I-Corps: A Mobile-Based Opioid Overdose Alerting System

I-Corps项目更广泛的影响/商业潜力是开发一种智能可穿戴监测器，能够提供临床级别的肺功能测量（例如，潮气量、用力呼气量、分钟通气等）。然而，虽然适用于住院治疗，但目前的解决方案在提供远程医疗和自我管理方面存在缺陷。该项目的价值主张是为急性或慢性呼吸系统疾病患者提供一种非侵入性连续肺功能监测仪，用于自我管理、监测或预防疾病恶化。这种监测器将作为一种可伸缩的、可穿戴的传感器来实现，它可以估计呼吸时胸腔大小的变化。这种技术的发展在减少致命性阿片类药物过量、哮喘和copd相关急诊就诊以及通过远程医疗支持肺部康复方面具有巨大潜力。这个I-Corps项目旨在探索无线单波段可拉伸硅胶传感器的商业潜力，当佩戴在胸前时，它能够测量潮汐量，从而可以得出其他肺功能的测量（例如，用力呼气量，分钟通气等）。目前，肺功能检测、肺活量测定、肺活量测定、呼吸感应容积脉搏波、脉搏血氧测定是生命监测和肺功能评估的临床标准。到目前为止，呼吸感应式容积描记仪是监测潮气量的侵入性最小的技术，它需要两个带——一个戴在胸前，一个戴在腹部。脉搏血氧仪是一种较差的技术，用于早期检测呼吸窘迫（俗称呼吸短促），因为氧合变化需要时间。相反，例如，呼吸抑制可以通过潮汐量的变化迅速检测到。然而，能够监测潮气量的血管造影和呼吸感应容积描记仪很笨重，不适合在临床环境之外使用。现在有新的证据表明，通过测量胸腔周长的变化，你可以使用一个能够与身体确认的可拉伸传感器，以高保真度估计潮汐量。将这种传感器技术集成到带有无线传感器模块的可穿戴设备中，有可能为远程医疗监测和交付开辟新的途径。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is to develop a smart wearable monitor capable of delivering clinical-grade measurements of lung function (e.g., tidal volume, forced expiratory volume, minute ventilation, etc.). However, while suitable for in-hospital care, the current solutions present drawbacks in the delivery of telecare and self-management. The value proposition of this project is to present a non-invasive continuous pulmonary function monitor for persons with an acute or chronic respiratory illness to self-manage, monitor, or prevent exacerbations of their illness. This monitor would be implemented as a stretchable, wearable sensor that estimates changes in the size of the ribcage from breathing. The development of such a technology has significant potential for reducing fatal opioid overdoses, asthma- and COPD-related emergency department visits, and support pulmonary rehabilitation delivered via telemedicine.This I-Corps project aims to explore the commercial potential for a wireless single-band stretchable silicone sensor, which when worn around the chest is capable of measuring tidal volume from which other measures of lung function can be derived (e.g., forced expiratory volume, minute ventilation, etc.). Currently, lung function testing, spirometry, capnometry, respiratory inductance plethysmography, and pulse oximetry are the clinical standard for vital monitoring and assessing lung function. Until now, respiratory inductance plethysmography monitors, which requires two bands – a chest-worn and abdomen worn band, is the least invasive technology for tidal volume monitoring. Pulse oximetry is an inferior technology for the early detection of respiratory distress (or colloquially, shortness of breath) because changes in oxygenation take time. In contrast, for example, respiratory depression can be quickly detected by changes in tidal volume. However, capnography and respiratory inductance plethysmography monitors, which are capable of monitoring tidal volume, are cumbersome and ill-suited for use outside a clinical setting.New evidence has now demonstrated that by measuring the change in circumference of the ribcage, you can estimate tidal volume with high fidelity using a stretchable sensor capable of confirming to the body. Integrating this sensor technology into a wearable device with a wireless sensor module has the potential to unlock new avenues for telehealth monitoring and delivery.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.