CAREER: Wirelesss Sensing for In Vivo Medical Devices

职业：体内医疗设备的无线传感

• 批准号: 1844280
• 负责人: Fadel Adib
• 金额: $ 65.83万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1844280&HistoricalAwards=false
• 关键词: CAREER; Wirelesss; Sensing; Vivo; Medical

This project develops wireless networking systems for deep-tissue micro-implants. The micro-implants may be swallowed or injected into the human body and used for applications such as delivering drugs or monitoring internal human vitals. The challenge in building these systems arises from the power, size, and longevity constraints of micro-implants as well as the anatomical complexity of the human body and its interaction with wireless signals. By overcoming these challenges, this research will enable a new generation of networked micro-implants that can actively contribute to human health and well-being. The goal of this project is to design and build practical wireless systems that are capable of communicating with and localizing micro-implants at near-zero power. To this end, the researchers plan to augment micro-implants with backscatter sensors and develop algorithms, protocols, and system architectures for these sensors. The proposed research contributions encompass developing (i) algorithms for reliable and adaptive deep-tissue communication, (ii) techniques for accurate cross-medium backscatter localization, and (iii) integrated sensing platforms that combine communication, localization, and sensing on battery-free micro-implants. The proposed research will extend beyond the conception of algorithms and systems to the implementation and evaluation of real-world prototypes. The designs will be integrated on micro-implants with sensing and actuation capabilities, and will be evaluated in a number of applications such as wireless smart pills for targeted drug delivery and internal vital sign sensors for continuous in-vivo monitoring.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目开发用于深层组织微型植入物的无线网络系统。微植入物可以被吞咽或注射到人体中，并用于诸如递送药物或监测人体内部生命体征的应用。构建这些系统的挑战来自微型植入物的功率、尺寸和寿命限制，以及人体的解剖复杂性及其与无线信号的相互作用。通过克服这些挑战，这项研究将使新一代网络化微植入物能够积极促进人类健康和福祉。该项目的目标是设计和构建实用的无线系统，能够在接近零功率的情况下与微型植入物进行通信并定位。为此，研究人员计划用反向散射传感器增强微型植入物，并为这些传感器开发算法、协议和系统架构。拟议的研究贡献包括开发（i）可靠和自适应的深层组织通信算法，（ii）准确的跨介质反向散射定位技术，以及（iii）集成传感平台，结合联合收割机通信，定位和传感无电池微型植入物。拟议的研究将超越算法和系统的概念，以实现和评估现实世界的原型。这些设计将被集成到具有传感和驱动能力的微型植入物上，并将在许多应用中进行评估，例如用于靶向药物输送的无线智能药丸和用于连续体内监测的内部生命体征传感器。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

The Underwater Backscatter Channel: Theory, Link Budget, and Experimental Validation

水下反向散射通道：理论、链路预算和实验验证

• DOI: 10.1145/3570361.3613265
• 发表时间: 2023
• 期刊: ACM
• 作者: Akbar, Waleed;Allam, Ahmed;Adib, Fadel
• 通讯作者: Adib, Fadel

A Handheld Fine-Grained RFID Localization System with Complex-Controlled Polarization

• DOI: 10.1145/3570361.3592504
• 发表时间: 2023-02
• 期刊: Proceedings of the 29th Annual International Conference on Mobile Computing and Networking
• 作者: L. Dodds;I. Perper;A. Eid;Fadel M. Adib

Wireless, Batteryless, and Secure Implantable System-on-a-Chip for 1.37mmHg Strain Sensing with Bandwidth Reconfigurability for Cross-Tissue Adaptation

用于 1.37mmHg 应变传感的无线、无电池、安全植入片上系统，具有带宽可重构性，可实现跨组织适应

• DOI: 10.1109/cicc53496.2022.9772815
• 发表时间: 2022
• 期刊: 2022 IEEE Custom Integrated Circuits Conference (CICC
• 作者: Abdelhamid, M. R.;Ha, U.;Banerjee, U.;Adib, F.;Chandrakasan, A.
• 通讯作者: Chandrakasan, A.

Self-reconfigurable micro-implants for cross-tissue wireless and batteryless connectivity

• DOI: 10.1145/3372224.3419216
• 发表时间: 2020-09
• 期刊: Proceedings of the 26th Annual International Conference on Mobile Computing and Networking
• 作者: Mohamed R. Abdelhamid;Ruicong Chen;Joonhyuk Cho;A. Chandrakasan;Fadel M. Adib

Augmenting Augmented Reality with Non-Line-of-Sight Perception

• 发表时间: 2023
• 作者: Tara Boroushaki;Maisy Lam;L. Dodds;A. Eid;Fadel M. Adib