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Can tight linkage mimic pleiotropy during speciation? The effects and evolution of recombination between mating and local-adaptation loci.

紧密连锁可以模拟物种形成过程中的多效性吗？

基本信息

批准号：
1939290
负责人：
Maria Servedio
金额：
$ 45.8万
依托单位：
University of North Carolina at Chapel Hill
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-15 至 2023-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1939290&HistoricalAwards=false
关键词：
tight linkage mimic pleiotropy during

项目摘要

This research will develop mathematical models that examine the evolutionary processes by which one species splits into two: speciation. It has been thought that the genes that are uniquely important in promoting speciation are those that have dual functions that both allow the survival of individuals in their environment and allow individuals to attract mates of the same species. However, such genes appear to be quite rare. Some evidence exists that close physical proximity on a chromosome of genes involved in these two functions (survival and mate attraction) may also be very effective in allowing populations of recently diverged species that then come in contact to maintain their identity. The research will further explore the conditions under which close proximity of these genes mimics the properties of one gene with two functions, both in the maintenance of species and in the generation of new species. The researchers will also develop and distribute curriculum materials for teaching biology majors how to approach questions using mathematical modeling. The project will address these questions through mathematical modeling using a combination of population-genetic and individual-based approaches. These models will first address whether tight linkage of genes under ecologically divergent selection and genes that are the targets of assortative mating can mimic a single pleiotropic gene with these functions, concentrating on the evolution of choosiness during assortative mating. Next, the researchers will address whether traits under divergent selection and those used in mate choice will evolve to co-localize during the process of speciation with gene flow. This will be explored both by assessing the evolution of modifiers of recombination rate and by examining the fate of standing variation of genes when ecological and mating traits are controlled by many loci across the genome.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项研究将开发数学模型，研究一个物种分裂为两个物种的进化过程：物种形成。人们一直认为，在促进物种形成方面唯一重要的基因是那些具有双重功能的基因，这些基因既允许个体在其环境中生存，又允许个体吸引同一物种的配偶。然而，这样的基因似乎相当罕见。一些证据表明，在涉及这两个功能(生存和吸引配偶)的基因的染色体上的密切物理接近，也可能非常有效地允许最近分离的物种的种群保持自己的身份。这项研究将进一步探索这些基因的紧密接近在何种条件下模仿具有两种功能的一个基因的性质，在物种维持和新物种的产生中都是如此。研究人员还将开发和分发课程材料，教授生物学专业的学生如何使用数学建模来解决问题。该项目将通过使用群体遗传学和基于个体的方法相结合的数学建模来解决这些问题。这些模型将首先解决生态差异选择下的基因紧密连锁和作为分类交配目标的基因是否可以模仿具有这些功能的单个多效性基因，集中在分类交配过程中挑剔的进化。接下来，研究人员将研究分化选择下的特征和用于配偶选择的特征是否会在物种形成和基因流动的过程中进化为共同定位。这将通过评估重组率修饰物的进化和检查当生态和交配特征由基因组上的许多基因座控制时基因的持续变异的命运来探索。这一奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。