Can tight linkage mimic pleiotropy during speciation? The effects and evolution of recombination between mating and local-adaptation loci.

紧密连锁可以模拟物种形成过程中的多效性吗？

基本信息

批准号：
1939290
负责人：
Maria Servedio
金额：
$ 45.8万
依托单位：
University of North Carolina at Chapel Hill
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-15 至 2023-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1939290&HistoricalAwards=false
关键词：
tight linkage mimic pleiotropy during

项目摘要

This research will develop mathematical models that examine the evolutionary processes by which one species splits into two: speciation. It has been thought that the genes that are uniquely important in promoting speciation are those that have dual functions that both allow the survival of individuals in their environment and allow individuals to attract mates of the same species. However, such genes appear to be quite rare. Some evidence exists that close physical proximity on a chromosome of genes involved in these two functions (survival and mate attraction) may also be very effective in allowing populations of recently diverged species that then come in contact to maintain their identity. The research will further explore the conditions under which close proximity of these genes mimics the properties of one gene with two functions, both in the maintenance of species and in the generation of new species. The researchers will also develop and distribute curriculum materials for teaching biology majors how to approach questions using mathematical modeling. The project will address these questions through mathematical modeling using a combination of population-genetic and individual-based approaches. These models will first address whether tight linkage of genes under ecologically divergent selection and genes that are the targets of assortative mating can mimic a single pleiotropic gene with these functions, concentrating on the evolution of choosiness during assortative mating. Next, the researchers will address whether traits under divergent selection and those used in mate choice will evolve to co-localize during the process of speciation with gene flow. This will be explored both by assessing the evolution of modifiers of recombination rate and by examining the fate of standing variation of genes when ecological and mating traits are controlled by many loci across the genome.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项研究将开发数学模型，该模型检查一个物种将一个物种分为两者的进化过程：物种形成。人们认为，在促进物种物种方面非常重要的基因是具有双重功能的基因，这些功能都允许个体在其环境中的生存并允许个人吸引同一物种的伴侣。但是，这种基因似乎很少见。有一些证据表明，这两个功能涉及的基因染色体（生存和伴侣吸引力）近距离物理接近也可能非常有效地允许最近散开的物种的种群，然后接触以维持其身份。该研究将进一步探讨这些基因在维持物种和新物种的生成中都具有两个功能的一个基因的特性，这些基因的近距离模仿了一个基因的性质。研究人员还将开发和分发课程材料，以教授生物学专业的专业如何使用数学建模来解决问题。该项目将通过数学建模来解决这些问题，结合种群基因和基于个体的方法。这些模型将首先解决在生态不同的选择下的基因紧密连接和作为分类交配靶标的基因是否可以模仿这些功能的单个Pleiotiotropic基因，从而集中于分类交配过程中选择性选择的演变。接下来，研究人员将解决在不同选择下的性状以及在伴侣选择中使用的特征是否会在与基因流相形的物种过程中共定位。这将通过评估重组率修饰符的演变以及检查基因组的生态和交配特征的命运的命运来探讨这一点。该奖项反映了NSF的法定任务，并通过基金会的知识优点和广泛的影响来评估NSF的法定任务，并被认为是值得的。