I-Corps: A Mobile-Based Opioid Overdose Alerting System

I-Corps：基于移动设备的阿片类药物过量警报系统

• 批准号: 2001018
• 负责人: Jeremy Cushman
• 金额: $ 5万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2001018&HistoricalAwards=false
• 关键词: Corps; Mobile; Based; Opioid; Overdose

The broader impact/commercial potential of this I-Corps project is to develop a smart wearable monitor capable of delivering clinical-grade measurements of lung function (e.g., tidal volume, forced expiratory volume, minute ventilation, etc.). However, while suitable for in-hospital care, the current solutions present drawbacks in the delivery of telecare and self-management. The value proposition of this project is to present a non-invasive continuous pulmonary function monitor for persons with an acute or chronic respiratory illness to self-manage, monitor, or prevent exacerbations of their illness. This monitor would be implemented as a stretchable, wearable sensor that estimates changes in the size of the ribcage from breathing. The development of such a technology has significant potential for reducing fatal opioid overdoses, asthma- and COPD-related emergency department visits, and support pulmonary rehabilitation delivered via telemedicine.This I-Corps project aims to explore the commercial potential for a wireless single-band stretchable silicone sensor, which when worn around the chest is capable of measuring tidal volume from which other measures of lung function can be derived (e.g., forced expiratory volume, minute ventilation, etc.). Currently, lung function testing, spirometry, capnometry, respiratory inductance plethysmography, and pulse oximetry are the clinical standard for vital monitoring and assessing lung function. Until now, respiratory inductance plethysmography monitors, which requires two bands – a chest-worn and abdomen worn band, is the least invasive technology for tidal volume monitoring. Pulse oximetry is an inferior technology for the early detection of respiratory distress (or colloquially, shortness of breath) because changes in oxygenation take time. In contrast, for example, respiratory depression can be quickly detected by changes in tidal volume. However, capnography and respiratory inductance plethysmography monitors, which are capable of monitoring tidal volume, are cumbersome and ill-suited for use outside a clinical setting.New evidence has now demonstrated that by measuring the change in circumference of the ribcage, you can estimate tidal volume with high fidelity using a stretchable sensor capable of confirming to the body. Integrating this sensor technology into a wearable device with a wireless sensor module has the potential to unlock new avenues for telehealth monitoring and delivery.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目更广泛的影响/商业潜力是开发一种智能可穿戴监测器，能够提供临床级的肺功能测量（例如，潮气量、用力呼气量、每分钟通气量等）。 然而，虽然适合于医院内护理，但目前的解决方案在远程护理和自我管理的交付方面存在缺陷。该项目的价值主张是为患有急性或慢性呼吸系统疾病的人提供一种无创连续肺功能监测仪，以自我管理，监测或预防其疾病的恶化。这个监测器将被实现为一个可伸缩的、可穿戴的传感器，它可以估计呼吸引起的胸腔大小的变化。 这种技术的发展在减少致命的阿片类药物过量、哮喘和COPD相关的急诊科就诊以及通过远程医疗提供的肺康复支持方面具有巨大的潜力。这个I-Corps项目旨在探索无线单波段可伸缩硅胶传感器的商业潜力，其当佩戴在胸部周围时能够测量潮气量从而可以导出肺功能的其它测量（例如，用力呼气量、每分钟通气量等）。目前，肺功能测试、肺活量测定法、二氧化碳测定法、呼吸感应体积描记法和脉搏血氧测定法是用于生命监测和评估肺功能的临床标准。到目前为止，呼吸感应体积描记监测仪需要两个带-胸部佩戴和腹部佩戴带，是潮气量监测的侵入性最小的技术。脉搏血氧仪是一种用于早期检测呼吸窘迫（或通俗地说，呼吸短促）的较差技术，因为氧合的变化需要时间。相反，例如，呼吸抑制可以通过潮气量的变化快速检测。然而，二氧化碳监测仪和呼吸感应体积描记仪，能够监测潮气量，是笨重的，不适合在临床环境外使用。新的证据表明，通过测量胸腔周长的变化，你可以估计潮气量与高保真使用可伸缩的传感器能够确认身体。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。