MRI: Acquisition of a 400 MHz NMR Spectrometer to Facilitate Research and Undergraduate Research Training

这一重大研究仪器奖为购买400 MHz核磁共振(核磁共振)光谱仪提供资金，以支持在有机金属、有机、生物无机和生物化学方面的研究计划。使用新的核磁共振进行的研究包括金属-金属键对基于配体的反应性的影响的研究，开发尖端的铜催化点击方法来合成作为发光材料的荧光团，分析影响拟南芥侧根形成的分子，以及锌结合多肽中的铜相互作用，以及开发具有捕光性能的用于太阳能转换的卟啉。这些项目利用了新型核磁共振的多核(例如31P、19F、11B)和变温能力，并利用提高的灵敏度来高效地从常规1D和复杂的2D实验中获取数据。在Macalester学院，教职员工和学生积极的学术活动促进了新知识的创造，并确保下一代科学家接受最先进的培训。新的核磁共振使本科生的高质量研究培训成为可能。核磁共振也被用于暑期研究项目，以激发来自代表性不足群体的高中生对科学的兴趣。核磁共振研究的结果将通过摘要和同行评议的出版物以及学生和教职员工积极参加专业会议的方式广泛传播。

This Major Research Instrumentation award funds the acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer to sustain research programs in organometallic, organic, bioinorganic, and biochemistry. Research performed using the new NMR includes studies on the impact of metal-metal bonds on ligand-based reactivity, development of cutting-edge Cu-catalyzed click methodology for the syntheses of fluorophores as light-emitting materials, analysis of molecules that influence lateral root formation in Arabidopsis thaliana , and copper interactions in zinc-binding peptides and developing porphyrins with light-harvesting properties for solar energy conversion applications. These projects utilize the multinuclear (e.g., 31P, 19F, 11B) and variable temperature capabilities of the new NMR and take advantage of the increased sensitivity to permit efficient acquisition of data from routine 1D and sophisticated 2D experiments. At Macalester College, vigorous scholarly activity by faculty and students facilitates the creation of new knowledge and ensures that the next generation of scientists receives state-of-the-art training. High quality research training of undergraduates is enabled by the new NMR. The NMR is also used in summer research programs to stimulate interest in science among high school students from underrepresented groups. Results from the NMR studies will be broadly disseminated through abstracts and peer reviewed publications, as well as by active participation of students and faculty at professional meetings.