演变,并展示肌肉控制的调节如何在给定的骨骼形态范围内产生四足步态。这项研究将使人们对形态创新趋同进化的机制有更科学的理解,从而在定义骨盆腰带对四足行走的贡献的基因组学、基础物理学和力学的基础上,开发出四足动物质量支持的统一原则。这一奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Catfishes of the Genus Glyptothorax (Siluriformes: Sisoridae) in the Mae Klong River Basin, Thailand, with Taxonomic Implications for Several Southeast Asian Species
- DOI:10.1643/i2022045
- 发表时间:2023-06
- 期刊:
- 影响因子:1.5
- 作者:David A. Boyd;S. Tongnunui;L. Page
- 通讯作者:David A. Boyd;S. Tongnunui;L. Page
Bioinspired Design in Research: Evolution as Beta-Testing
研究中的仿生设计:作为 Beta 测试的进化
- DOI:10.1093/icb/icac134
- 发表时间:2022
- 期刊:
- 影响因子:2.6
- 作者:Flammang, Brooke E.
- 通讯作者:Flammang, Brooke E.
Revision of the Genus Henicorhynchus, with a Revised Diagnosis of Gymnostomus (Cyprinidae: Labeoninae)
- DOI:10.1643/ci-19-304
- 发表时间:2020-08
- 期刊:
- 影响因子:2.6
- 作者:P. Ciccotto;L. Page
- 通讯作者:P. Ciccotto;L. Page
Garra surinbinnani, a new species of labeonine from the Mae Khlong basin of Thailand (Teleostei: Cyprinidae).
Garra surinbinnani,来自泰国 Mae Khlong 盆地的 Labeonine 新种(Teleostei:鲤科)。
- DOI:10.23788/ief-1117
- 发表时间:2019
- 期刊:
- 影响因子:1
- 作者:Page, L.;Ray, B. R.;Boyd, D. A.;Randall, Z. S.
- 通讯作者:Randall, Z. S.
They like to move it (move it): walking kinematics of balitorid loaches of Thailand
他们喜欢移动它(移动它):泰国巴里托里德泥鳅的行走运动学
- DOI:10.1242/jeb.242906
- 发表时间:2022
- 期刊:
- 影响因子:2.8
- 作者:Crawford, Callie H.;Webber-Schultz, Amani;Hart, Pamela B.;Randall, Zachary S.;Cerrato-Morales, Cristian;Kellogg, Audrey B.;Amplo, Haley E.;Suvarnaraksha, Apinun;Page, Lawrence M.;Chakrabarty, Prosanta
- 通讯作者:Chakrabarty, Prosanta
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Brooke Flammang其他文献
Brooke Flammang的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
RoL: FELS: EAGER Rules for cellular adaptation to the mechanical properties of their environment
RoL:FELS:细胞适应环境机械特性的 EAGER 规则
- 批准号:
2054796 - 财政年份:2020
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
RoL: FELS: RAISE: Rules That Govern Seasonal Migration of Birds Through the Air
RoL:FELS:RAISE:管理鸟类空中季节性迁徙的规则
- 批准号:
1840230 - 财政年份:2019
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
RoL: FELS Conference: A Fading Cryosphere Shifting Temperature and Stoichiometry in Mountain Lakes and Streams: A US-China Cooperative Workshop
RoL:FELS 会议:消失的冰冻圈改变高山湖泊和溪流的温度和化学计量:中美合作研讨会
- 批准号:
1834494 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
RoL: FELS: EAGER: Landscape Phenomics: Predicting vulnerability to climate variation by linking environmental heterogeneity to genetic and phenotypic variation
RoL:FELS:EAGER:景观表型组学:通过将环境异质性与遗传和表型变异联系起来预测气候变化的脆弱性
- 批准号:
1838282 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
RoL: FELS: EAGER: Mining for ancient toolkits: Emergence of planar structures across kingdoms
RoL:FELS:渴望:古代工具包的开采:各个王国平面结构的出现
- 批准号:
1838291 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
RoL: FELS: EAGER: Genetic Constraints on the Increase of Organismal Complexity Over Time
RoL:FELS:EAGER:随着时间的推移,生物体复杂性增加的遗传限制
- 批准号:
1838307 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
RoL: FELS: EAGER: Metabolic asymmetry: An energetic rule for linking biology across scales
RoL:FELS:EAGER:代谢不对称:跨尺度联系生物学的能量规则
- 批准号:
1838346 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
Collaborative Research: RoL: FELS: EAGER: Determining the Interplay of Long- and Short-Range Interactions in Emergent Biological Collective Behavior
合作研究:RoL:FELS:EAGER:确定新兴生物集体行为中长程和短程相互作用的相互作用
- 批准号:
1838341 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
RoL: FELS: EAGER: Collaborative Research: Exceptions that Test the Rules - Establishing the Feasibility of Avian Feather Muscles as a Study System for Neuromotor Control
RoL:FELS:EAGER:协作研究:测试规则的例外 - 建立鸟类羽毛肌肉作为神经运动控制研究系统的可行性
- 批准号:
1838688 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant
Collaborative Research: RoL: FELS: Workshop - Rules of Life in the Context of Future Mathematical Sciences
合作研究:RoL:FELS:研讨会 - 未来数学科学背景下的生命规则
- 批准号:
1839608 - 财政年份:2018
- 资助金额:
$ 99.75万 - 项目类别:
Standard Grant