Pathology Core

病理学核心

• 批准号: 10709234
• 负责人: JINSONG LIU
• 金额: $ 22.6万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709234
• 关键词: Archives; Ascites; Award; Benign; Biopsy Specimen; Cancer Center; Clinical; Clinical Data; Code; Colon; Confidentiality of Patient Information; Consult; Cyst; Databases; Development; Diagnosis; Drug resistance; Endometrium; Evaluation; Experimental Designs; Feasibility Studies; Female Genital Neoplasms; Formalin; Freezing; Frozen Sections; Funding; Generations; Goals; Gynecologic; Human; Immunohistochemistry; In Situ Hybridization; Individual; Institution; Internet; Intranet; Laboratories; Laboratory Research; Link; Malignant neoplasm of ovary; Mammalian Oviducts; Microscopic; Modeling; Mucous Membrane; Mus; Normal tissue morphology; Organoids; Ovarian; Ovarian Diseases; Ovary; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Population Research; Process; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Sampling; Security; Services; Slide; Solid Neoplasm; Source; Specimen; Technology; Testing; Tissue Banks; Tissue Embedding; Tissue Microarray; Tissues; Tumor Bank; Tumor Tissue; University of Texas M D Anderson Cancer Center; biomarker identification; career; data access; endometriosis; experience; experimental study; novel therapeutics; patient derived xenograft model; quality assurance; tumor; virtual

Core C: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The research projects also need patient-derived xenograft models and organoids to test the effects of novel drugs and define the mechanisms of drug resistance. The proposed Pathology Core augments the already established MD Anderson Cancer Center Gynecological Tumor Bank and the P30- sponsored MD Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high- quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, histopathological expertise, tissue arrays, patient-derived xenografts, and organoids related to the specific needs of the research projects comprising this SPORE proposal. To meet this goal, the following Specific Aims are proposed for this Core. Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancers, normal ovaries, and benign ovarian processes (such as cysts and endometriosis). Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological and immunohistochemical technical services as necessary. Aim 3 is to create tissue microarrays, patient-derived xenografts (PDXs), and organoid models and maintain a relational SPORE Database. This SPORE Database will provide for a virtual tissue repository that can be shared electronically with all SPORE investigators.

核心C：病理学摘要/摘要 包括卵巢癌孢子应用的个别研究项目需要采购， 卵巢癌和卵巢良性肿瘤患者组织病理学资料的处理和分析 疾病。研究项目需要冰冻和福尔马林固定的石蜡包埋样本 肿瘤和正常组织。研究项目还需要患者衍生的异种移植模型和有机化合物来 测试新药的效果并确定耐药机制。建议的病理学核心 扩大已经建立的MD Anderson癌症中心妇科肿瘤库和P30- 赞助MD Anderson癌症中心中央组织资料库及支援资料库及内联网 进入。核心提供由经验丰富的妇科病理学家进行组织采集，以确保高度的 为参与这一孢子的调查人员以及其他孢子的调查人员提供优质组织。 病理核心的目标是提供冰冻组织、石蜡包埋组织、组织病理学 与研究的特定需求相关的专业知识、组织阵列、患者来源的异种移植物和有机物 组成这个孢子提案的项目。为实现这一目标，提出了以下具体目标 核心。目标1是维护一个冷冻和石蜡包埋的卵巢癌组织信息库，正常 卵巢和良性卵巢突起(如囊肿和子宫内膜异位症)。目标2是提供病理性的 审查所有在孢子项目中使用的临床标本，并提供组织病理学和 必要时提供免疫组织化学技术服务。目标3是创建由患者衍生的组织微阵列 异种移植物(PDX)和器官模型，并维护一个相关的孢子数据库。这个孢子数据库 将提供一个虚拟组织储存库，可与所有孢子调查人员以电子方式共享。