CAREER: Engineering Tunable Fluorescent Organic Salts for Next Generation Imaging and Photodynamic Therapy

职业：为下一代成像和光动力治疗设计可调谐荧光有机盐

• 批准号: 1845006
• 负责人: Sophia Lunt
• 金额: $ 50万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1845006&HistoricalAwards=false
• 关键词: CAREER; Engineering; Tunable; Fluorescent; Organic

This project will use fluorescent organic salts to provide a new way for controlling photoexcited (i.e., activated by light) interactions at the cellular level. The principal investigator seeks to improve fluorescent dyes to limit toxicity for application to cell imaging and photodynamic therapy (PDT). The approach will develop a range of organic salts, assess phototoxicity (i.e., toxicity due to light) and then evaluate the chosen contrast agents. Improved imaging agents will be broadly useful and preliminary data suggest a reduction in phototoxicity. The research can lead to novel fluorescent probes for broad societal impact ranging from biomedicine and diagnostics to solar cells by enabling selective photodynamic therapy without side effects; brighter medical imaging that penetrate deeper into tissue for tumor detection and image-guided surgery.The principal investigator utilizes a new approach that will pair fluorescent ions with non-fluorescent counterions to independently modulate frontier molecular orbital levels proposed to be responsible for cyto- and photo-toxicity, without modifying optical properties. The principal investigator proposes that the fine-tuning concept can be applied to both novel and commercially available fluorescent probes and will enable precise toxicity modulation of fluorescent probes in eukaryotic cells for a range of applications. The principal investigator will systematically engineer a series of ions that tune optoelectronic properties of fluorescent organic salts by modulating the degree of halogenation, steric bulk, and dipole moments. The central hypothesis will test if fluorescent organic salts provide cytotoxic and phototoxic tunability through counterion coupling by generating resonant reactive oxygen species via charge injection in cellular environments.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

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项目成果

Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing

• DOI: 10.1038/s41598-019-51593-z
• 发表时间: 2019-10-25
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Broadwater, Deanna;Bates, Matthew;Lunt, Sophia Y.
• 通讯作者: Lunt, Sophia Y.

Enhanced Lifetime of Cyanine Salts in Dilute Matrix Luminescent Solar Concentrators via Counterion Tuning

• DOI: 10.1021/acsphotonics.3c00602
• 发表时间: 2023-08-23
• 期刊: ACS PHOTONICS
• 影响因子: 7
• 作者: Herrera，Christopher K.;Vahdani，Aria;Lunt，Richard R.
• 通讯作者: Lunt，Richard R.