Excellence in Research: Collaborative Research on Nanosensors to Develop Research Capacities at Interdisciplinary Materials Research and Education Laboratory (IMREL)

卓越研究：纳米传感器合作研究，以发展跨学科材料研究和教育实验室（IMREL）的研究能力

• 批准号: 1900837
• 负责人: Zhiping Luo
• 金额: $ 50万
• 依托单位: Fayetteville State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1900837&HistoricalAwards=false
• 关键词: Excellence; Research; Collaborative; Nanosensors; Develop

This Excellence in Research (EIR) project, proposed by three investigators at Fayetteville State University (FSU), is to conduct interdisciplinary collaborative research on nanosensors including physical, chemical and biochemical sensors. A sensor is used to detect the changes in its environment, such as temperature, waves, electric/magnetic/electromagnetic fields, chemicals, etc., and a sensor made at the nanoscale may achieve higher sensitivities, extended detection limits, enhanced mechanical, physical and chemical properties, and high-throughput detection. This research includes three subprojects: (1) nanoscintillators for fast X-ray detection; (2) conjugated polymers and small molecules for optical sensing; and (3) highly sensitive electrochemical and fluorescent biochemical sensors based on oxide nanofibers for beta amyloid protein detection. The proposed research will be integrated with the education of undergraduates at FSU. FSU is a Historically Black University focusing on the education of African American students, with high female, military or military-affiliated student populations. This project carries with three project goals to: (1) build a strong collaborative research team for research in physical, chemical and biochemical sensors; (2) enhance infrastructure to support nanomaterials research; and (3) train the next generation of materials scientists and STEM (Science, Technology, Engineering and Mathematics) professionals in nanosensors research. The integration of research and education will improve the STEM educational quality of Materials Science minors from multiple STEM departments based on evidence-based practices, significantly enhancing the educational quality of undergraduates through the research-oriented education. Crosslinked with electronic structures and optical luminescence properties of nanomaterials, this EIR project will be conducted collaboratively: (1) research on physical sensors of nanoscintillators for fast X-ray detection will investigate factors controlling fast X-ray detection, and potentially identify new fast scintillator materials with optimized tunable emissions through chemical doping; (2) manipulation of optical properties of conjugated polymers and small molecules will provide important insights into how these systems can be applied as chemical sensors, and will provide directions for future design of cost-effective and highly sensitive solid-state chemical nanosensors using these materials; and (3) using oxide nanofiber scaffolds with high porosity and large surface areas, research on immunosensor will allow highly sensitive, selective, rapid and repeatable detection of beta amyloid. challenges of current enzyme sensors. The fast X-ray detection is highly desirable in a wide range of scientific time-resolved experiments to detect rapid pulsed radiations, such as the transient deformation or transformation process under extreme conditions in materials research. Optical sensing using conjugated polymer and small molecules will provide a simplified strategy for solid-state chemical sensing and is highly desirable to detect singlet oxygen, charge/ionic species and radicals. Immunosensors based on oxide nanofibers hold several promises for applications in biological, food, environmental and energy sciences. These advanced nanosensors will impact the hazard detection, disease detection, environmental monitoring, and exo-terrestrial monitoring.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项卓越研究（EIR）项目是由费耶特维尔州立大学（FSU）的三位研究人员提出的，旨在对纳米传感器进行跨学科的合作研究，包括物理、化学和生物化学传感器。传感器用于检测其所处环境的变化，如温度、波、电/磁/电磁场、化学物质等，而纳米级制造的传感器可以实现更高的灵敏度、更广的检测限、更强的机械、物理和化学性质，以及高通量检测。本研究包括三个子课题：(1)用于快速x射线探测的纳米闪烁体；(2)用于光学传感的共轭聚合物和小分子；(3)基于氧化物纳米纤维的高灵敏度电化学和荧光生化传感器，用于β -淀粉样蛋白检测。拟议的研究将与FSU的本科生教育相结合。佛罗里达州立大学是一所历史悠久的黑人大学，专注于非洲裔美国学生的教育，女性、军人或与军队有关的学生人数很多。本项目有三个项目目标：(1)建立一个强大的物理、化学和生化传感器研究的合作研究团队；(2)加强支持纳米材料研究的基础设施建设；(3)培养纳米传感器研究领域的下一代材料科学家和STEM（科学、技术、工程和数学）专业人员。研究与教育的整合将基于循证实践，提高材料科学专业多系未成年人的STEM教育质量，通过研究型教育显著提高本科生的教育质量。本项目将与纳米材料的电子结构和光学发光特性进行交联，合作进行：(1)用于快速x射线探测的纳米闪烁体物理传感器研究，研究控制快速x射线探测的因素，并有可能通过化学掺杂找到具有优化可调发射的新型快速闪烁体材料；(2)对共轭聚合物和小分子的光学性质的操纵将为这些系统如何应用于化学传感器提供重要的见解，并将为未来使用这些材料设计具有成本效益和高灵敏度的固态化学纳米传感器提供方向；(3)利用高孔隙率和大表面积的氧化纳米纤维支架，研究免疫传感器将实现高灵敏度、选择性、快速和可重复的β -淀粉样蛋白检测。当前酶传感器的挑战。在广泛的科学时间分辨实验中，快速x射线检测是非常需要的，以检测快速脉冲辐射，例如材料研究中极端条件下的瞬态变形或转化过程。使用共轭聚合物和小分子的光学传感将为固态化学传感提供一种简化的策略，并且非常适合检测单线态氧、电荷/离子种类和自由基。基于氧化物纳米纤维的免疫传感器在生物、食品、环境和能源科学等领域有着广阔的应用前景。这些先进的纳米传感器将影响危害检测、疾病检测、环境监测和地外监测。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Comparative study on material properties of wood-ash alkali and commercial alkali treated Sterculia fiber

