I-Corps: A more efficient, more effective, portable oxygen concentrator

I-Corps：更高效、更有效的便携式制氧机

• 批准号: 2009716
• 负责人: Soumyadipta Acharya
• 金额: $ 5万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2009716&HistoricalAwards=false
• 关键词: Corps; more; efficient; effective; portable

The broader impact/commercial potential of this I-Corps project is to improve the quality of life for patients on long term oxygen therapy (LTOT) as a result of chronic lung diseases through improved oxygen technology. Over 1 million Americans require LTOT to manage symptoms of hypoxemia and shortness of breath due to chronic lung disease. Although portable oxygen equipment exists, such as oxygen tanks or portable oxygen concentrators (POCs), many patients are faced with limitations with their equipment (oxygen duration, size and weight of devices, quantity of oxygen). More than a quarter of all oxygen users experience such challenges, severely affecting mobility, the ability to work and travel, and ultimately affecting quality of life. Improved technology in portable oxygen equipment can drastically improve the everyday lives of patients with the opportunity to rethink the current standards in managing oxygen delivery and improve patient care and quality of life.This I-Corps project proposes novel oxygen delivery and management technology to improve the efficiency and efficacy of current POC technology. The proposed system incorporates a new delivery modality of mixed high-flow air with oxygen to increase the treatable range of oxygen flow rates while providing additional dyspnea relief. The proposed system also automatically titrates oxygen delivery based on patient needs (SpO2) to limit oxygen waste and increase efficiency of current POCs. Current research is investigating the safety and efficacy of the novel flow modality and automatic titration in patients through multiple in-human studies. Preliminary results suggest a potential increase in exercise capacity over standard LTOT and a decrease in shortness of breath with the novel flow modality.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛影响/商业潜力是通过改进氧气技术来改善因慢性肺部疾病而接受长期氧气治疗（LTOT）的患者的生活质量。超过100万美国人需要LTOT来管理由于慢性肺部疾病引起的低氧血症和呼吸急促症状。尽管存在便携式氧气设备，例如氧气罐或便携式氧气浓缩器（POC），但许多患者面临其设备的限制（氧气持续时间、设备的尺寸和重量、氧气量）。超过四分之一的氧气使用者都面临着这样的挑战，严重影响了他们的行动能力、工作和旅行能力，并最终影响到生活质量。便携式氧气设备的改进技术可以极大地改善患者的日常生活，并有机会重新思考当前的氧气输送管理标准，改善患者护理和生活质量。I-Corps项目提出了新的氧气输送和管理技术，以提高当前POC技术的效率和功效。所提出的系统采用了一种新的输送方式，将高流量空气与氧气混合，以增加氧气流速的可治疗范围，同时提供额外的呼吸困难缓解。所提出的系统还根据患者需求（SpO 2）自动定时氧气输送，以限制氧气浪费并提高当前POC的效率。目前的研究正在通过多项人体研究调查新型血流模式和自动滴定在患者中的安全性和有效性。初步结果表明，运动能力的潜在增加超过标准LTOT和呼吸急促减少与新的流量model.This奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

Burden and Unmet Needs with Portable Oxygen in Patients on Long-Term Oxygen Therapy

• DOI: 10.1513/annalsats.202005-487oc
• 发表时间: 2021-09-01
• 期刊: ANNALS OF THE AMERICAN THORACIC SOCIETY
• 影响因子: 8.3
• 作者: Dakkak, Jessica;Tang, Wilson;Danoff, Sonye K.
• 通讯作者: Danoff, Sonye K.