Towards Absolute Asymmetric Synthesis
走向绝对不对称合成
基本信息
- 批准号:1954262
- 负责人:
- 金额:$ 49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With this award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting research by Professor Tehshik Yoon of the University of Wisconsin–Madison’s Chemistry Department. Professor Yoon is interested in controlling the shape of molecules. Many important organic molecules, including drug molecules and elementary biomolecules such as amino acids and sugars can exist in either left- or right-handed forms. These two mirror-image forms interact with biological systems in very different ways, so it is critically important to control the handedness in the synthesis of organic molecules. Professor Yoon leads a team of undergraduate and graduate students to investigate if light can be used to control the handedness of organic molecules. To do so, they have created a family of catalysts that absorb light and then induce molecular transformations with excellent control over the shape of the resulting products. This work takes an interdisciplinary approach combining multiple areas of the chemical sciences. In addition, students in the Yoon laboratory working on this project are helping to disseminate scientific research to novice science students by producing a new podcast. The first season of this podcast has been downloaded over 2500 times through a variety of free podcasting platforms.The chiral photocatalysts in this project are octahedral iridium complexes whose ligands are arranged about the metal with well-defined helical chirality. This class of compounds constitutes an attractive starting point for these studies: they possess a robust and well-studied photochemistry; they are quite effective photosensitizers for a range of organic transformations; and they can easily be synthesized in stereochemically pure form. The newly designed chiral photosensitizers resulting from these studies are remarkably efficient asymmetric catalysts, and a multidisciplinary approach to studying their reactions reveals a rich variety of mechanisms. These studies offer a training opportunity for a diverse group of undergraduate and graduate students in scientific fields of significant contemporary interest to the chemical industries.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
通过这一奖项,美国国家科学基金会化学部的化学合成计划支持了威斯康星大学麦迪逊分校化学系的特赫希克·尹教授的研究。尹教授对控制分子的形状很感兴趣。许多重要的有机分子,包括药物分子和基本的生物分子,如氨基酸和糖,可以左手或右手形式存在。这两种镜像形式以非常不同的方式与生物系统相互作用,因此在有机分子的合成中控制左旋手是至关重要的。尹教授带领一个由本科生和研究生组成的团队,研究光是否可以用来控制有机分子的左右手。为了做到这一点,他们创造了一系列催化剂,这些催化剂可以吸收光线,然后诱导分子转化,并对结果产品的形状进行出色的控制。这项工作采取了跨学科的方法,结合了化学科学的多个领域。此外,参与这个项目的Yoon实验室的学生正在通过制作一个新的播客来帮助向理科新手传播科学研究。这一季的播客第一季在各种免费播客平台上的下载量已超过2500次。本项目中的手性光催化剂是八面体Ir络合物,其配体以明确的螺旋手性排列在金属周围。这类化合物构成了这些研究的一个有吸引力的起点:它们具有强大的和研究得很好的光化学;它们是一系列有机转化的相当有效的光敏剂;它们可以很容易地以立体化学纯形式合成。从这些研究中得到的新设计的手性光敏剂是非常有效的不对称催化剂,多学科方法研究它们的反应揭示了丰富多样的机理。这些研究为不同群体的本科生和研究生提供了培训机会,这些领域是当代化学工业感兴趣的重要科学领域。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Highly Enantioselective 6π Photoelectrocyclizations Engineered by Hydrogen Bonding
- DOI:10.1021/jacs.3c10782
- 发表时间:2023-12-05
- 期刊:
- 影响因子:15
- 作者:Swords,Wesley B.;Lee,Hanna;Yoon,Tehshik P.
- 通讯作者:Yoon,Tehshik P.
Chiral Photocatalyst Structures in Asymmetric Photochemical Synthesis.
- DOI:10.1021/acs.chemrev.1c00467
- 发表时间:2022-01-26
- 期刊:
- 影响因子:62.1
- 作者:Genzink MJ;Kidd JB;Swords WB;Yoon TP
- 通讯作者:Yoon TP
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Tehshik Yoon其他文献
Tehshik Yoon的其他文献
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{{ truncateString('Tehshik Yoon', 18)}}的其他基金
Designer Photocatalysts for Asymmetric Photochemistry
用于不对称光化学的设计师光催化剂
- 批准号:
2349003 - 财政年份:2024
- 资助金额:
$ 49万 - 项目类别:
Standard Grant
CAREER: Catalyst-controlled Activation of Oxaziridines
职业:氧氮丙啶的催化剂控制活化
- 批准号:
0645447 - 财政年份:2007
- 资助金额:
$ 49万 - 项目类别:
Continuing Grant
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使用圆偏振光作为不对称源,通过螺旋选择性聚合和选择性降解反应进行绝对不对称合成
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使用圆偏振光作为手性源,通过手性扩增螺旋选择性聚合合成绝对不对称聚合物
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17K19153 - 财政年份:2017
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Developments of the absolute asymmetric synthesis of optically active derivatives of amino acids with the dynamic preferential crystallization
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- 批准号:
26410124 - 财政年份:2014
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Absolute self-asymmetric polymerization : sponteneous, self catalyzed, and amplificated asymmetric polymerization
绝对自不对称聚合:自发、自催化和放大不对称聚合
- 批准号:
23655100 - 财政年份:2011
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A Novel Absolute Asymmetric Synthesis Using Photoracemization and Preferential Crystallization
利用光外消旋化和优先结晶的新型绝对不对称合成
- 批准号:
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A Novel Strategy of Absolute Asymmetric Synthesis via Spin Coating
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利用冷冻手性进行自发结晶和绝对不对称合成产生的手性记忆
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5397449 - 财政年份:2003
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Research Grants