Collaborative Research: Experimental and Computational Studies of Flow and Clogging of Deformable Particles under Confinement

合作研究:约束下可变形颗粒流动和堵塞的实验和计算研究

基本信息

  • 批准号:
    2002782
  • 负责人:
  • 金额:
    $ 20万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-05-15 至 2023-04-30
  • 项目状态:
    已结题

项目摘要

Squishy, deformable particles play an important role in many fields of science and engineering, from the biological cells to droplets of fatty oils in water that make up emulsions like mayonnaise, peanut butter, and milk. Microfluidic devices with tiny channels of varying widths are used to process mixtures of deformable particles and fluids and to manipulate DNA molecules. However, microfluidic devices frequently clog near constrictions, which is expensive since the device must be replaced when this occurs. Clogging has been studied extensively for rigid particles, like grains flowing out of a silo, but clogging of deformable particles is less well understood. In particular, it is unclear how particle deformability and stickiness or cohesion affects clogging. For example, will deformable and cohesive particles change shape and flow past each other at constrictions, or will they form arches and clog the system? This project combines experiments of emulsion droplets flowed through microfluidic devices with novel computer simulations of deformable particles to understand how they clog. This work will aid in future designs of critical microfluidic devices involved in industrial processing, filtration, and analysis of biological samples of cell-fluid mixtures.Flow-induced jamming, or clogging, is observed across a wide range of systems, from flows of granular materials in silos to flows of blood cells through veins. Clogging is well studied in the case of hard, frictional grains, but is poorly understood when particles are deformable and cohesive. This project employs experiments of suspensions of emulsion droplets with tunable deformability and adhesion flowed through microfluidic devices, along with novel simulations of flows of explicitly deformable particles designed to model emulsion droplets. The combined experimental-computational approach can disentangle the effects of deformability, particle mechanical response, and adhesion on clogging probability. One key focus is the role of particle rearrangements during clogs in unjamming the suspensions. During clogs of granular materials, particles are static and clogs have long lifetimes. However, if particles are deformable, particle shape relaxation and stress redistribution in a clogged suspension can lead to intermittent clog release and avalanching. Additionally, this project will investigate how the Beverloo Law, which describes how flow rate changes with constriction width, changes in the case of deformable and adhesive particles. The combination of computational and experimental studies will aid the development of a comprehensive theoretical framework to predict when a clog will form given the particle properties, flow rate, and constriction width. With the increased use of microfluidic devices to analyze suspensions of colloidal particles and cells, a predictive framework for clogging based on single-particle properties like deformability, elasticity and adhesion is required to design the next generation of efficient high-throughput microfluidic devices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
黏糊糊的、可变形的颗粒在许多科学和工程领域中发挥着重要作用,从生物细胞到水中的脂肪油滴,这些脂肪油滴构成了蛋黄酱、花生酱和牛奶等乳液。 具有不同宽度的微小通道的微流体装置用于处理可变形颗粒和流体的混合物以及操纵DNA分子。然而,微流体装置经常在收缩部附近堵塞,这是昂贵的,因为当这种情况发生时必须更换装置。对于刚性颗粒(如从筒仓中流出的谷物)的堵塞已经进行了广泛的研究,但是对于可变形颗粒的堵塞还不太清楚。特别是,目前还不清楚颗粒的变形性和粘性或凝聚力如何影响堵塞。例如,可变形和粘性颗粒会改变形状并在收缩处彼此流过,还是会形成拱形并堵塞系统?该项目将乳液液滴流过微流体装置的实验与可变形颗粒的新型计算机模拟相结合,以了解它们如何堵塞。这项工作将有助于未来设计的关键微流控装置在工业处理,过滤和分析的生物样品的细胞-流体mixture. Flow诱导堵塞,或堵塞,观察到在广泛的系统,从流动的颗粒材料在筒仓通过静脉血细胞的流动。在硬的摩擦颗粒的情况下,堵塞被很好地研究,但是当颗粒是可变形的和内聚的时,却知之甚少。该项目采用了可调变形性和粘附性的乳液液滴悬浮液流过微流体装置的实验,沿着与明确可变形颗粒的流动的新模拟设计用于模拟乳液液滴。实验-计算相结合的方法可以解开变形能力,颗粒的机械响应,和粘附堵塞概率的影响。一个关键的焦点是在解除堵塞的悬浮液中的堵塞期间颗粒重排的作用。在颗粒材料堵塞期间,颗粒是静态的,堵塞的寿命很长。然而,如果颗粒是可变形的,则堵塞悬浮液中的颗粒形状松弛和应力重新分布可导致间歇性堵塞释放和雪崩。此外,本项目将研究如何贝弗卢定律,它描述了如何流速与收缩宽度的变化,在可变形和粘性颗粒的情况下变化。计算和实验研究的结合将有助于建立一个全面的理论框架,以预测在给定颗粒特性、流速和收缩宽度的情况下何时会形成堵塞。随着微流控设备在分析胶体颗粒和细胞悬浮液方面的应用越来越多,基于单颗粒特性(如变形性)的堵塞预测框架,弹性和附着力是设计下一代高效高该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响进行评估,被认为值得支持审查标准。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Bridging particle deformability and collective response in soft solids
桥接软固体中的颗粒变形性和集体响应
  • DOI:
    10.1103/physrevmaterials.5.055605
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Treado, John D.;Wang, Dong;Boromand, Arman;Murrell, Michael P.;Shattuck, Mark D.;O'Hern, Corey S.
  • 通讯作者:
    O'Hern, Corey S.
Shear response of granular packings compressed above jamming onset
堵塞开始时压缩颗粒填料的剪切响应
  • DOI:
    10.1103/physreve.103.022902
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Wang, Philip;Zhang, Shiyun;Tuckman, Philip;Ouellette, Nicholas T.;Shattuck, Mark D.;O'Hern, Corey S.
  • 通讯作者:
    O'Hern, Corey S.
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Corey O'Hern其他文献

