CerS in colon cancer: Influence on T-cells and tumor environment (B05)

结肠癌中的 CerS：对 T 细胞和肿瘤环境的影响 (B05)

• 批准号: 238121018
• 金额: --
• 依托单位: Institut für Klinische Pharmakologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/238121018?language=en
• 关键词: CerS; colon; cancer; Influence; cells

Using human and mice primary T-cells, we want to investigate the role of CerS1, CerS3 and CerS5 on T-cell signaling, development and activity. Furthermore, the impact of these CerS on the communication between T-cells and colon cancer cells are investigated. In vivo, we ascertain the influence of CerS1, CerS3 and CerS5 in T-cells on the development of colitis and colitis associated carcinogenesis. At the end we want to bring together evidence, whether CerS1, CerS3 or CerS5 expression in T-cells are prognostic markers for T-cell activity under inflammatory condition or important for the anti-tumorigenic activity of T-cells.

使用人和小鼠的原代T细胞，我们想研究CerS1，CerS3和CerS5对T细胞信号传导，发育和活性的作用。此外，这些CerS对T细胞和结肠癌细胞之间的通信的影响进行了研究。在体内，我们确定CerS1，CerS3和CerS5在T细胞的结肠炎和结肠炎相关的致癌作用的发展的影响。最后，我们希望汇集证据，无论CerS1，CerS3或CerS5在T细胞中的表达是炎症条件下T细胞活性的预后标志物还是对T细胞的抗肿瘤活性很重要。