The developmental origins of social interaction processing in the human brain

人脑社交互动处理的发育起源

• 批准号: 2017229
• 负责人: Tobias Grossmann
• 金额: $ 57.48万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2017229&HistoricalAwards=false
• 关键词: developmental; origins; social; interaction; processing

Humans are intensely social beings who live in complex groups. One major challenge for the human brain is to enable us to effectively navigate and benefit from this complex social environment. This project will examine the early development of the brain systems that enable us to process and learn from third-person social interactions. The researchers will investigate brain, cognitive and behavioral development during infancy with a specific focus on observing social interactions. By revealing how brain processes underpinning early infant social and cognitive development unfold, this research will fill an important gap in our knowledge and has broad implications for understanding healthy and atypical development. The project is multidisciplinary in nature as it uses a cutting-edge approach combining neuroscience, behavioral and experience-sampling methods. The findings will be broadly applicable to multiple disciplines and will inform the brain, cognitive and social sciences. The planned experiments will provide valuable research opportunities and unique training for students. The project has implications for early education, intervention and may help guide public policy decisions concerning infant and child development.The current project tests the hypothesis that brain systems in prefrontal and temporal cortex begin to specialize in third-person social interaction processing during infancy. To this end, this project will (i) examine developmental changes in the neural processing of social interactions during infancy using a multi-method neuroimaging approach, (ii) assess the characteristics and functions of this brain system, (iii) investigate variability and the role of experience in the emergence of this brain system in a longitudinal study. Uncovering the neurodevelopmental roots of social interaction processing in infancy will have a wide-ranging impact as it informs our understanding of human nature and cognition in profound ways and has the potential to inspire further research into social intelligence in man and machines. Through this project and its findings it will be possible to foster a better understanding among the public of how important early social development occurs and what role brain development and experience plays.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人类是高度社会化的生物，生活在复杂的群体中。人类大脑面临的一个主要挑战是使我们能够有效地导航并从这个复杂的社会环境中受益。该项目将研究大脑系统的早期发展，使我们能够处理和学习第三人称社交互动。研究人员将调查婴儿期的大脑、认知和行为发展，特别关注观察社会互动。通过揭示支撑早期婴儿社会和认知发展的大脑过程，这项研究将填补我们知识中的一个重要空白，并对理解健康和非典型发展具有广泛的意义。该项目本质上是多学科的，因为它使用了结合神经科学，行为和经验采样方法的尖端方法。这些发现将广泛适用于多个学科，并将为大脑，认知和社会科学提供信息。计划中的实验将为学生提供宝贵的研究机会和独特的培训。该项目具有早期教育，干预的影响，并可能有助于指导公共政策的决定，有关婴幼儿development.The当前的项目测试的假设，即大脑系统的前额叶和颞叶皮层开始专门处理第三人称社会互动在婴儿期。为此，该项目将（i）使用多方法神经成像方法检查婴儿期社交互动神经处理的发育变化，（ii）评估该大脑系统的特征和功能，（iii）调查变化性和作用在纵向研究中，经验在该大脑系统的出现中发挥作用。揭示婴儿期社会互动处理的神经发育根源将产生广泛的影响，因为它以深刻的方式告知我们对人性和认知的理解，并有可能激发对人类和机器社会智能的进一步研究。通过该项目及其研究成果，将有可能促进公众更好地理解早期社会发展的重要性以及大脑发育和经验发挥的作用。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Processing third-party social interactions in the human infant brain

处理人类婴儿大脑中的第三方社交互动

• DOI: 10.1016/j.infbeh.2022.101727
• 发表时间: 2022
• 期刊: Infant Behavior and Development
• 影响因子: 2.1
• 作者: Farris, Katrina;Kelsey, Caroline M.;Krol, Kathleen M.;Thiele, Maleen;Hepach, Robert;Haun, Daniel B.;Grossmann, Tobias
• 通讯作者: Grossmann, Tobias

Gut microbiota composition is associated with newborn functional brain connectivity and behavioral temperament

• DOI: 10.1016/j.bbi.2020.11.003
• 发表时间: 2021-01-01
• 期刊: BRAIN BEHAVIOR AND IMMUNITY
• 影响因子: 15.1
• 作者: Kelsey, Caroline M.;Prescott, Stephanie;Grossmann, Tobias
• 通讯作者: Grossmann, Tobias