CAREER: Biomimetic 2-in-1 Sensor for Probing Mechanical and Electrical Cellular Responses Simultaneously

职业：用于同时探测机械和电细胞响应的仿生二合一传感器

• 批准号: 1844904
• 负责人: Jun Yao
• 金额: $ 50万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1844904&HistoricalAwards=false
• 关键词: CAREER; Biomimetic; Sensor; Probing; Mechanical

The cell is a basic functional element in biology, and as such the cellular state is ultimately connected to every aspect in human health and bodily function. The mechanical and electrical behaviors of a cell are two basic properties that indicate cell state, and consequently are important for health monitoring, disease diagnosis, and tissue repair. A comprehensive assessment of cellular status requires the knowledge of both mechanical and electrical properties at the same time, which remains challenging because the two properties are usually measured by different sensors, while the degree of cell perturbation increases with the number of sensors used. This project aims to develop a type of nanoscale (i.e., very small) sensor which can simultaneously measure both the mechanical and electrical properties in a cell. The convergence of both measurements in one sensor will provide (1) an automatic solution to the simultaneous measurement of both properties, and (2) a means of acquiring information without introducing additional cell perturbation. This sensor technology can lead to more precise biomedical devices for disease modeling, drug screening, and health diagnostics. The interdisciplinary research will also serve as a platform for outreach and broadening participation in STEM education.This project will investigate multiple sensing mechanisms in a nanostructured sensor to enable simultaneous mechanical- and electrical-signal couplings and transductions at the cell-sensor interface. The central approach is to borrow from structures in multifunctional biological sensory organelles to engineer a nanoscale sensor, which is expected to yield functional emulation for multi-parameter sensing. The concept of merging multiple sensing functions in one device will broaden the capabilities of general bio-interface engineering, yielding (1) a solution in synchronization and scalability for multiparameter measurements and (2) a ?2-in-1? economical integration approach important for minimizing invasiveness to biosystems. Eventually the biomimetic ?one-for-more? sensor concept will lead to efficient, parallel, and multi-thread cellular monitoring and communication. The developed sensor technology will also provide a new tool for fundamental studies in cell mechanics and electrophysiology. The research will also provide new insight on biomimetic approaches to building efficient interface to biosystemsThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

细胞是生物学中的基本功能元素，因此细胞状态最终与人类健康和身体功能的方方面面有关。细胞的机械和电学行为是指示细胞状态的两个基本属性，因此对于健康监测、疾病诊断和组织修复非常重要。对细胞状态的全面评估需要同时了解机械和电学性质，这仍然具有挑战性，因为这两种性质通常是由不同的传感器测量的，而细胞扰动的程度随着使用的传感器数量的增加而增加。该项目旨在开发一种纳米级(即非常小)的传感器，可以同时测量细胞中的机械和电学性质。两个测量在一个传感器中的融合将提供(1)同时测量这两个性质的自动解决方案，以及(2)在不引入额外细胞扰动的情况下获取信息的方法。这种传感器技术可以带来更精确的生物医学设备，用于疾病建模、药物筛选和健康诊断。跨学科研究还将作为扩大和扩大参与STEM教育的平台。该项目将研究纳米结构传感器中的多种传感机制，以实现细胞-传感器界面上的同时机械和电信号耦合和换能器。中心方法是借鉴多功能生物感官细胞器的结构来设计纳米级传感器，预计将产生多参数传感的功能仿真。在一个设备中融合多个传感功能的概念将扩展一般生物接口工程的能力，产生(1)多参数测量的同步和可扩展性解决方案和(2)2合1？经济的集成方法对于最大限度地减少对生物系统的入侵很重要。最终仿生？一对一？传感器的概念将导致高效、并行和多线程的细胞监测和通信。开发的传感器技术也将为细胞力学和电生理学的基础研究提供新的工具。这项研究还将为建立生物系统高效接口的仿生方法提供新的见解。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Generic Air‐Gen Effect in Nanoporous Materials for Sustainable Energy Harvesting from Air Humidity

纳米多孔材料中的通用空气-发电机效应，用于从空气湿度中可持续收集能量

• DOI: 10.1002/adma.202300748
• 发表时间: 2023
• 期刊: Advanced Materials
• 影响因子: 29.4
• 作者: Liu, Xiaomeng;Gao, Hongyan;Sun, Lu;Yao, Jun
• 通讯作者: Yao, Jun

Deterministic Assembly of Three-Dimensional Suspended Nanowire Structures

• DOI: 10.1021/acs.nanolett.9b02198
• 发表时间: 2019-08-01
• 期刊: NANO LETTERS
• 影响因子: 10.8
• 作者: Gao, Hongyan;Yin, Bing;Yao, Jun
• 通讯作者: Yao, Jun

Bioinspired bio-voltage memristors

• DOI: 10.1038/s41467-020-15759-y
• 发表时间: 2020-04-20
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Fu, Tianda;Liu, Xiaomeng;Yao, Jun
• 通讯作者: Yao, Jun

Multifunctional Protein Nanowire Humidity Sensors for Green Wearable Electronics

• DOI: 10.1002/aelm.202000721
• 发表时间: 2020-08-12
• 期刊: ADVANCED ELECTRONIC MATERIALS
• 影响因子: 6.2
• 作者: Liu, Xiaomeng;Fu, Tianda;Yao, Jun
• 通讯作者: Yao, Jun