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Collaborative research: Phylogenomic analyses of lorisiform primates using museum collections

合作研究：利用博物馆藏品对懒猴科灵长类动物进行系统基因组分析

基本信息

批准号：
1926215
负责人：
Mary Blair
金额：
$ 11.49万
依托单位：
American Museum Natural History
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1926215&HistoricalAwards=false
关键词：
Collaborative research Phylogenomic analyses lorisiform

项目摘要

This project will advance current understanding of the primate tree of life by investigating the evolutionary history of galagos and lorises, which are elusive, nocturnal primate species that have been understudied relative to other primate groups. The investigators will sequence the whole genomes of ten galago and loris genera for which no genomic data are yet available. They will also generate genomic data from a large number of primate specimens stored in museum collections. By combining these unprecedented datasets, this research will address fundamental questions about evolutionary relatedness, adaptations, and biogeography in these primate groups. The project will result in a freely accessible genomic database representing an important resource for future studies of all primates and especially for the galagos and lorises, which are extremely difficult to sample in the wild. This research and the database will also inform the conservation of galagos and lorises, many of which are highly endangered with extinction. The investigators will recruit graduate and undergraduate students from historically underrepresented groups in San Antonio (UTSA) and New York (AMNH), and train them in bioinformatics, molecular laboratory techniques, and conservation sciences. The investigators will also contribute to broader training through development of an open access teaching module on the applications of museum collections and phylogenomics to biodiversity conservation. Understanding primate evolutionary history and the processes of adaptation and diversification is a significant research goal within biological anthropology and biology. This task has been particularly difficult for small, nocturnal and elusive primate species like the galagos and lorises. This study will leverage the vast number of specimens housed in museum collections all over the world to improve our knowledge of the evolutionary history of the lorisiforms (galagos and lorises). By producing genomic data for this understudied group of primates, the investigators will be able to address questions about their evolutionary history, species diversity, and biogeography. The researchers will use a combination of short-read and long-molecule DNA sequencing to obtain genomic sequences of hundreds of specimens including all the known species currently recognized with the lorisiforms. This large comparative dataset will be used to 1) infer a comprehensive picture of the primate tree, including time estimates for the various branches; 2) identify cryptic species diversity; and 3) enable a stronger scientific basis to inform the conservation of endangered lorisiforms, which are typically neglected in both research focus and conservation attention in comparison to larger-bodied primates. This project is jointly funded by the Biological Anthropology program, Division of Behavioral and Cognitive Sciences, and the Systematics and Biodiversity Sciences Cluster, Division of Environmental Biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个项目将通过调查加拉戈斯和懒猴的进化历史来推进目前对灵长类生命树的理解，加拉戈斯和懒猴是难以捉摸的夜行灵长类物种，相对于其他灵长类动物群体，它们的研究还不够。研究人员将对10个盔猴和洛里斯属的全基因组进行测序，这些属目前还没有基因组数据。他们还将从博物馆收藏的大量灵长类动物标本中生成基因组数据。通过结合这些前所未有的数据集，这项研究将解决这些灵长类动物群体中有关进化相关性，适应性和生物学的基本问题。该项目将产生一个可免费访问的基因组数据库，为所有灵长类动物的未来研究提供重要资源，特别是对加拉戈斯和懒猴，这是非常难以在野外取样的。这项研究和数据库还将为加拉戈斯和懒猴的保护提供信息，其中许多物种濒临灭绝。研究人员将从圣安东尼奥（UTSA）和纽约（AMNH）历史上代表性不足的群体中招募研究生和本科生，并对他们进行生物信息学，分子实验室技术和保护科学方面的培训。调查人员还将通过开发一个关于博物馆收藏品和生物多样性基因组学应用于生物多样性保护的开放获取教学模块，为更广泛的培训做出贡献。了解灵长类动物的进化历史以及适应和多样化的过程是生物人类学和生物学的一个重要研究目标。这一任务对于像加拉戈斯和懒猴这样的小型、夜行性和难以捉摸的灵长类动物来说尤其困难。这项研究将利用世界各地博物馆收藏的大量标本，以提高我们对Lorisiforms（加拉戈斯和懒猴）进化历史的了解。通过为这一未被充分研究的灵长类动物群体提供基因组数据，研究人员将能够解决有关其进化历史，物种多样性和物种地理学的问题。研究人员将使用短读和长分子DNA测序的组合来获得数百个标本的基因组序列，包括目前已知的所有Lorisiforms物种。这个大型的比较数据集将用于1）推断灵长类动物树的全面图片，包括各种分支的时间估计; 2）识别神秘的物种多样性; 3）提供更强的科学依据，为濒危的Lorisiforms的保护提供信息，与体型较大的灵长类动物相比，它们通常在研究重点和保护关注方面都被忽视。该项目由行为与认知科学部的生物人类学项目和环境生物学部的系统学与生物多样性科学集群共同资助。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Adaptive evolution of Plasmodium-associated genes in primates

灵长类动物疟原虫相关基因的适应性进化

DOI：
发表时间：
2022
期刊：
American journal of biological anthropology
影响因子：
0
作者：
Tilton, KM;Trujillo, AE;Decamp, RM;Blair, ME;Pozzi, L;Disotell, TR;Tosi, AJ;Burrell, AS;Bergey, CM
通讯作者：
Bergey, CM

The impacts of mating system on sperm gene evolution in primates

交配系统对灵长类动物精子基因进化的影响

DOI：
发表时间：
2022
期刊：
American journal of biological anthropology
影响因子：
0
作者：
Decamp, RM;Trujillo, AE;Tilton, KM;Blair, ME;Pozzi, L;Disotell, TR;Tosi, AJ;Burrell, AS;Bergey, CM
通讯作者：
Bergey, CM

Unlocking the past: museomics of African galagids

揭开过去：非洲巨蜥的博物馆组学