Understanding the Native Fluctuation of Protein Cores
  • DOI:
    10.1016/j.bpj.2019.11.307
  • 发表时间:
    2020-02-07
  • 期刊:
  • 影响因子:
  • 作者:
    Zhe Mei;John Treado;Lynne J. Regan;Zachary Levine;Corey O'Hern
  • 通讯作者:
    Corey O'Hern
The Free Energy Reaction Path Theory of Reliable Protein Folding
  • DOI:
    10.1016/j.bpj.2008.12.3088
  • 发表时间:
    2009-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Gregg Lois;Jerzy Blawzdziewicz;Corey O'Hern
  • 通讯作者:
    Corey O'Hern

Corey O'Hern的其他文献

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{{ truncateString('Corey O'Hern', 18)}}的其他基金

Modeling the Structural and Mechanical Properties of Tissue During Zebrafish Tailbud Elongation
模拟斑马鱼尾芽伸长过程中组织的结构和力学特性
  • 批准号:
    2102789
  • 财政年份:
    2021
  • 资助金额:
    $ 20万
  • 项目类别:
    Continuing Grant
NSF REU Site: Research training in the biomedical sciences and engineering
NSF REU 网站:生物医学科学与工程研究培训
  • 批准号:
    2050777
  • 财政年份:
    2021
  • 资助金额:
    $ 20万
  • 项目类别:
    Continuing Grant
Biological Self Assembly: Tissue Mechanics of the Spongy Mesophyll in Flowers
生物自组装:花中海绵状叶肉的组织力学
  • 批准号:
    2029756
  • 财政年份:
    2020
  • 资助金额:
    $ 20万
  • 项目类别:
    Continuing Grant
4th International Conference on Packing Problems
第四届国际包装问题会议
  • 批准号:
    1926690
  • 财政年份:
    2019
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
REU Site: Interdisciplinary Research Training Across Biology, Physics, and Engineering
REU 网站:跨生物学、物理学和工程学的跨学科研究培训
  • 批准号:
    1755494
  • 财政年份:
    2018
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
16th Annual Northeastern Granular Materials Workshop; New Haven, Connecticut; June 8, 2018
第十六届东北颗粒材料研讨会;
  • 批准号:
    1834732
  • 财政年份:
    2018
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
The Origin of Geometric Friction and Cohesion
几何摩擦力和内聚力的起源
  • 批准号:
    1605178
  • 财政年份:
    2016
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
REU Site: Convergence of Research at the Interface of the Biological, Physical, and Engineering Sciences
REU 网站:生物、物理和工程科学交叉领域的研究融合
  • 批准号:
    1458609
  • 财政年份:
    2015
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
SYMPOSIUM: Support for U.S. Participants for the Symposium on "Statics and Dynamics of Dense Granular Matter," July 6 - 10, 2015, Madrid, Spain
研讨会:支持美国参与者参加“致密颗粒物质的静态和动力学”研讨会,2015 年 7 月 6 日至 10 日,西班牙马德里
  • 批准号:
    1460426
  • 财政年份:
    2015
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
Collaborative Research: Mechanics of Granular Acoustic Meta-materials with Engineered Particles and Packings
合作研究:带有工程颗粒和填料的粒状声学超材料的力学
  • 批准号:
    1462439
  • 财政年份:
    2015
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant

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