Collaborative research: Physiological signatures of variable weaning strategies in wild primates
合作研究:野生灵长类动物不同断奶策略的生理特征
基本信息
- 批准号:2013888
- 负责人:
- 金额:$ 6.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Premature weaning can result in poor infant developmental outcomes and increased infant mortality; however, the social conditions that lead to premature weaning and its consequences are still poorly understood. The central goal of this project is to examine how stressful social conditions linked to the immigration of new adult males and/or poor maternal condition influence the likelihood of premature weaning, and, in turn how premature weaning then influences infant growth, gut microbial colonization, and the development of the immune system in a nonhuman primate model. Given the importance of early weaning as a hallmark of human evolution, developing comprehensive longitudinal models of this early life transition are valuable. In addition, the findings may serve as an animal model for understanding the costs and benefits of truncated or extended breastfeeding in modern humans. The project will provide rigorous scientific training to at least one post-doctoral fellow and several graduate and undergraduate students. The PIs will also engage in public outreach at local and international levels, contributing to scientific education and conservation efforts both domestically and abroad. This project examines the links between social factors, variable weaning strategies, and infant growth and immune system development in geladas. It draws on both cross-sectional and longitudinal data collected from infants aged 0-2.5 years to address the following goals: (1) Determine how social factors related to stressful demographic changes and/or maternal condition influence the timing of nursing cessation; (2) Identify how earlier weaning relative to infant size is related to stunted postnatal growth, altered gut microbial diversity and composition, and the concentration of urinary neopterin, a biomarker for cellular inflammation. Geladas are ideal for this research because their social system is characterized by frequent and stressful social upheavals that disrupt infant development and can even lead to infant mortality. Further, gelada females form strong dominance hierarchies that determine access to food, thus allowing researchers to address how social factors linked to poor maternal nutrition are associated with variable weaning strategies. Together, these attributes make geladas an excellent model system in which to study premature weaning. This study will be one of the first to integrate innovative methods in isotopic/elemental chemistry, genomics, endocrinology, and digital photogrammetry to examine the causes and consequences of premature weaning in wild primate infants, thus identifying some of the key mechanisms bridging early life social adversity to long-term developmental and health. Student trainees will have the opportunity to learn methods in behavioral data collection as well as various wet lab methods to characterize the composition of the gut microbiome and define weaning by the amount of milk vs. plant-origin carbon and nitrogen found in noninvasively collected fecal samples.
过早断奶会导致婴儿发育不良和婴儿死亡率增加;然而,导致过早断奶的社会条件及其后果仍然知之甚少。该项目的中心目标是研究与新成年雄性移民和/或母亲状况不佳有关的压力社会条件如何影响过早断奶的可能性,以及过早断奶如何影响婴儿生长,肠道微生物定植和非人灵长类动物模型中免疫系统的发育。鉴于早期断奶作为人类进化标志的重要性,开发这种早期生命过渡的全面纵向模型是有价值的。此外,这些发现可以作为了解现代人类缩短或延长母乳喂养的成本和效益的动物模型。该项目将为至少一名博士后研究员和几名研究生和本科生提供严格的科学培训。PI还将参与地方和国际层面的公共宣传,为国内外的科学教育和保护工作做出贡献。 本研究探讨社会因素、不同断奶策略与狮尾狒狒的婴儿生长及免疫系统发育之间的关系。本研究以0 ~ 2.5岁婴儿为研究对象,采用横断面和纵向研究方法,探讨以下问题:(1)社会因素与人口统计学变化和母亲状况的关系,对婴儿停止哺乳的时间有何影响;(2)确定相对于婴儿大小,较早断奶与出生后发育迟缓、肠道微生物多样性和组成改变的关系,以及尿中新蝶呤的浓度,新蝶呤是细胞炎症的生物标志物。狮尾狒狒是这项研究的理想对象,因为它们的社会系统以频繁和紧张的社会动荡为特征,这些动荡会破坏婴儿的发育,甚至会导致婴儿死亡。此外,狮尾狒狒女性形成强大的统治阶层,决定获得食物,从而使研究人员能够解决如何与产妇营养不良的社会因素与变量断奶策略。总之,这些属性使狒狒成为研究过早断奶的极好模型系统。这项研究将是第一个整合同位素/元素化学,基因组学,内分泌学和数字摄影测量学的创新方法,以研究野生灵长类动物婴儿过早断奶的原因和后果,从而确定一些关键机制,将早期生活社会逆境与长期发展和健康联系起来。学生学员将有机会学习行为数据收集方法以及各种湿实验室方法,以表征肠道微生物组的组成,并通过非侵入性收集的粪便样本中发现的牛奶与植物来源的碳和氮的量来定义断奶。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Assessing male gelada chest patches: color measurement and physiological mechanisms
- DOI:10.1007/s42991-021-00211-5
- 发表时间:2022-02-22
- 期刊:
- 影响因子:1.6
- 作者:DeLacey, Patricia M.;Perlman, Rachel F.;Bergman, Thore J.
