权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

I-Corps: H-meter - point of care device for the analysis of hormones in blood

I-Corps：H-meter - 用于分析血液中激素的护理点设备

基本信息

批准号：
1929292
负责人：
Maria Fidalgo
金额：
$ 5万
依托单位：
University of Missouri-Columbia
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2022-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1929292&HistoricalAwards=false
关键词：
Corps meter point care device

项目摘要

The broader impact/commercial potential of this I-Corps project is the improvement of the quality of life of patients. Modern medicine relies heavily on the use of laboratory analysis to assess patient health, diagnose disease and monitor treatment efficacy. Many laboratory tests can be performed speedily at low cost, whereas other tests are expensive and take more time due to their need for skilled technicians and costly instruments. This project involves development of a rapid, low cost, point of care (POC) diagnostic system that can measure hormone levels with the sensitivity and specificity of clinical lab-based tests using only a single drop of blood. Currently, the high cost of laboratory-based hormonal tests is a barrier to their use in the diagnosis and treatment of hypogonadism in aging men and clinical management of gender non-conforming populations. An accurate and affordable hormone POC tests will allow more patients to receive optimal hormone therapy, reducing treatment side effects and improving patient quality of life. The proposed low cost, accurate, POC diagnostic system will improve the health care of rural populations, impoverished communities and third world countries. The proposed system also has veterinary applications that will improve animal health and the economics of the sector. This I-Corps project involves a technology that combined recent advances in nanotechnology, instrumentation, biology and medicine in a low cost, portable diagnostic test system that can accurately measure free testosterone at the point of care (POC) using blood collected from a finger prick. It will include a novel strip like sensor and a reading unit that can be interfaced with any smart phone/tablet. The sensor can selectively capture testosterone molecules from the blood sample and produce an optical signal proportional to the concentration present in the sample. As opposed to currently available technology, the sensor does not include antibodies in the recognition system, which results in longer shelf-time, lower cost and higher reliability. The reading unit will communicate via Bluetooth and/or WiFi interface, and interact with different mobile platforms; and include privacy-preserving features to address patient privacy concerns. The system will also provide information directly to the physician using encryption code and provide a support a telemedicine environment. The assessment feature of our product will lead to the improvement of doctor's diagnosis, which will result in an improvement on patient health. Proof-of-concept was demonstrated in 2018 and beta prototype will be complete by the end of summer 2019.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个i-Corps项目的更广泛的影响/商业潜力是改善患者的生活质量。现代医学在很大程度上依赖于使用实验室分析来评估患者的健康、诊断疾病和监测治疗效果。许多实验室测试可以以低成本快速进行，而其他测试则昂贵且需要更多时间，因为它们需要熟练的技术人员和昂贵的仪器。该项目涉及开发一种快速、低成本的护理点(POC)诊断系统，该系统可以仅使用一滴血液测量激素水平，具有基于临床实验室测试的灵敏度和特异度。目前，以实验室为基础的激素测试的高昂成本阻碍了它们在老年男性性腺功能低下症的诊断和治疗以及性别不一致人群的临床管理中的应用。准确和实惠的激素POC测试将使更多的患者接受最佳的激素治疗，减少治疗副作用，提高患者的生活质量。拟议的低成本、准确、POC诊断系统将改善农村人口、贫困社区和第三世界国家的医疗保健。拟议的系统还具有兽医应用，将改善动物健康和该部门的经济。这个i-Corps项目涉及一项技术，该技术将纳米技术、仪器、生物学和医学的最新进展结合在一种低成本、便携式诊断测试系统中，该系统可以使用从手指刺伤采集的血液准确地测量护理点(POC)的游离睾丸素。它将包括一个新颖的条状传感器和一个可以与任何智能手机/平板电脑接口的读取单元。该传感器可以选择性地从血液样本中捕获睾酮分子，并产生与样本中存在的浓度成比例的光学信号。与目前可用的技术不同，该传感器在识别系统中不包括抗体，这导致了更长的保质期、更低的成本和更高的可靠性。阅读器将通过蓝牙和/或WiFi接口进行通信，并与不同的移动平台交互；并包括隐私保护功能，以解决患者的隐私问题。该系统还将使用加密代码直接向医生提供信息，并为远程医疗环境提供支持。我们产品的评估功能将导致医生诊断的改善，从而改善患者的健康。概念验证已于2018年演示，测试版原型将于2019年夏末完成。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。