MRI TRACK I: Acquisition of a Super Resolution Module for Biological and Advanced Materials Imaging

MRI TRACK I:获取用于生物和先进材料成像的超分辨率模块

基本信息

  • 批准号:
    2019023
  • 负责人:
  • 金额:
    $ 31.14万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-01 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

Light-based microscopes are indispensable to the advancement of many scientific fields. Lamentably, there is a lower limit to the size of objects that can be observed due to physics of light itself. This barrier impedes investigation of minuscule objects. Fortunately, recent advances have helped overcome this hurdle, yielding “super-resolution” microscopes. The specific super-resolution technology acquired by this award is well-suited for imaging dynamic objects like those in cells as well as nanoparticles created in the laboratory. Projects that will take advantage of the microscope include: material scientists studying assembly of high performance plastic-like materials, cell biologists and biochemists investigating cell components important in Alzheimer’s and genetic tools, and microbiologists that examine bacterial community structures involved in infection and plant-soil interactions. Availability of the super-resolution microscope will provide opportunities for training in cutting-edge imaging for faculty and students throughout Mississippi. Emphasis will be placed on involving underserved communities and faculty at small colleges and universities This proposal requests a Leica Stimulated Emission Depletion 3X super resolution microscopy component. The system enables imaging of nano-scale objects smaller than the diffraction limit of light without the need for specialized fluorophores, intense laser exposure, and heavy computational processing of data. Thus, acquisition of the component will benefit numerous projects at the host institute as well as other academic research in the region. It will integrate with an existing confocal microscope housed and maintained in an imaging core facility on the University of Southern Mississippi Hattiesburg campus. The core is a multi-user facility that provides access, consultation, training, and technical support free of charge to Mississippi academic scientists. The module will support the research and education missions of the core facility along with projects supported by multi-institute consortia aimed at engineering novel spectral properties in organic compounds. Together this makes the system a highly accessible instrument, offering a cutting-edge imaging mode to even the most resource limited researchers, while synergistically empowering statewide programs to advance their research programs and education missions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
光学显微镜对于许多科学领域的进步是不可或缺的。可悲的是,由于光本身的物理性质,可以观察到的物体的大小有一个下限。这一障碍阻碍了对微小物体的研究。幸运的是,最近的进展有助于克服这一障碍,产生了“超分辨率”显微镜。该奖项获得的特定超分辨率技术非常适合对细胞中的动态对象以及实验室中创建的纳米颗粒进行成像。 利用显微镜的项目包括:研究高性能塑料类材料组装的材料科学家,研究阿尔茨海默氏症和遗传工具中重要细胞成分的细胞生物学家和生物化学家,以及研究感染和植物-土壤相互作用中涉及的细菌群落结构的微生物学家。超分辨率显微镜的可用性将为整个密西西比的教师和学生提供尖端成像培训的机会。重点将放在涉及服务不足的社区和教师在小型学院和大学。该提案要求徕卡受激发射损耗3X超分辨率显微镜组件。该系统能够对小于光衍射极限的纳米级物体进行成像,而无需专门的荧光团,强烈的激光曝光和繁重的数据计算处理。因此,获得该组件将有利于东道机构的许多项目以及该地区的其他学术研究。它将与现有的共聚焦显微镜集成,并在南密西西比哈蒂斯堡大学校园的成像核心设施中进行维护。核心是一个多用户设施,免费为密西西比的学术科学家提供访问、咨询、培训和技术支持。该模块将支持核心设施的研究和教育任务,沿着由多个研究所财团支持的项目,旨在设计有机化合物的新光谱特性。这使得该系统成为一个高度可访问的仪器,即使是资源最有限的研究人员也能提供尖端的成像模式,同时协同授权全州范围的项目来推进他们的研究项目和教育任务。该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Alex Flynt其他文献

Alex Flynt的其他文献

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{{ truncateString('Alex Flynt', 18)}}的其他基金

CAREER: The Small RNA Biology of Lophotrochozoa
职业生涯: 轮轮动物的小 RNA 生物学
  • 批准号:
    1845978
  • 财政年份:
    2019
  • 资助金额:
    $ 31.14万
  • 项目类别:
    Continuing Grant
Metabolism of plant derived small RNAs in Spider Mites
叶螨中植物源性小 RNA 的代谢
  • 批准号:
    1616725
  • 财政年份:
    2016
  • 资助金额:
    $ 31.14万
  • 项目类别:
    Continuing Grant

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