Gene-environment interactions in the etiology, symptomatology and treatment of Posttraumatic Stress Disorder

创伤后应激障碍的病因学、症状学和治疗中的基因-环境相互作用

• 批准号: 239855791
• 负责人: Professorin Dr. Iris-Tatjana Kolassa
• 金额: --
• 依托单位: Division of Cognitive Neuroscience
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/239855791?language=en
• 关键词: Gene; environment; interactions; etiology; symptomatology

Genetic risk factors contribute to the susceptibility of developing Posttraumatic Stress Disorder (PTSD) after exposure to traumatic events. A comprehensive characterization of the genetics of PTSD could contribute to a better understanding of the underlying molecular mechanisms and provide important insights for the development of pharmaceutics to prevent and treat PTSD (but eventually also other anxiety disorders). Furthermore, PTSD is uniquely suited for the study of gene × environment interactions since trauma exposure constitutes a necessary factor for the disorder to manifest. Likewise, in contrast to other disorders, the relevant environmental risk factor can be quantified and included in the analyses, which makes PTSD uniquely suited for etiological research on individual vulnerability factors. The recent development of cost-effective genotyping platforms allows high-resolution genome-wide association studies for the unbiased identification of novel genes related to PTSD. This project aims at systematically investigating the genetics of PTSD, by using genome-wide scans in a large sample of individuals from conflict regions in Africa. More specifically, we plan to investigate gene × environment interactions in the etiology and symptomatology of PTSD (Study A). The identified genetic risk factors will be validated in an independent sample (Study B) and their influence on the response to trauma-focused therapeutic treatment will be analyzed (Study C). The results of this project will contribute to a deeper understanding of genetic risk factors involved in PTSD etiology and their role in trauma-focused therapy.

遗传风险因素有助于创伤性事件暴露后发生创伤后应激障碍（PTSD）。对创伤后应激障碍遗传学的全面描述有助于更好地理解潜在的分子机制，并为预防和治疗创伤后应激障碍（最终也包括其他焦虑症）的药物开发提供重要见解。此外，创伤后应激障碍特别适合于基因与环境相互作用的研究，因为创伤暴露是该障碍表现的必要因素。同样，与其他疾病相比，相关的环境风险因素可以量化并纳入分析，这使得PTSD特别适合于个体易感因素的病因学研究。最近发展的具有成本效益的基因分型平台允许高分辨率全基因组关联研究，以公正地鉴定与创伤后应激障碍相关的新基因。该项目旨在通过对非洲冲突地区的大量个体样本进行全基因组扫描，系统地调查创伤后应激障碍的遗传学。更具体地说，我们计划研究PTSD病因学和症状学中基因与环境的相互作用（研究A）。确定的遗传风险因素将在独立样本中进行验证（研究B），并分析其对创伤性治疗反应的影响（研究C）。该项目的结果将有助于更深入地了解创伤后应激障碍病因的遗传风险因素及其在创伤治疗中的作用。

项目成果

Does trauma event type matter in the assessment of traumatic load?

• DOI: 10.1080/20008198.2017.1344079
• 发表时间: 2017
• 期刊: European journal of psychotraumatology
• 影响因子: 5
• 作者: Conrad D;Wilker S;Pfeiffer A;Lingenfelder B;Ebalu T;Lanzinger H;Elbert T;Kolassa IT;Kolassa S
• 通讯作者: Kolassa S

The downside of strong emotional memories: How human memory-related genes influence the risk for posttraumatic stress disorder – A selective review

强烈情绪记忆的缺点：人类记忆相关基因如何影响创伤后应激障碍的风险 – 选择性回顾

• DOI: 10.1016/j.nlm.2013.08.015
• 发表时间: 2014
• 期刊: Neurobiology of Learning and Memory
• 影响因子: 2.7
• 作者: Wilker;Elbert;Kolassa I.-T.
• 通讯作者: Kolassa I.-T.