Pathology Core

病理学核心

• 批准号: 10709234
• 负责人: JINSONG LIU
• 金额: $ 22.6万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709234
• 关键词: Archives; Ascites; Award; Benign; Biopsy Specimen; Cancer Center; Clinical; Clinical Data; Code; Colon; Confidentiality of Patient Information; Consult; Cyst; Databases; Development; Diagnosis; Drug resistance; Endometrium; Evaluation; Experimental Designs; Feasibility Studies; Female Genital Neoplasms; Formalin; Freezing; Frozen Sections; Funding; Generations; Goals; Gynecologic; Human; Immunohistochemistry; In Situ Hybridization; Individual; Institution; Internet; Intranet; Laboratories; Laboratory Research; Link; Malignant neoplasm of ovary; Mammalian Oviducts; Microscopic; Modeling; Mucous Membrane; Mus; Normal tissue morphology; Organoids; Ovarian; Ovarian Diseases; Ovary; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Population Research; Process; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Sampling; Security; Services; Slide; Solid Neoplasm; Source; Specimen; Technology; Testing; Tissue Banks; Tissue Embedding; Tissue Microarray; Tissues; Tumor Bank; Tumor Tissue; University of Texas M D Anderson Cancer Center; biomarker identification; career; data access; endometriosis; experience; experimental study; novel therapeutics; patient derived xenograft model; quality assurance; tumor; virtual

Core C: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The research projects also need patient-derived xenograft models and organoids to test the effects of novel drugs and define the mechanisms of drug resistance. The proposed Pathology Core augments the already established MD Anderson Cancer Center Gynecological Tumor Bank and the P30- sponsored MD Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high- quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, histopathological expertise, tissue arrays, patient-derived xenografts, and organoids related to the specific needs of the research projects comprising this SPORE proposal. To meet this goal, the following Specific Aims are proposed for this Core. Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancers, normal ovaries, and benign ovarian processes (such as cysts and endometriosis). Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological and immunohistochemical technical services as necessary. Aim 3 is to create tissue microarrays, patient-derived xenografts (PDXs), and organoid models and maintain a relational SPORE Database. This SPORE Database will provide for a virtual tissue repository that can be shared electronically with all SPORE investigators.

核心C：病理摘要/摘要 包括这项卵巢癌孢子应用的个别研究项目需要采购， 卵巢癌和良性卵巢患者的组织病理学材料的加工和分析 疾病。研究项目需要冷冻和福尔马林固定，石蜡包裹的样品的样本 肿瘤和正常组织。研究项目还需要患者衍生的异种移植模型和器官 测试新药物的作用，并定义耐药性的机制。提出的病理核心 增强已经建立的MD Anderson癌症中心妇科肿瘤库和P30- 赞助的MD Anderson癌症中心集中组织存储库，并具有支持数据库和Intranet 使用权。核心为经验丰富的妇科病理学家的组织采集提供了组织，以确保高 研究人员参与该孢子的优质组织以及其他孢子的研究者。 病理核心的目的是提供冷冻的组织，石蜡包裹的组织，组织病理学 专业知识，组织阵列，患者衍生的异种移植物和类器官与研究的特定需求有关 包括此孢子提议的项目。为了实现这一目标，提出了以下特定目标 核。目标1是保持卵巢癌的冷冻和石蜡包裹的组织储存库，正常 卵巢和良性卵巢过程（例如囊肿和子宫内膜异位症）。目标2是提供病理 审查孢子项目中使用的所有临床标本，并提供组织病理学和 必要的免疫组织化学技术服务。 AIM 3是创建组织微阵列，患者来源 异种移植物（PDXS）和类器官模型并保持关系孢子数据库。这个孢子数据库 将提供一个虚拟组织存储库，该存储库可以与所有孢子研究人员进行电子方式共享。