REU Site: SURFing the Interface between Chemistry and Biology

REU 网站：探索化学与生物学之间的界面

• 批准号: 1950820
• 负责人: Katrin Karbstein
• 金额: $ 39.92万
• 依托单位: The Scripps Research Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950820&HistoricalAwards=false
• 关键词: REU; Site; SURFing; Interface; between

This REU Site award to The Scripps Research Institute is supported by the Department of Defense ASSURE program thru a partnership with the NSF REU program. The REU is located in Jupiter, Florida, will support the training of 10 students for 10 weeks during the summers of 2020-2022. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities or from an under-represented group, will be trained in the program. Students will learn how research is designed, conducted, and presented, and many will present the results of their work at scientific conferences, and/or through community outreach and social media. Assessment of the program will be done through the online SALG URSSA tool. Students will be tracked after the program in order to determine their career paths.Mirroring the highly interdisciplinary nature of Scripps’ faculty research, the program at the Scripps Research Institute Florida is an experience at the interface between chemistry and biology. Projects include aging studies in Drosophila, the study of ribosome assembly in yeast, the molecular basis for memory formation, and many others. A strong chemistry program allows for tool development to probe key biological processes such as glycan-mediated protein quality control, RNA transport to the dendrite, or the molecular basis for human diseases. Students will carry out their own research projects under the mentorship of experienced lab personnel and the supervision of world experts in their field. In addition to this hands-on experience of cutting-edge research, students participate in a weekly seminar series to broaden their perspectives on diverse scientific fields, as well as a workshop series to prepare them for graduate school (applications). Student satisfaction and learning outcomes will be assessed using online questionnaires, individual meetings with the PI and coordinator, and via mentor surveys. Applications are accepted online at https://education.scripps.edu/undergraduate/summer-research/reu-programs/ and due by 2/15 of each year. Student selection is based on transcripts, statements of purpose and letters of recommendation, and takes into consideration a student’s future potential for scientific research, as well as her/his interest in our program. More information about the program is available by visiting https://education.scripps.edu/undergraduate/summer-research/reu-programs/, or by contacting the PI (Dr. Katrin Karbstein at [e-mail]) or the program coordinator (Dr. Rosie Albarran-Zeckler at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

授予斯克里普斯研究所的REU场地奖由国防部保证计划通过与NSF REU计划的合作伙伴关系提供支持。REU位于佛罗里达州的朱庇特，将在2020-2022年夏季为10名学生提供为期10周的培训。预计共有30名学生将在该方案中接受培训，这些学生主要来自研究机会有限的学校或代表性不足的群体。学生将学习研究是如何设计、进行和展示的，许多人将在科学会议上展示他们的工作成果，和/或通过社区宣传和社交媒体。将通过SALG Urssa在线工具对该方案进行评估。项目结束后，将对学生进行跟踪，以确定他们的职业道路。佛罗里达州斯克里普斯研究所的这个项目是化学和生物之间的一次体验，反映了斯克里普斯教师研究的高度跨学科性质。项目包括果蝇衰老研究，酵母核糖体组装研究，记忆形成的分子基础，以及许多其他研究。强大的化学程序允许开发工具来探索关键的生物过程，如多糖介导的蛋白质质量控制、RNA到树突的运输，或人类疾病的分子基础。学生将在有经验的实验室人员的指导下和各自领域的世界专家的监督下开展自己的研究项目。除了这种前沿研究的实践经验外，学生们还参加每周一次的系列研讨会，以拓宽他们对不同科学领域的看法，以及一系列研讨会，为他们进入研究生院(申请)做准备。学生的满意度和学习结果将通过在线问卷、与PI和协调员的个别会议以及通过导师调查进行评估。申请在https://education.scripps.edu/undergraduate/summer-research/reu-programs/网站在线接受，截止日期为每年的2/15。学生的选择是基于成绩单、目的声明和推荐信，并考虑到学生未来的科学研究潜力，以及她/他对我们项目的兴趣。有关该计划的更多信息，请访问https://education.scripps.edu/undergraduate/summer-research/reu-programs/，或联系国际组织(Katrin Karbstein博士，电子邮件：[e-mail])或计划协调员(Rosie Albarran-Zeckler博士，电子邮件：[e-mail])。该奖项反映了美国国家科学基金会的法定使命，并已通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules

使用异双功能分子在细胞中进行靶向蛋白质乙酰化

• DOI: 10.1021/jacs.1c07850
• 发表时间: 2021
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Wang, Wesley W.;Chen, Li-Yun;Wozniak, Jacob M.;Jadhav, Appaso M.;Anderson, Hayden;Malone, Taylor E.;Parker, Christopher G.
• 通讯作者: Parker, Christopher G.