权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

INJECTABLE, TUNABLE THERAPEUTIC IMPLANT TO REDUCE VOCAL FOLD SCAR

可注射、可调节的治疗植入物可减少声带疤痕

基本信息

批准号：
10647198
负责人：
Gregory Robert Dion
金额：
$ 24.11万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10647198
关键词：
Ablation Absorbable Implants Address Adjuvant Adjuvant Therapy Adrenal Cortex Hormones Affect Benign Biological Products Biomechanics Cell Therapy Cicatrix Clinical Communication impairment Data Development Dexamethasone Dose Drug Delivery Systems Drug Implants Dyes Dysphonia Effectiveness Encapsulated Extravasation Eye Fibrosis Fluorescence Foundations Functional disorder Glucocorticoids Goals Growth Health Care Costs Histologic Histology Immune response Implant Inflammation Inflammatory Injectable Injections Injury Intervention Intralesional Injections Larynx Lasers Lesion Light Measures Mechanics Modeling Mucous Membrane Operative Surgical Procedures Oral Outcome Patients Persons Pharmaceutical Preparations Phonation Postoperative Period Pre-Clinical Model Procedures Property Provider Publishing Quality of life Repeat Surgery Research Small Interfering RNA Speed Structure Submucosa System Techniques Technology Testing Therapeutic Time Tissues Trauma Treatment Cost Treatment Efficacy Voice Voice Disorders Wages Work biodegradable polymer capsule clinically relevant cost cyanine dye 5 design digital imaging drug release kinetics effective therapy healing immunoreaction implant design implant material improved in vivo injured innovation kinetic model nanoparticle novel novel therapeutics predictive modeling repaired response side effect treatment optimization vibration vocal cord wound healing

项目摘要

Project Summary Vocal fold scarring results in voice dysfunction and decreased quality of life for patients. With around 20 million people impacted by voice disorders each year, and vocal fold scar a common cause of this dysphonia with few effective treatments available, new, novel treatment approaches are needed. Currently, one of the primary challenges to treatment is wound healing optimization in the dynamic, delicate vocal fold multi-layer structure. Although surgical repair can be employed for vocal fold scar treatment, current surgical techniques often result in subsequent scarring. Adjuvant local therapeutic delivery, most commonly with corticosteroids, is often used to improve wound healing; however, limited access to the vocal folds generally restricts providers to a single therapeutic injection at the time of surgery. In-office procedures exist for subsequent therapeutic vocal fold injections, though these are uncomfortable for patients and increase treatment costs. Oral corticosteroids are not an effective alternative, as research has found them less effective than local application and with more side effects. Additional novel biologics have been proposed for vocal fold scar treatment, though these are also limited by similar delivery problems to corticosteroids. We have found that a novel, injectable encapsulated implant can deliver corticosteroids over time either in a sustained release fashion or in a laser-light activated approach effectively for up to eight months in a leporine eye preclinical model. In prior work, we found minimal immune response or unanticipated drug leakage from the injectable implant in the leporine eye. In parallel, we have optimized vocal fold biomechanical quantification matched to histology after vocal fold injuries. In the first aim, we will optimize our injectable implant for the vocal folds and measure any local immune response in healthy leporine vocal folds. In the second aim, we will employ the implant in a vocal fold injury model to quantify its healing impacts compared to no treatment or traditional single corticosteroid injections. This work lays the foundation for optimized, dose controllable therapeutic delivery to the vocal folds and improved drug delivery.

项目总结