Collaborative Proposal: Testing mechanisms and consequences of W chromosome turnover in a dynamic plant system

合作提案:测试动态植物系统中 W 染色体更新的机制和后果

基本信息

  • 批准号:
    1912180
  • 负责人:
  • 金额:
    $ 79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-01 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

This research will test theories of the evolution of the genes and chromosomes that determine whether individuals are male or female. The project will identify processes that lead to changes in the chromosomal location of sex-determining genes in wild ancestors of the cultivated strawberry. The work will advance our knowledge of how these changes affect gene function and whole-plant growth and reproduction. Understanding how genes are arranged on chromosomes will expanding our knowledge of the effects of varied gene location on flower and fruit development, and will inform agricultural practices that ensure food security. Educational and outreach activities will bring knowledge gained by this research to the general public, and contribute to curriculum development for middle school and high school students.Genetic determination of sex is widespread across eukaryotes and the evolutionary dynamics can transcend wide taxonomic boundaries. Changes in either the chromosome pair that determines sex or the location of the sex-determining genes can be an important driver of phenotypic dimorphism, adaptive variation, and speciation. The research will test four leading hypothesized mechanisms for, and phenotypic consequences of, turnover in the W chromosome. The work will leverage the octoploid wild strawberry (Fragaria) where translocation-based turnover has been observed, enabling tests of predicted patterns of genomic fingerprints (changes in linkage disequilibrium and function polymorphisms) characteristic of each turnover mechanism. The work will use a combination of high-throughput sequencing, molecular evolutionary analysis, genetic linkage mapping, transcriptomics, and phenotypic assessment. The research will provide insight into a key dynamic of chromosomal evolution and shed light on a genomic restructuring mechanism that also underlies the evolution of other supergenes affecting complex phenotypes, adaptation, and speciation. The work will contribute to society by expanding knowledge of the effects of chromosomal rearrangement on ecological tolerances in important wild relatives of the cultivated strawberry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这项研究将测试决定个体是男性还是女性的基因和染色体进化的理论。该项目将确定导致栽培草莓野生祖先性别决定基因染色体位置变化的过程。这项工作将促进我们对这些变化如何影响基因功能以及整个植物的生长和繁殖的了解。了解基因在染色体上的排列方式将扩大我们对不同基因位置对花和果实发育影响的知识,并将为确保粮食安全的农业实践提供信息。教育和推广活动将把这项研究获得的知识带给普通公众,并为初中生和高中生的课程开发做出贡献。性别的遗传决定在真核生物中广泛存在,进化动态可以超越广泛的分类学边界。决定性别的染色体对或性别决定基因的位置的变化都可能是表型二态、适应性变异和物种形成的重要驱动因素。这项研究将测试W染色体转换的四个主要假设机制及其表型后果。这项工作将利用八倍体野生草莓(Fragaria),在那里观察到基于易位的周转,从而能够测试每种周转机制的基因组指纹预测模式(连锁不平衡和功能多态的变化)。这项工作将结合高通量测序、分子进化分析、遗传连锁图谱、转录组学和表型评估。这项研究将提供对染色体进化的关键动力的洞察,并揭示基因组重组机制,该机制也是影响复杂表型、适应和物种形成的其他超基因进化的基础。这项工作将通过扩大关于染色体重排对栽培草莓重要野生近缘的生态耐受性的影响的知识来为社会做出贡献。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Tia-Lynn Ashman其他文献

