Microbial Pathogens as Selective Agents in the Evolution of Arthropod Sociality

微生物病原体作为节肢动物社会性进化中的选择剂

• 批准号: DP0879229
• 负责人: Prof Andrew Beattie
• 金额: $ 17.35万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0879229
• 关键词: Microbial; Pathogens; Selective; Agents; Evolution

We will reveal ecological and evolutionary forces that have shaped a major response of social insects to microbial disease, then apply the results to drug discovery. We will generate the first data on a new approach to antibiotic bioprospecting in the social insects yielding two major outcomes: First, we identify novel sources of antimicrobial compounds. Second, we demonstrate that the new, biorational approach is a potent tool for natural product pharmaceutical bioprospecting. Both outcomes contribute directly to the National Research Priority Goal for the Sustainable Use of Australia's Biodiversity by developing new ways to find and identify novel natural resources.

我们将揭示生态和进化的力量，这些力量塑造了社会昆虫对微生物疾病的主要反应，然后将结果应用于药物发现。我们将产生第一个关于在群居昆虫中进行抗生素生物勘探的新方法的数据，产生两个主要结果：第一，我们确定了抗菌化合物的新来源。其次，我们证明了这种新的生物方法是天然产物药物生物勘探的有力工具。这两项成果通过开发寻找和识别新的自然资源的新方法，直接促进了可持续利用澳大利亚生物多样性的国家研究优先目标。