I-Corps: Laparoscopic Induction Heaters for Biomedical Applications

I-Corps：用于生物医学应用的腹腔镜感应加热器

• 批准号: 2019736
• 负责人: Eduardo Juan
• 金额: $ 5万
• 依托单位: University of Puerto Rico Mayaguez
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2019736&HistoricalAwards=false
• 关键词: Corps; Laparoscopic; Induction; Heaters; Biomedical

The broader impact/commercial potential of this I-Corps project is the development of miniature induction heaters to heat electrically conductive materials in hard-to-reach places within the human body. The goal is to develop smaller, more focused magnetic field applicators that may be used in patients having metallic implants (e.g., hip replacement implants, stents, etc.) otherwise ineligible to receive current magnetic nanoparticle-based cancer therapies. Additionally, the aim is to enable the development of new medical procedures requiring in situ, non-contact heating of electrically conductive materials in relatively inaccessible places within the human body. This I-Corps project is to explore translation of miniature induction-heating devices for biomedical applications, such as in laparoscopic procedures with the intention of treating intra-peritoneal metastatic cancer such as ovarian cancer using magnetic fluid hyperthermia (MFH). Capabilities include generating an alternating magnetic field of up to 18 kA/m at a frequency of 290kHz. With this field intensity, it is possible to heat a stainless-steel disk to more than 500°C and a suspension of iron oxide magnetic nanoparticles to maximum temperatures ranging from 39°C to 96°C, depending on particle concentration. Translational research includes: a) development of novel magnetic field generators allowing a more localized MFH prostate cancer therapy, b) further exploration of the concept of having miniature induction heaters to heat electrically conductive materials in hard-to-reach places within the human body, c) determining the capabilities of the technology in heating magnetic nanoparticles to kill cancer cells in vitro and d) determining the devices' capabilities in heating magnetic nanoparticles to ablate porcine tissues and estimate severity and extent of tissue damage under different operating conditions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目更广泛的影响/商业潜力是开发微型感应加热器，以加热人体内难以到达的地方的导电材料。 目标是开发更小、更集中的磁场施加器，其可用于具有金属植入物的患者（例如，髋关节置换植入物、支架等）否则不适合接受目前基于磁性纳米颗粒的癌症治疗。 此外，目的是能够开发需要在人体内相对难以接近的地方对导电材料进行原位非接触式加热的新医疗程序。 该I-Corps项目旨在探索微型感应加热设备在生物医学应用中的应用，例如在腹腔镜手术中，旨在使用磁流体热疗（MFH）治疗腹膜内转移癌，如卵巢癌。 能力包括在290 kHz的频率下产生高达18 kA/m的交变磁场。 在这种场强下，可以将不锈钢盘加热到500°C以上，将氧化铁磁性纳米颗粒的悬浮液加热到39°C至96°C的最高温度，这取决于颗粒浓度。 翻译研究包括：a）开发允许更局部化的MFH前列腺癌治疗的新型磁场发生器，B）进一步探索具有微型感应加热器以加热人体内难以到达的位置中的导电材料的概念，c）确定该技术在体外加热磁性纳米颗粒以杀死癌细胞的能力，以及该奖项反映了NSF的法定使命，并通过使用基金会的知识产权进行评估，被认为值得支持。优点和更广泛的影响审查标准。