• DOI: 10.1007/s10570-022-04610-w
• 发表时间: 2022-05-23
• 期刊: CELLULOSE
• 影响因子: 5.7
• 作者: Kandel, Krishna Prasad;Adhikari, Menuka;Neupane, Bhanu Bhakta
• 通讯作者: Neupane, Bhanu Bhakta

Electrospun porous La–Sr–Co–Ni–O nanofibers for highly sensitive non-enzymatic glucose detection

电纺多孔La-Sr-Co-Ni-O纳米纤维用于高灵敏非酶葡萄糖检测

• DOI: 10.1039/d1ma00984b
• 发表时间: 2022
• 期刊: Materials Advances
• 影响因子: 5
• 作者: Pelucarte, Kasci D.;Hatchell, Tashi A.;George, Gibin;Ede, Sivasankara Rao;Adhikari, Menuka;Lin, Yulin;Wen, Jianguo;Luo, Zhiping;Han, Shubo
• 通讯作者: Han, Shubo

Characterization of Electrospun ZnCr 2 O 4 Spinel Nanofibers

电纺ZnCr 2 O 4 尖晶石纳米纤维的表征

• DOI: 10.1017/s1431927622010066
• 发表时间: 2022
• 期刊: Microscopy and Microanalysis
• 影响因子: 2.8
• 作者: Adhikari, Menuka;Moore, Tamela L.;Morris, Zamari T.;Han, Shubo;Luo, Zhiping
• 通讯作者: Luo, Zhiping

Morphological and Compositional Characterization of Electrochemically Active Perovskite Oxides for Sensing Biological Molecules

用于传感生物分子的电化学活性钙钛矿氧化物的形态和成分表征

• DOI: 10.1017/s1431927620022369
• 发表时间: 2020
• 期刊: Microscopy and Microanalysis
• 影响因子: 2.8
• 作者: Hatchell, Tashi;Hutchenson, Kasci;George, Gibin;Luo, Zhiping;Han, Shubo
• 通讯作者: Han, Shubo

Novel Gelatin-based Bioplastic Materials Designed to Replace Polystyrene and Polypropylene in Single-use Hard Plastics

新型明胶基生物塑料材料旨在替代一次性硬塑料中的聚苯乙烯和聚丙烯

• DOI: 10.1017/s1431927622006377
• 发表时间: 2022
• 期刊: Microscopy and Microanalysis
• 影响因子: 2.8
• 作者: Zuravel, Kaitlyn;Zuravel, Lauren;Adhikari, Menuka;Luo, Zhiping;Gautam, Bhoj
• 通讯作者: Gautam, Bhoj