Is FGF21 the master regulator of protein intake?

FGF21 是蛋白质摄入量的主要调节因子吗？

• 批准号: DP160101119
• 负责人: Prof Stephen Simpson
• 金额: $ 26.59万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101119
• 关键词: FGF21; master; regulator; protein; intake

The project plans to bring together two major, rapidly growing disciplines – nutritional geometry and metabolic signalling – to address a topic of fundamental biological significance: the regulation of protein intake. A specific capacity to regulate protein intake has been shown for organisms spanning slime moulds to humans, yet the controlling mechanisms remain elusive. The project aims to test the hypothesis that fibroblast growth factor 21, released from the liver under low protein nutrition, is a master regulator of protein intake. Understanding the mechanisms of protein appetite may have implications for organismal biology, understanding social interactions, the structure of food webs and the health and welfare of food and companion animals and humans.

该项目计划将两个快速发展的主要学科——营养几何和代谢信号——结合起来，以解决一个具有基本生物学意义的主题：蛋白质摄入的调节。从黏菌到人类的生物体都显示出调节蛋白质摄入的特殊能力，但控制机制仍然难以捉摸。该项目旨在验证一种假设，即低蛋白质营养下肝脏释放的成纤维细胞生长因子21是蛋白质摄入的主要调节剂。了解蛋白质食欲的机制可能对生物体生物学、理解社会互动、食物网结构以及食物、伴侣动物和人类的健康和福利具有重要意义。