权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

I-Corps: Multielectrode Array Biosensor

I-Corps：多电极阵列生物传感器

基本信息

批准号：
1936173
负责人：
Alexander Zestos
金额：
$ 5万
依托单位：
American University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2023-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1936173&HistoricalAwards=false
关键词：
Corps Multielectrode Array Biosensor

项目摘要

The broader impact/commercial potential of this I-Corps project ultimately will allow researchers to better understand the brain and improve the productivity of neurological studies. The societal impact of this invention will help researchers, scientists, and physicians alike make precise neurochemical measurements in the brain to better understand complex behaviors, diseases, and drug states. Carbon multielectrode arrays technology will enable measurements in the brain to better understand brain heterogeneity and neurological diseases that burden our society such as addiction/drug abuse, epilepsy, depression and anxiety. These multielectrode arrays will perform complex measurements of neurotransmitters in multiple brain regions simultaneously. The commercial potential for this novel technology is substantial in that, currently, there is no existing device that can simultaneously measure neurotransmission in multiple brain regions. These benefits should be of value to investigators, clinicians, and researchers in government, academic, and research institutions as well as industry.This I-Corps project will use carbon coated metal wires and carbon fibers as electrode materials to design, develop, and engineer multielectrode arrays. These multielectrode arrays will be used as electrode materials to detect neurotransmitters such as dopamine, serotonin, norepinephrine, and others in multiple brain regions simultaneously. This technology is cutting edge as no other neurological device has been developed with carbon fiber multielectrode arrays to be utilized as biosensors. This research will utilize fast scan cyclic voltammetry (FSCV) to detect neurotransmitters in preclinical models. A changing voltage will be applied to the electrode material to measure neurochemical changes in vivo in animal models. The technical results on which the project is based arise from laboratory experiments that have further developed these multielectrode arrays. The carbon fiber multielectrode arrays have been immersed in prepared neurotransmitter stock solutions in the laboratory and have successfully measured dopamine and other neurotransmitters using FSCV and data analysis software.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响/商业潜力最终将使研究人员更好地了解大脑并提高神经学研究的生产力。这项发明的社会影响将帮助研究人员、科学家和医生等在大脑中进行精确的神经化学测量，以更好地了解复杂的行为、疾病和药物状态。碳多电极阵列技术将使大脑测量能够更好地了解大脑异质性和给我们社会带来负担的神经系统疾病，如成瘾/药物滥用、癫痫、抑郁和焦虑。这些多电极阵列将同时对多个大脑区域的神经递质进行复杂的测量。这项新技术的商业潜力是巨大的，因为目前还没有可以同时测量多个大脑区域神经传递的现有设备。这些好处应该是有价值的调查人员，临床医生和研究人员在政府，学术界和研究机构以及industry.This I-Corps项目将使用碳涂层金属线和碳纤维作为电极材料的设计，开发和工程多电极阵列。这些多电极阵列将被用作电极材料，以同时检测多个大脑区域中的神经递质，如多巴胺，血清素，去甲肾上腺素等。这项技术是最先进的，因为没有其他神经系统设备已经开发出碳纤维多电极阵列，可用作生物传感器。本研究将利用快速扫描循环伏安法（FSCV）检测临床前模型中的神经递质。将对电极材料施加变化的电压，以测量动物模型中的体内神经化学变化。该项目所依据的技术成果来自进一步开发这些多电极阵列的实验室实验。碳纤维多电极阵列已经在实验室中浸泡在准备好的神经递质储备溶液中，并使用FSCV和数据分析软件成功地测量了多巴胺和其他神经递质。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Timed Electrodeposition of PEDOT:Nafion onto Carbon Fiber-Microelectrodes Enhances Dopamine Detection in Zebrafish Retina

DOI：
10.1149/1945-7111/aba33d
发表时间：
2020-01-08
期刊：
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
影响因子：
3.9
作者：
Cho, Whirang;Liu, Favian;Zestos, Alexander G.
通讯作者：
Zestos, Alexander G.

Carbon Nanotube Yarn Microelectrodes Promote High Temporal Measurements of Serotonin Using Fast Scan Cyclic Voltammetry

DOI：
10.3390/s20041173
发表时间：
2020-02-01
期刊：
SENSORS
影响因子：
3.9
作者：
Mendoza, Alexander;Asrat, Thomas;Zestos, Alexander G.
通讯作者：
Zestos, Alexander G.

Polymer Modified Carbon Fiber Microelectrodes for Precision Neurotransmitter Metabolite Measurements

用于精确神经递质代谢物测量的聚合物改性碳纤维微电极

DOI：
10.1149/1945-7111/abcb6d
发表时间：
2020
期刊：
Journal of The Electrochemical Society
影响因子：
3.9
作者：
Wonnenberg, Pauline;Cho, Whirang;Liu, Favian;Asrat, Thomas;Zestos, Alexander G.
通讯作者：
Zestos, Alexander G.

Carbon Fiber Multielectrode Arrays for Multiplexing Neurotransmitter Detection in Heterogeneous Brain Regions

用于异质脑区域多重神经递质检测的碳纤维多电极阵列