Engineering cyanine aggregation and self-assembly to access exceptionally red-shifted organic chromophores

设计花青聚集和自组装以获得异常红移的有机发色团

基本信息

批准号：
1905242
负责人：
Ellen Sletten
金额：
$ 52.05万
依托单位：
University of California-Los Angeles
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1905242&HistoricalAwards=false
关键词：
Engineering cyanine aggregation self assembly

项目摘要

In this project funded by the Macromolecular, Supramolecular, and Nanochemistry Program in the Division of Chemistry, Professors Ellen M. Sletten and Justin R. Caram of the Department of Chemistry at the University of California-Los Angeles are developing new fluorescent chemical compounds that re-emit light in the infrared region of the electromagnetic spectrum. Infrared waves are generally invisible to the human eye, but can be felt or detected as heat. Similar to x-rays, this light can penetrate through many objects, including skin and tissue. The compounds used in this research are very complex, yet easily made with unique properties that enable them to be highly colored. Additionally, they are several orders of magnitude brighter when assembled through molecular interactions in solution. The light intensity is particularly important for biomedical imaging applications such as early detection of cancer cells in human body. Additionally, the research is of relevance to the development of new and exciting devices in telecom-relevant optical fields in which information is communicated through long distances using infrared light. This work provides training and education to undergraduate and graduate students in synthetic organic chemistry and analytical characterization techniques. Several outreach activities are also developed that include educating the broader community about fluorescence and electromagnetic radiation. The research is an excellent avenue for engaging underrepresented minority and community college students in science.This research is focused on J-aggregates of cyanine fluorophores which emit in the shortwave infrared region of the electromagnetic spectrum (SWIR, 1000 to 2000 nm). To create SWIR J-aggregates, a systematic study of the factors that promote the self-assembly of chromophores into J-aggregates is conducted. Cyanine dyes are ideal complexes because they are easily synthetically accessible and are known to form J-aggregates with significant redshifts. In the first part of the project, four phenomena that are hypothesized to control J-aggregation (amphiphilicity, counterions, polymethine chain modification, and heterocycle polarizability) are explored through systematic chemical modifications and environmental control. In the second aim, these strategies are extended to a known SWIR cyanine dye. This research has the potential to generate transformative novel nanomaterials for applications in bioimaging and telecommunications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在该项目由化学系的大分子，超分子和纳米化学计划资助的项目中，加利福尼亚 - 洛杉矶分校化学系教授Ellen M. Sletten和Justin R. Caram正在开发新的荧光化合物，这些化合物重新发射了Electromagnetic Spectrum of Electromagneticspectrumsspectrum spectrum。红外波通常是人眼看不见的，但可以感觉到或被视为热量。与X射线相似，这种光可以穿透许多物体，包括皮肤和组织。这项研究中使用的化合物非常复杂，但很容易用独特的特性制成，从而使它们具有高色。此外，当通过溶液中的分子相互作用组装时，它们是几个数量级的亮度。光强度对于生物医学成像应用尤其重要，例如早期检测到人体中的癌细胞。此外，该研究与与电信相关的光场开发新颖而令人兴奋的设备的开发有关，其中使用红外光通过长距离传达信息。这项工作为合成有机化学和分析特征技术的本科生和研究生提供了培训和教育。还开发了一些外展活动，包括向更广泛的社区进行荧光和电磁辐射。这项研究是使代表性不足的少数群体和社区大学学生参与科学的绝佳途径。这项研究的重点是氰荧光团的J种群，这些氰胺荧光团在电磁频谱的短波红外区域（SWIR，1000至2000 nm）发出。为了创建SWIR J聚集物，对将发色团自组装成J聚集的因素进行了系统研究。氰胺染料是理想的复合物，因为它们很容易合成，并且已知会形成具有明显的红移的J-聚集物。在项目的第一部分中，通过系统的化学修饰和环境控制探索了四种用于控制J种群（两亲性，抗衡性，多叶肽链修饰和杂环极化）的现象。在第二个目标中，这些策略扩展到已知的Swir氰染料。这项研究有可能在生物成像和电信中生成变革性的新型纳米材料。该奖项反映了NSF的法定任务，并认为使用基金会的知识分子优点和更广泛的影响审查标准，认为值得通过评估来获得支持。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Thermodynamic Control over Molecular Aggregate Assembly Enables Tunable Excitonic Properties across the Visible and Near-Infrared

DOI：
10.1021/acs.jpclett.0c02204
发表时间：
2020-10-01
期刊：
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
影响因子：
5.7
作者：
Deshmukh, Arundhati P.;Bailey, Austin D.;Caram, Justin R.
通讯作者：
Caram, Justin R.

Dielectric Screening Modulates Semiconductor Nanoplatelet Excitons

介电屏蔽调制半导体纳米片激子

DOI：
10.1021/acs.jpclett.1c00624
发表时间：
2021
期刊：
The Journal of Physical Chemistry Letters
影响因子：
0
作者：
Shin, Ashley J.;Hossain, Azmain A.;Tenney, Stephanie M.;Tan, Xuanheng;Tan, Lauren A.;Foley, Jonathan J.;Atallah, Timothy L.;Caram, Justin R.
通讯作者：
Caram, Justin R.

Bridging the gap between H- and J-aggregates: Classification and supramolecular tunability for excitonic band structures in two-dimensional molecular aggregates

DOI：
10.1063/5.0094451
发表时间：
2022-06-01
期刊：
CHEMICAL PHYSICS REVIEWS
影响因子：
0
作者：
Deshmukh, Arundhati P.;Geue, Niklas;Caram, Justin R.
通讯作者：
Caram, Justin R.

Exploring the design of superradiant J-aggregates from amphiphilic monomer units

DOI：
10.1039/d2nr05747f
发表时间：
2023-01-27
期刊：
NANOSCALE
影响因子：
6.7
作者：
Bailey, Austin D.;Deshmukh, Arundhati P.;Caram, Justin R.
通讯作者：
Caram, Justin R.

Mercury Chalcogenide Nanoplatelet–Quantum Dot Heterostructures as a New Class of Continuously Tunable Bright Shortwave Infrared Emitters

汞硫族化物纳米片——量子点异质结构作为新型连续可调明亮短波红外发射器

DOI：
10.1021/acs.jpclett.0c00958
发表时间：
2020
期刊：
The Journal of Physical Chemistry Letters
影响因子：
0
作者：
Tenney, Stephanie M.;Vilchez, Victoria;Sonnleitner, Mikayla L.;Huang, Chengye;Friedman, Hannah C.;Shin, Ashley J.;Atallah, Timothy L.;Deshmukh, Arundhati P.;Ithurria, Sandrine;Caram, Justin R.
通讯作者：
Caram, Justin R.