The role of NLRP3-inflammasome in lupus nephritis

NLRP3炎症小体在狼疮性肾炎中的作用

• 批准号: 240385447
• 负责人: Professor Dr. Maciej Lech, Ph.D.
• 金额: --
• 依托单位: Arbeitsgruppe Klinische Biochemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/240385447?language=en
• 关键词: role; NLRP3; inflammasome; lupus; nephritis

Inflammsomes are key regulators of innate, adaptive and host responses that inspect intracellular compartments for presence of PAMPs and DAMPs. Inflammasome activation was shown to contribute to inflammatory responses, hence we hypothesized that Caspase-1, IL-18, IL-1R, ASC and NLRP3 molecules may play a significant role in autoimmunity and auto-inflammatory tissue injury. To evaluate the functional role of these molecules in the pathogenesis of SLE we are going to generate Caspase-1, IL-18, IL-1R, NLRP3 and ASC-deficient C57BL/6-lpr/lpr mice.

炎症体是先天、适应性和宿主反应的关键调节因子，它们检查细胞内是否存在PAMP和DAMP。炎症小体的激活有助于炎症反应，因此我们推测Caspase-1、IL-18、IL-1R、Asc和NLRP3分子可能在自身免疫和自身炎症组织损伤中发挥重要作用。为了评估这些分子在SLE发病机制中的功能作用，我们将建立Caspase-1、IL-18、IL-1R、NLRP3和ASC缺陷的C57BL/6-LPR/LPR小鼠。

项目成果

Expression profiling by real-time quantitative polymerase chain reaction (RT-qPCR).

• DOI: 10.1007/978-1-4939-0882-0_13
• 发表时间: 2014-01-01
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Lech, Maciej;Anders, Hans-Joachim
• 通讯作者: Anders, Hans-Joachim

NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling

• DOI: 10.1136/annrheumdis-2014-205496
• 发表时间: 2015-12-01
• 期刊: ANNALS OF THE RHEUMATIC DISEASES
• 影响因子: 27.4
• 作者: Lech, Maciej;Lorenz, Georg;Anders, Hans-Joachim
• 通讯作者: Anders, Hans-Joachim

Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis

• DOI: 10.4049/jimmunol.1601982
• 发表时间: 2017-08-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Steiger, Stefanie;Kumar, Santhosh V.;Lech, Maciej
• 通讯作者: Lech, Maciej