Correction: Floral traits and density are uneven drivers of heterospecific pollen deposition in a biodiverse tropical highland community
  • DOI:
    10.1007/s00442-025-05738-9
  • 发表时间:
    2025-06-18
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Nathália Susin Streher;Pedro Joaquim Bergamo;Tia-Lynn Ashman;Marina Wolowski;Marlies Sazima
  • 通讯作者:
    Marlies Sazima
A study of páramo plant-pollinator interactions on the sky islands of Colombia: specialization, modularity, and species roles
  • DOI:
    10.1007/s00035-024-00324-w
  • 发表时间:
    2025-01-03
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Laura Milena Manrique-Garzón;Tia-Lynn Ashman;Emilio Realpe;Eloisa Lasso
  • 通讯作者:
    Eloisa Lasso
Variation in nickel accumulation in leaves, reproductive organs and floral rewards in two hyperaccumulating Brassicaceae species
  • DOI:
    10.1007/s11104-014-2184-8
  • 发表时间:
    2014-07-01
  • 期刊:
  • 影响因子:
    4.100
  • 作者:
    George A. Meindl;Daniel J. Bain;Tia-Lynn Ashman
  • 通讯作者:
    Tia-Lynn Ashman
Global meta-analysis shows that threatened flowering plants have higher pollination deficits
全球荟萃分析表明,受威胁的开花植物具有更高的授粉赤字。
  • DOI:
    10.1038/s41467-025-61032-5
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Hanyang Lin;Yongge Yuan;Junmin Li;Joanne M. Bennett;Tia-Lynn Ashman;Gerardo Arceo-Gomez;Martin Burd;Laura A. Burkle;Jean H. Burns;Walter Durka;Allan G. Ellis;Leandro Freitas;James G. Rodger;Jana C. Vamosi;Marina Wolowski;Jing Xia;Tiffany M. Knight
  • 通讯作者:
    Tiffany M. Knight
Revisiting the origin of octoploid strawberry
重新审视八倍体草莓的起源
  • DOI:
    10.1038/s41588-019-0543-3
  • 发表时间:
    2019-12-16
  • 期刊:
  • 影响因子:
    29.000
  • 作者:
    Aaron Liston;Na Wei;Jacob A. Tennessen;Junmin Li;Ming Dong;Tia-Lynn Ashman
  • 通讯作者:
    Tia-Lynn Ashman

Tia-Lynn Ashman的其他文献

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{{ truncateString('Tia-Lynn Ashman', 18)}}的其他基金

NSFDEB-BSF: Building a broad understanding of the effect of polyploidy on the pollination niche and its cascading effects on plant-pollinator communities
NSFDEB-BSF:建立对多倍体对授粉生态位的影响及其对植物授粉媒介群落的级联效应的广泛理解
  • 批准号:
    2027604
  • 财政年份:
    2020
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant
Collaborative Research: SG: Exploring the effects of UV light on floral pigmentation
合作研究:SG:探索紫外线对花卉色素沉着的影响
  • 批准号:
    1753689
  • 财政年份:
    2018
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant
Collaborative Research: RAPID: Capturing initial eco-evolutionary dynamics of a novel chemical invader
合作研究:RAPID:捕捉新型化学入侵者的初始生态进化动态
  • 批准号:
    1834496
  • 财政年份:
    2018
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant
The role of post-pollination interactions in structuring co-flowering plant communities
授粉后相互作用在构建共花植物群落中的作用
  • 批准号:
    1452386
  • 财政年份:
    2015
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Testing long-standing adaptive hypotheses for floral traits in the UV spectrum using comparative methods
论文研究:使用比较方法测试紫外线光谱中花卉性状的长期适应性假设
  • 批准号:
    1309450
  • 财政年份:
    2013
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant
Dimensions US-China: Collaborative Research: An integrated understanding of how polyploidy generates biodiversity
维度 中美:合作研究:对多倍体如何产生生物多样性的综合理解
  • 批准号:
    1241006
  • 财政年份:
    2013
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant
Collaborative Research: Initiation of a sex-determining chromosome: insights from sexually dimorphic strawberries
合作研究:性别决定染色体的启动:来自两性草莓的见解
  • 批准号:
    1020523
  • 财政年份:
    2010
  • 资助金额:
    $ 79万
  • 项目类别:
    Continuing Grant
International Planning Grant: Pollination in a Biodiversity Hotspot
国际规划补助金:生物多样性热点地区的授粉
  • 批准号:
    0852846
  • 财政年份:
    2009
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant
Context-Dependent Mode of Selfing and Inbreeding Depression: Consequences for the Evolution of Dioecy
自交和近交衰退的环境依赖性模式:雌雄异体进化的后果
  • 批准号:
    0449488
  • 财政年份:
    2005
  • 资助金额:
    $ 79万
  • 项目类别:
    Continuing Grant
DISSERTATION RESEARCH: The Effect of Vegetative Herbivory on the Mating System and on the Demographic Value of Selfed and Outcrossed Progeny
论文研究:无性食草对交配系统以及自交和异交后代的人口统计学价值的影响
  • 批准号:
    0412120
  • 财政年份:
    2004
  • 资助金额:
    $ 79万
  • 项目类别:
    Standard Grant

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