I-Corps Teams: Development of Noninvasive Diabetes Breath Sensors

I-Corps项目的更广泛影响/商业潜力是实现一种无创、简单和便携式的人体呼吸血糖水平监测。该项目将为研究生提供商业化培训，增强学生对商业化技能的学习。作为潜在的社会影响，这项创新将提高生活质量，通过使用无创呼吸传感器来识别糖尿病患者的人体血糖水平。新发现将通过演讲、研讨会、伙伴关系和向初创公司转让潜在技术的方式传播。来自不同公司的工业合作者将帮助将这一创新转化为工程实践。在采访过程中，将有100多人了解非侵入性糖尿病传感器的创新。I-Corps的这个项目是为了将一种无创呼吸生物传感器商业化进行市场分析和客户访谈，该传感器用于检测呼出气体中的丙酮，以识别人体血糖水平。分子印迹层通过允许特定分子暴露在传感器中，提高了传感器的选择性。丙酮印迹传感器在灵敏度约为15 &amp；#8486；/ppm时，与丙酮浓度在0- 10ppm范围内的增长表现出广泛的线性关系。与市场上现有的糖尿病传感器相比，该传感器具有以下优点。该传感器对丙酮的线性气体响应范围为0.9 ppm至10 ppm，可准确检测糖尿病患者呼吸中的丙酮浓度（通常在1.7 ppm至3.7 ppm范围内）。该传感器对来自不同气体分子（如水分、乙醇等）的丙酮具有高稳定性、高选择性和高灵敏度。这种传感器的尺寸很小，可以放进口袋里。糖尿病患者可以方便、分散地携带传感器，实时检测呼出气体中的丙酮，识别人体血糖水平，帮助判断患者的血糖水平。胰岛素需求。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project to enable a non-invasive, simple and portable monitoring blood glucose levels from human breath. This project will provide the commercialization training to graduate students and enhance students learning on commercialization skills. As a potential societal impact, this innovation will enhance the quality of life, by using noninvasive breath sensors for the recognition of human blood glucose level for diabetics. New discoveries will be disseminated through presentations, workshops, partnerships, and potential technology transfer to a start-up company. Industrial collaborators from various companies will help translate this innovation into engineering practice. More than 100 people will be outreached about the innovations in the noninvasive diabetes sensors during the interview process.This I-Corps project is to conduct market analysis and customer interviews for commercializing a noninvasive breath biosensor for detecting acetone in exhaled breath for the recognition of human blood glucose level. The molecular imprinted layer improved the selectivity of the sensors by allowing the specific molecule to be exposed into the sensor. The acetone-imprinted sensor shows a wide range of linear relationship with the growth of the acetone concentrations in the range of 0-10 ppm at a sensitivity about 15 Ω/ppm. This sensor has the following advantages over the existing diabetes sensors in the market. This sensor has a linear gas response to acetone from 0.9 ppm to 10 ppm, which leads to accurate detection of acetone concentration in breath of patients with diabetes (usually in the range of 1.7 ppm to 3.7 ppm). This sensor demonstrates high stability, improved selectivity, and high sensitivity for acetone from different gas molecules such as moisture, ethanol, etc. This sensor has a small size that can fit in a pocket. Patients with diabetes can conveniently and discretely carry the sensor for real-time detection of acetone in exhaled breath to recognize human blood glucose level and help determine a patient?s insulin needs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.