MRI: Acquisition of an Advanced Microscopy System for the Multidisciplinary Research Track at Molloy College

MRI：为莫洛伊学院的多学科研究方向购买先进的显微镜系统

• 批准号: 1919583
• 负责人: Jodi Evans
• 金额: $ 19.06万
• 依托单位: MOLLOY UNIVERSITY
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919583&HistoricalAwards=false
• 关键词: MRI; Acquisition; Advanced; Microscopy; System

An award is made to Molloy College to acquire a microscopy system with time-lapse, Z-stack and multichannel acquisition capability. The instrument will be a vital part of several research projects investigating a broad cross section of topics including molecular genetics, immunology, molecular biology, cell cycle biology, cellular physiology and developmental biology. Biology students participate in these research projects as part of their education and training at Molloy. High school students are incorporated into the research groups through a high school internship program allowing for undergraduates to gain valuable mentoring experience. The high school students enter local, regional and national science competitions in line with Molloy's mission-directed goal of assisting high school districts in promoting a keen interest in science among their student body. In addition to research activities, the equipment will be incorporated into several courses in the Biology, Chemistry and Environmental Studies Department which will expose a majority of the biology and environmental studies majors as well as the biology education majors of the College to the many cutting-edge imaging techniques it supports. The use of this equipment in these research and training activities directly addresses the NSF goal of increasing the use of modern state-of-the-art research equipment by scientists and undergraduate students. The STEM initiatives currently in place at Molloy such as the New York State Collegiate Science and Technology Entry Program (CSTEP), ASPIRE to Careers in Science project funded through the NSF S-STEM mechanism and the NSF-sponsored Molloy College Noyce Ambassadors program will be strengthened. Students will receive advanced training in science that will ultimately make them more competitive for summer positions, research internships, civic engagement opportunities and careers in the biological sciences. The acquisition of this equipment will improve the efficiency and productivity of ongoing and planned research projects that will further understanding of 1) mesenchymal stem cell function during immune responses 2) maintenance of genomic stability in multicellular organisms 3) epigenetic mechanisms in neuron formation 4) cytoskeletal organization during microglial phagocytosis 5) hepatocyte triglyceride storage 6) yeast models of neurodegeneration and, 7) morphological and molecular dynamics of stem cell differentiation into normal vertebrate tissues during development. Results of these projects will be disseminated in peer-reviewed publications and through presentations at regional and national scientific meetings.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

莫洛伊学院获得了一个奖项，以获得一个具有延时，Z堆叠和多通道采集能力的显微镜系统。该仪器将是几个研究项目的重要组成部分，这些研究项目涉及广泛的主题，包括分子遗传学，免疫学，分子生物学，细胞周期生物学，细胞生理学和发育生物学。生物学学生参加这些研究项目作为他们在莫洛伊教育和培训的一部分。高中生通过高中实习计划被纳入研究小组，让本科生获得宝贵的指导经验。高中生参加地方，地区和国家科学比赛符合莫洛伊的使命为导向的目标，协助高中学区促进学生对科学的浓厚兴趣。除了研究活动，该设备将被纳入生物学，化学和环境研究系的几门课程，这将使大多数生物学和环境研究专业以及学院的生物教育专业的学生接触到它支持的许多尖端成像技术。在这些研究和培训活动中使用这种设备直接解决了NSF的目标，即增加科学家和本科生使用现代最先进的研究设备。目前在莫洛伊实施的STEM计划，如纽约州大学科学技术入学计划（CSTEP），通过NSF S-STEM机制资助的ASPIRE科学职业项目和NSF赞助的莫洛伊学院诺伊斯大使计划将得到加强。 学生将接受科学方面的高级培训，最终使他们在暑期职位，研究实习，公民参与机会和生物科学职业方面更具竞争力。该设备的购置将提高正在进行和计划中的研究项目的效率和生产力，这些项目将进一步了解1）免疫反应期间间充质干细胞的功能2）多细胞生物体中基因组稳定性的维持 3)神经元形成中的表观遗传机制4）小胶质细胞吞噬作用期间的细胞骨架组织5）肝细胞甘油三酯储存6）神经变性的酵母模型和7）发育期间干细胞分化成正常脊椎动物组织的形态学和分子动力学。这些项目的成果将在同行评审的出版物中传播，并通过在区域和国家科学会议上的演讲来传播。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

项目成果

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

间充质干细胞对巨噬细胞吞噬作用的调节；

• DOI: 10.3791/62729
• 发表时间: 2021
• 期刊: Journal of Visualized Experiments
• 作者: Evans, Jodi F.;Ricigliano, Anthony E.;Morante, Anthony V.;Martinez, Emily;Vargas, Darlisy;Thyagaraj, Jonah
• 通讯作者: Thyagaraj, Jonah