Excellence in Research: The Visible Ape Project

卓越研究：可见猿项目

• 批准号: 1856329
• 负责人: Rui Diogo
• 金额: $ 48.46万
• 依托单位: Howard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1856329&HistoricalAwards=false
• 关键词: Excellence; Research; Visible; Ape; Project

One of the major questions in biology is how small genotypic differences can underpin striking phenotypic differences in anatomy, physiology, development, and behavior, like those seen between humans and apes. Indeed, we share nearly 99% of our DNA with chimpanzees, our closest living ape relatives, despite having substantially different appearances and behaviors. In order to study these genotype-phenotype relationships across humans and apes, detailed phenotypic data, including anatomical data, are needed. However, despite a fascination about apes that is shared by many scientists and the broader public, there are very limited resources for accessing and exploring ape anatomy. This project will develop a comprehensive, user-friendly and freely available resource on ape anatomy, the Visible Ape Project (VAP). This website and mobile/tablet app anatomical resource will be hosted at Howard University, to assure long-term availability and visibility of the data and support STEM research and scientific dissemination at a Historically Black University (HBCU). The VAP will serve as a valuable cross-disciplinary resource and create interdisciplinary connections between medical/veterinary education and biological anthropology. The VAP will also support public interest in science, drawing further attention to and awareness of apes, whose continued existence in the wild is seriously threatened. A number of outreach activities, including US and internationally-collaborative workshops, educational, and conservation activities, will reach the public, students from the high school level through graduate levels, and researchers and medical/veterinary practitioners. In the way that GenBank has been transformative for genetic research, the VAP is a major step towards transforming the 'phenome' in terms of providing a resource with comprehensive image data of ape anatomy directly comparable to human anatomy. In particular, the VAP and its comparisons with the Visible Human Project will allow researchers to address fundamental questions about the genomic, developmental, evolutionary and functional bases of human and ape anatomy and development, the origin and variations of the human body, and the features that make humans unique. Specifically, the VAP will include about 1,050 labeled images (dissection photographs, 3D photogrammetry, anatomical illustrations, CT/MRI scans) and 3D models of neonates and adults of each major ape group, as well as more than 250 labeled and 10,000 unlabeled full body and brain serial sections of both neonatal and adult chimps.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物学中的一个主要问题是，微小的基因型差异如何能够支撑解剖学、生理学、发育和行为方面的显著表型差异，就像在人类和猿类之间看到的那样。事实上，我们与黑猩猩有近99%的DNA是相同的，黑猩猩是我们最亲近的猿类亲戚，尽管它们的外表和行为有很大的不同。为了研究人类和猿类之间的这些基因型-表型关系，需要详细的表型数据，包括解剖数据。然而，尽管许多科学家和更广泛的公众都对猿着迷，但访问和探索猿解剖学的资源非常有限。该项目将开发一个全面的、用户友好的和免费提供的猿类解剖学资源，即可见猿项目（VAP）。该网站和移动的/平板电脑应用程序解剖资源将托管在霍华德大学，以确保数据的长期可用性和可见性，并支持STEM研究和历史上黑人大学（HBCU）的科学传播。VAP将作为一个宝贵的跨学科资源，并在医学/兽医教育和生物人类学之间建立跨学科的联系。VAP还将支持公众对科学的兴趣，进一步引起人们对猿类的关注和认识，猿类在野外的继续生存受到严重威胁。一些外展活动，包括美国和国际合作研讨会，教育和保护活动，将接触到公众，从高中到研究生水平的学生，以及研究人员和医疗/兽医从业人员。在基因库已经为遗传研究的变革的方式，VAP是一个重要的一步，朝着改变“表型”方面提供了一个资源与猿解剖学的全面图像数据直接可比的人类解剖学。特别是，VAP及其与可视人类项目的比较将使研究人员能够解决有关人类和猿解剖和发育的基因组，发育，进化和功能基础，人体的起源和变化以及使人类独特的特征的基本问题。具体而言，VAP将包括约1，050个标记图像（解剖照片，3D摄影测量，解剖插图，CT/MRI扫描）和每个主要猿类群体的新生儿和成年人的3D模型，以及250多个标记和10个，该奖项反映了NSF的法定使命，并被认为是值得的通过使用基金会的知识价值和更广泛的影响审查标准进行评估，

项目成果

The arteries of the musculoskeletal system of siamangs, and a comparison with other hylobatids, greater apes, and humans

合趾猿肌肉骨骼系统的动脉，以及与其他长臂猿、类人猿和人类的比较

• DOI: 10.1002/jmor.21480
• 发表时间: 2022
• 期刊: Journal of Morphology
• 影响因子: 1.5
• 作者: Cheung, Laraine H.;Martin, Jose S.;Barger, Nicole;Phillips, Carina;Fernandez, Vincent;Diogo, Rui
• 通讯作者: Diogo, Rui

The Visible Ape Project: A free, comprehensive, web‐based anatomical atlas for scientists and veterinarians designed to raise public awareness about apes

可见猿项目：为科学家和兽医提供免费、全面、基于网络的解剖图谱，旨在提高公众对猿的认识

• DOI: 10.1002/evan.21896
• 发表时间: 2021
• 期刊: and Reviews
• 作者: Barger, Nicole;Martín, José Saúl;Boyle, Eve K.;Richmond, Marli;Diogo, Rui
• 通讯作者: Diogo, Rui