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CAREER: Multiscale Mechanical Characterization of Bone Fracture Healing

职业：骨折愈合的多尺度力学表征

基本信息

批准号：
1943287
负责人：
Hannah Dailey
金额：
$ 50.6万
依托单位：
Lehigh University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1943287&HistoricalAwards=false
关键词：
CAREER Multiscale Mechanical Characterization Bone

项目摘要

This Faculty Early Career Development (CAREER) grant will address an important unsolved biomechanical problem: there is no non-invasive technique to measure bone fracture healing in living animals and humans. This research program will use computed tomography (CT) scans to create anatomically accurate 3D models of healing bones. These models will be used to measure how much healing has occurred. The models can also detect if healing has failed. This approach uses engineering simulation tools to carry out virtual mechanical tests, which will measure the mechanical strength of the healing bone. This will assess healing without the need for direct physical interaction with an animal or human patient. The bone models will adapt to load-bearing just like bones behave in the body - a novel feature of this work. These results will advance a new paradigm of non-invasive biomechanics-driven methods for measuring bone fracture healing and have impact on both science and society. The long-term benefit to society will be to develop similar tools to detect problems with bone healing much earlier than is currently possible, which may ultimately lead to better care at lower cost. The research is closely integrated with an educational outreach plan. Outreach activities are aimed at improving the retention of women in mechanical engineering, both locally and nationally. The combined outcomes of the research and education plans will support the investigator's career in non-invasive mechanical properties measurement of bone.The overall objective of this research is to characterize the structural mechanics of bone fracture callus, an important but under-studied musculoskeletal tissue. The specific technical objectives are: (1) define and validate a scaling law for modeling the density-dependent mechanical properties of fracture callus, (2) develop a collection of multiaxial virtual mechanical tests for detecting failed bone healing (nonunion) based on organ-level rigidity and tissue-level stress concentrations, and (3) characterize the structural organization of fracture callus and measure remodeling at the bone-callus boundary as quantitative indicators of healing speed. This work will be accomplished using new image analysis algorithms, structural finite-element modeling, and high-performance computing (HPC) enabled optimization methods. In this project, we will show how routine clinical imaging can be used to quantify the mechanics, organization, and remodeling stage of a healing fracture. The methods developed through this program will have a transformative impact on the interdisciplinary community of researchers studying bone healing by enabling quantitative in vivo assessment of structural healing and definitive diagnosis of failed healing when it occurs. Through associated outreach activities, this award will also address evidence-based drivers of female under-representation in mechanical engineering, both within the PI’s institution and nationally in partnership with the Perry Initiative.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该学院早期职业发展（CAREER）资助将解决一个重要的未解决的生物力学问题：没有非侵入性技术来测量活体动物和人类的骨折愈合。该研究计划将使用计算机断层扫描（CT）扫描来创建愈合骨骼的解剖学精确3D模型。这些模型将被用来衡量有多少愈合发生。模型还可以检测治疗是否失败。这种方法使用工程模拟工具进行虚拟力学测试，测量愈合骨的机械强度。这将在不需要与动物或人类患者直接物理交互的情况下评估愈合。骨骼模型将适应承重，就像骨骼在体内的行为一样-这是这项工作的一个新特点。这些结果将推动一种新的非侵入性生物力学驱动的方法来测量骨折愈合，并对科学和社会产生影响。对社会的长期利益将是开发类似的工具来检测骨愈合问题，比目前可能的要早得多，这最终可能导致以更低的成本提供更好的护理。这项研究与教育推广计划密切结合。外联活动的目的是在地方和国家两级提高妇女在机械工程领域的留用率。研究和教育计划的综合成果将支持研究者在骨的非侵入性力学性能测量方面的职业生涯。本研究的总体目标是表征骨折骨痂的结构力学，骨痂是一种重要但研究不足的肌肉骨骼组织。具体的技术目标是：（1）定义并验证用于对骨折骨痂的密度依赖性机械特性进行建模的标度律，（2）开发用于检测失败的骨愈合的多轴虚拟机械测试的集合（骨不连）基于器官水平刚度和组织水平应力集中，和（3）表征骨折骨痂的结构组织并测量骨-骨痂边界处的重塑作为愈合速度的定量指标。这项工作将使用新的图像分析算法，结构有限元建模和高性能计算（HPC）启用优化方法来完成。在这个项目中，我们将展示如何使用常规临床成像来量化愈合骨折的力学，组织和重塑阶段。通过该计划开发的方法将对研究骨愈合的跨学科研究人员社区产生变革性影响，使结构愈合的定量体内评估和愈合失败时的明确诊断成为可能。通过相关的推广活动，该奖项还将解决在PI的机构内和全国范围内与佩里倡议合作的机械工程领域女性代表性不足的循证驱动因素。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。