I-Corps: High Resolution Probes for Magnetic Resonance Imaging

I-Corps：用于磁共振成像的高分辨率探头

• 批准号: 1923066
• 负责人: Michael Lanagan
• 金额: $ 5万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1923066&HistoricalAwards=false
• 关键词: Corps; Resolution; Probes; Magnetic; Resonance

The broader impact/commercial potential of this I-Corps project is Magnetic Resonance Imaging (MRI) technology with enhanced spatial resolution and reduced scan time for investigating a comprehensive range of biological systems from single cells to humans. Novel MRI probes with dielectric pads will have an immediate impact on animal and human behavior studies where neuroscientists are using MRI techniques to monitor brain activity and cognition. Entirely new research and clinical tests become possible at increased resolution and reduced scan time. High-resolution MRI is a powerful tool for understanding metabolic activity in humans and animals. MRI will be a key diagnostic technique of the neuroscience - linking chemical and spatial information with neurological and brain disorders. In addition, researchers of Biological Anthropology, Fisheries and Biology will benefit from new tools with shorter MRI scan times and higher resolution. The I-Corps project will provide a commercial foundation for translating breakthroughs in high-resolution MRI probes to the life science and medical communities. This I-Corps project addresses fundamental electromagnetic challenges of high-resolution magnetic resonance imaging. Radio Frequency (RF) probes with dielectric pads have been successfully tested in a research setting for biological phantoms, animals and humans. The company will work with clinicians and researchers to translate the new RF probes into commercial and research-based MRI systems. The design flexibility of an RF probe with a dielectric pad provides for customized volumes of uniform magnetic field and allows for MRI of diverse samples including humans, mice, fish, and single cells. The proposed program will bring together material scientists, electrical engineers, biologists and radiologists to create a unique ecosystem for understanding the value of novel MRI RF probes in biological research and medicine. Integration of knowledge from different disciplines, combined with information from prospective users will assure the creation of a comprehensive plan for commercialization of RF probes in MRI scanners.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个i-Corps项目的更广泛的影响/商业潜力是磁共振成像(MRI)技术，它具有更高的空间分辨率和更短的扫描时间，可以研究从单细胞到人类的各种生物系统。带有电介质垫的新型MRI探针将对动物和人类行为研究产生立竿见影的影响，神经科学家正在使用MRI技术监测大脑活动和认知。在提高分辨率和减少扫描时间的情况下，全新的研究和临床测试成为可能。高分辨率核磁共振是了解人类和动物代谢活动的有力工具。核磁共振将成为神经科学的一项关键诊断技术--将化学和空间信息与神经和大脑疾病联系起来。此外，生物人类学、渔业和生物学的研究人员将受益于MRI扫描时间更短、分辨率更高的新工具。I-Corps项目将为将高分辨率核磁共振探头的突破转化为生命科学和医学界提供商业基础。这个i-Corps项目解决了高分辨率磁共振成像的基本电磁挑战。带有电介质垫的射频(RF)探头已在生物模体、动物和人类的研究环境中成功测试。该公司将与临床医生和研究人员合作，将新的射频探头转化为商业和基于研究的核磁共振系统。带有介质垫的RF探头的设计灵活性提供了定制的均匀磁场体积，并允许对包括人类、小鼠、鱼类和单细胞在内的各种样本进行磁共振成像。拟议的计划将把材料科学家、电气工程师、生物学家和放射学家聚集在一起，创建一个独特的生态系统，以了解新型磁共振射频探测器在生物研究和医学中的价值。整合来自不同学科的知识，结合来自潜在用户的信息，将确保创建一个全面的计划，使核磁共振扫描仪中的射频探头商业化。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。