INJECTABLE, TUNABLE THERAPEUTIC IMPLANT TO REDUCE VOCAL FOLD SCAR
可注射、可调节的治疗植入物可减少声带疤痕
基本信息
- 批准号:10647198
- 负责人:
- 金额:$ 24.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AblationAbsorbable ImplantsAddressAdjuvantAdjuvant TherapyAdrenal Cortex HormonesAffectBenignBiological ProductsBiomechanicsCell TherapyCicatrixClinicalCommunication impairmentDataDevelopmentDexamethasoneDoseDrug Delivery SystemsDrug ImplantsDyesDysphoniaEffectivenessEncapsulatedExtravasationEyeFibrosisFluorescenceFoundationsFunctional disorderGlucocorticoidsGoalsGrowthHealth Care CostsHistologicHistologyImmune responseImplantInflammationInflammatoryInjectableInjectionsInjuryInterventionIntralesional InjectionsLarynxLasersLesionLightMeasuresMechanicsModelingMucous MembraneOperative Surgical ProceduresOralOutcomePatientsPersonsPharmaceutical PreparationsPhonationPostoperative PeriodPre-Clinical ModelProceduresPropertyProviderPublishingQuality of lifeRepeat SurgeryResearchSmall Interfering RNASpeedStructureSubmucosaSystemTechniquesTechnologyTestingTherapeuticTimeTissuesTraumaTreatment CostTreatment EfficacyVoiceVoice DisordersWagesWorkbiodegradable polymercapsuleclinically relevantcostcyanine dye 5designdigital imagingdrug release kineticseffective therapyhealingimmunoreactionimplant designimplant materialimprovedin vivoinjuredinnovationkinetic modelnanoparticlenovelnovel therapeuticspredictive modelingrepairedresponseside effecttreatment optimizationvibrationvocal cordwound healing
项目摘要
Project Summary
Vocal fold scarring results in voice dysfunction and decreased quality of life for patients. With
around 20 million people impacted by voice disorders each year, and vocal fold scar a common
cause of this dysphonia with few effective treatments available, new, novel treatment
approaches are needed. Currently, one of the primary challenges to treatment is wound healing
optimization in the dynamic, delicate vocal fold multi-layer structure. Although surgical repair
can be employed for vocal fold scar treatment, current surgical techniques often result in
subsequent scarring. Adjuvant local therapeutic delivery, most commonly with corticosteroids, is
often used to improve wound healing; however, limited access to the vocal folds generally
restricts providers to a single therapeutic injection at the time of surgery. In-office procedures
exist for subsequent therapeutic vocal fold injections, though these are uncomfortable for
patients and increase treatment costs. Oral corticosteroids are not an effective alternative, as
research has found them less effective than local application and with more side effects.
Additional novel biologics have been proposed for vocal fold scar treatment, though these are
also limited by similar delivery problems to corticosteroids. We have found that a novel,
injectable encapsulated implant can deliver corticosteroids over time either in a sustained
release fashion or in a laser-light activated approach effectively for up to eight months in a
leporine eye preclinical model. In prior work, we found minimal immune response or
unanticipated drug leakage from the injectable implant in the leporine eye. In parallel, we have
optimized vocal fold biomechanical quantification matched to histology after vocal fold injuries.
In the first aim, we will optimize our injectable implant for the vocal folds and measure any local
immune response in healthy leporine vocal folds. In the second aim, we will employ the implant
in a vocal fold injury model to quantify its healing impacts compared to no treatment or
traditional single corticosteroid injections. This work lays the foundation for optimized, dose
controllable therapeutic delivery to the vocal folds and improved drug delivery.
项目总结
项目成果
期刊论文数量(0)
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