- 通讯作者:Bergman, Thore J.
Vascularization underlies differences in sexually selected skin coloration in a wild primate
- DOI:10.1111/mec.17026
- 发表时间:2023-05-24
- 期刊:
- 影响因子:4.9
- 作者:DeLacey, Patricia M.;Sen, Sharmi;Snyder-Mackler, Noah
- 通讯作者:Snyder-Mackler, Noah
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Noah Snyder-Mackler其他文献
Socioecological drivers of injuries and aggression in female and male rhesus macaques (Macaca mulatta)
- DOI:
10.1007/s00265-025-03587-3 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:1.900
- 作者:
Melissa A. Pavez-Fox;Erin R. Siracusa;Samuel Ellis;Clare M. Kimock;Nahiri Rivera-Barreto;Josue E. Negron-Del Valle;Daniel Phillips;Angelina Ruiz-Lambides;Noah Snyder-Mackler;James P. Higham;Delphine De Moor;Lauren J. N. Brent - 通讯作者:
Lauren J. N. Brent
SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection
恒河猴在早期全身感染期间,SIV 感染会导致其前额叶皮质中基因表达的改变和中间神经元的丧失。
- DOI:
10.1038/s41398-025-03261-2 - 发表时间:
2025-01-31 - 期刊:
- 影响因子:6.200
- 作者:
Richard C. Crist;Samar N. Chehimi;Saurabh S. Divakaran;Michael J. Montague;Sébastien Tremblay;Noah Snyder-Mackler;Martin O. Bohlen;Kenneth L. Chiou;Trish M. Zintel;Michael L. Platt;Halvor Juul;Guido Silvestri;Matthew R. Hayes;Dennis L. Kolson;Benjamin C. Reiner - 通讯作者:
Benjamin C. Reiner
Associations between social behaviour and proinflammatory immune activation are modulated by age in a free-ranging primate population
在一个自由放养的灵长类动物群体中,社会行为和促炎免疫激活之间的关联受年龄的调节。
- DOI:
10.1016/j.anbehav.2024.10.035 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:2.100
- 作者:
Eve B. Cooper;Connor Whalen;Nina Beeby;Josué E. Negron-Del Valle;Daniel Phillips;Cayo Biobank Research Unit;Noah Snyder-Mackler;Lauren J.N. Brent;James P. Higham - 通讯作者:
James P. Higham
Acoustic variation and group level convergence of gelada, emTheropithecus gelada/em, contact calls
狮尾狒(学名:Theropithecus gelada)接触叫声的声学变异与群体层面的趋同
- DOI:
10.1016/j.anbehav.2023.10.002 - 发表时间:
2024-01-01 - 期刊:
- 影响因子:2.100
- 作者:
Melissa C. Painter;Morgan L. Gustison;Noah Snyder-Mackler;Elizabeth Tinsley Johnson;Aliza le Roux;Thore J. Bergman - 通讯作者:
Thore J. Bergman
Noah Snyder-Mackler的其他文献
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{{ truncateString('Noah Snyder-Mackler', 18)}}的其他基金
Collaborative Research: An integrative approach to understanding variation in patterns of aging in primates
合作研究:了解灵长类动物衰老模式变化的综合方法
- 批准号:
2235565 - 财政年份:2023
- 资助金额:
$ 6.32万 - 项目类别:
Standard Grant
Functional genomics of high-altitude adaptation in a non-human primate model
非人类灵长类动物模型高海拔适应的功能基因组学
- 批准号:
2010309 - 财政年份:2020
- 资助金额:
$ 6.32万 - 项目类别:
Standard Grant
Functional genomics of high-altitude adaptation in a non-human primate model
非人类灵长类动物模型高海拔适应的功能基因组学
- 批准号:
1848900 - 财政年份:2019
- 资助金额:
$ 6.32万 - 项目类别:
Standard Grant
Collaborative research: Physiological signatures of variable weaning strategies in wild primates
合作研究:野生灵长类动物不同断奶策略的生理特征
- 批准号:
1723237 - 财政年份:2017
- 资助金额:
$ 6.32万 - 项目类别:
Continuing Grant
Genetic and Behavioral Predictors of Susceptibility to Social Stress
社会压力易感性的遗传和行为预测因素
- 批准号:
1306134 - 财政年份:2013
- 资助金额:
$ 6.32万 - 项目类别:
Continuing Grant
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